Aptide scaffold protein anti-Human Fibronectin extra domain B (EDB)
CAT#: SAP-L047
The aptide that bound Fibronectin extra domain B (EDB) was isolated from the library using Phage display techonology. After affinity maturation, aptide variants were identified having affinities for Fibronectin extra domain B (EDB) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg
Normal Tissue
Figure 5 Placenta
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1
❮
❯
Specifications
- Scaffold Name
- Aptide
- Origin
- Aptide
- Target
- Fibronectin extra domain B (EDB)
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
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Targeted EDB Detection
This aptide scaffold is highly specific for the Fibronectin extra domain B (EDB). It has been a critical reagent in our microscopy studies, helping us visualize splice variants associated with wound healing and metastasis.
Verified By Western Blot
We validated the binding of this scaffold protein using Western Blotting. It produced clear bands corresponding to the target isoforms, confirming the efficacy of the affinity maturation process utilized during its development.
Q&As
-
What specific domain of Fibronectin does this aptide bind?
A: This aptide binds specifically to the Fibronectin extra domain B (EDB). EDB is a domain subject to alternative splicing and is involved in cell adhesion and migration processes, including metastasis and wound healing.
-
What technology was used to identify this binder?
A: The aptide that binds Fibronectin extra domain B (EDB) was isolated from the library using Phage display technology. Subsequent affinity maturation identified variants with suitable affinities as determined by biosensor technology.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
MSDS
COA
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