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FN1

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This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

Targets:
FN1 & HSG
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Scaffold Name:
Kunitz domains
Target:
Fibronectin (α5β1)
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
Ubiquitin
Target:
FN1
Species Reactivity:
Human
Derivation:
Phage display
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
scIL12
Host:
Humanized from Mouse
Cytokine 1 Species:
Human
Molecule Class:
IgG3-scIL12
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL4
Host:
Human
Cytokine 1 Species:
Mouse
Molecule Class:
scFv-IL4
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
VEGF
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-VEGF
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
GM-CSF
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-GM-CSF
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IFNγ
Host:
Human
Cytokine 1 Species:
Mouse
Molecule Class:
scFv-IFNγ
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL10
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-IL10
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Humanized from Mouse
Cytokine 1 Species:
Mouse
Molecule Class:
IgG1-IL12
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Humanized from Mouse
Cytokine 1 Species:
Human
Molecule Class:
IgG1-IL12
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-CH4-IL12
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
IL12-scFv
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL15
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-IL15
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scIL12-scFv-CH4
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
GM-CSF
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
GM-CSF-scFv-scFv-GM-CSF
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-IL12-scFv
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL2
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
scFv-IL2
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL2
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
IL2-scFv
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
GM-CSF
Host:
Human
Cytokine 1 Species:
Mouse
Molecule Class:
GM-CSF-scFv
Target:
EDB
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Mouse
Molecule Class:
p40-scFv-scFv-p35
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