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    Recombinant Anti-FN1 Eliminating Antibody, pH-Sensitive (VS-0625-YC121)

    CAT#: VS-0625-YC121

    The anti-FN1 eliminating antibody is an engineered pH-sensitive antibody against human FN1. FN1 binds integrins and other matrix components, crucial for cellular interactions. The antibody has a novel FN1-sweeping activity in vivo, which selectively eliminatesthe soluble FN1 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.

    Gene Expression
    ❮
    Figure 1 Cerebral cortex Figure 2 Colon Figure 3 Liver Figure 4 Testis Figure 5 Placenta Figure 6 Lymph node Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
    ❯

    Specifications

    • Immunogen
    • A region in the ED-A domain of human cellular fibronectin.
    • Host Species
    • Human
    • Type
    • Human IgG1 kappa
    • Specificity
    • Human FN1
    • Species Reactivity
    • Human
    • Applications
    • Antigen-Sweeping In Vivo.

    Product Property

    • Purification
    • Protein A/G purified
    • Purity
    • >95%
    • Format
    • Liquid
    • Buffer
    • PBS only
    • Preservative
    • None
    • Storage
    • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • FN1; fibronectin 1; fibronectin; CIG; cold insoluble globulin; FINC; GFND2; LETS; migration stimulating factor; MSF; cold-insoluble globulin; migration-stimulating factor; FN; FNZ; ED-B; GFND; DKFZp686H0342; DKFZp686I1370; DKFZp6
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    Related Diseases

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    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0625-YC121.pdf

    MSDS

    MSDS - VS-0625-YC121.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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