Anti-Human RGMA Recombinant Antibody (TAB-421CQ)
CAT#: TAB-421CQ
Recombinant monoclonal antibody to RGMA. This antibody is a human monoclonal antibody that can neutralize repulsive guidance molecule A (RGMa), a protein that inhibits neural regeneration and contributes to inflammation and damage in neurological disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39880/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44222/1038_D3_2_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32697_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12343/32439_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AF22, BEWO, MOLT-4, NTERA-2, REH)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182175-RGMA
❮
❯
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1, λ1
- Specificity
- Human RGMA
- Species Reactivity
- Human
- Applications
- Used for immunoassay techniques such as: Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Immunofluorescence; Immunoprecipitation; Flow Cytometry; Functional Studies
- Conjugate
- Unconjugated
- Related Disease
- Multiple Sclerosis
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAB-421CQ. Click the button above to contact us or submit your feedback about this product.
Versatility in Research Applications
The ability to use this recombinant antibody across several platforms like ELISA and IHC enhances its utility in neurobiological research. The reliability and consistency in results have significantly advanced our understanding of RGMA-related mechanisms.
Instrumental for Multiple Assays
We've used this antibody in multiple assays, including immunoprecipitation and immunofluorescence, with excellent results. Its performance has been instrumental in driving forward our research in neuroinflammatory pathways.
Q&As
-
What applications can benefit from this antibody?
A: The antibody supports a wide array of applications such as ELISA, IHC, IF, IP, and FC, making it multifaceted for analyzing RGMA's role in neuroinflammation and regeneration.
-
What is the significance of the antibody's unconjugated format?
A: The unconjugated format provides versatility for researchers to select their preferred binding and detection systems in various experimental setups.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-421CQ, RRID: AB_3111933)
Copy citation
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
TGF-β Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "RGMA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3059 | Hi-Affi™ Recombinant Rabbit Anti-RGMA Monoclonal Antibody (DS3059AB) | WB, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-070CN | Human Anti-RGMA Recombinant Antibody (NS-070CN) | ELISA, Neut, FuncS | Human IgG |
| NS-071CN | Human Anti-RGMA Recombinant Antibody (NS-071CN) | ELISA | Human IgG |
| NS-072CN | Human Anti-RGMA Recombinant Antibody (NS-072CN) | ELISA | Human IgG |
| NS-073CN | Human Anti-RGMA Recombinant Antibody (NS-073CN) | FC, ELISA | Human IgG |
| NS-074CN | Human Anti-RGMA Recombinant Antibody (NS-074CN) | FC, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0635-CN | Rat Anti-RGMA Recombinant Antibody (HPAB-0635-CN) | ELISA, FC, IF | Rat IgG |
| HPAB-0636-CN | Rat Anti-RGMA Recombinant Antibody (HPAB-0636-CN) | ELISA | Rat IgG |
| HPAB-0637-CN | Human Anti-RGMA Recombinant Antibody (HPAB-0637-CN) | ELISA, FC, IF | Chimeric (rat/human) IgG1 |
| HPAB-0638-CN | Human Anti-RGMA Recombinant Antibody (HPAB-0638-CN) | ELISA, FC, IF | Humanized IgG |
| HPAB-0617YY | Human Anti-RGMA Recombinant Antibody (HPAB-0617YY) | ELISA, FuncS | Humanized IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0635-CN-S(P) | Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0635-CN-S(P)) | ELISA, FC, IF | Rat scFv |
| HPAB-0636-CN-S(P) | Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0636-CN-S(P)) | ELISA | Rat scFv |
| HPAB-0637-CN-S(P) | Mouse Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0637-CN-S(P)) | ELISA, FC, IF | Mouse scFv |
| HPAB-0638-CN-S(P) | Human Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0638-CN-S(P)) | ELISA, FC, IF | Humanized scFv |
| HPAB-0617YY-S(P) | Human Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0617YY-S(P)) | ELISA, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0635-CN-F(E) | Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0635-CN-F(E)) | ELISA, FC, IF | Rat Fab |
| HPAB-0636-CN-F(E) | Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0636-CN-F(E)) | ELISA | Rat Fab |
| HPAB-0637-CN-F(E) | Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0637-CN-F(E)) | ELISA, FC, IF | Chimeric (rat/human) Fab |
| HPAB-0638-CN-F(E) | Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0638-CN-F(E)) | ELISA, FC, IF | Humanized Fab |
| HPAB-0617YY-F(E) | Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0617YY-F(E)) | ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-421CQ | Afuco™ Anti-RGMA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-421CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY173 | Human Anti-RGMA scFv-Fc Chimera (VS-0425-FY173) | ELISA, Inhib | Human IgG1, scFv-Fc |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
-2-1.png)
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, IHC, FC, IP, IF, FuncS
-3.jpg)
Application: Neut
Application: WB, FC, IF, Inhib, ELISA, IHC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
