PE-DR1/Human CEACAM5 (DTGFYTLHVIKSDLV) MHC Tetramer

Name: PE-DR1/Human CEACAM5 (DTGFYTLHVIKSDLV) MHC Tetramer
SKU: MHC-LC2020
Rating: 5 (1 reviews)

CAT#: MHC-LC2020

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CEACAM5 of peptide DTGFYTLHVIKSDLV covering 116-130 and DR1 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg

Normal Tissue Figure 3 Colon

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg

Normal Tissue Figure 4 Rectum

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5

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Specifications

Allele
DR1

Class
Class II

MHC Species
Human

Antigen
CEACAM5

Antigen Species
Human

Peptide
DTGFYTLHVIKSDLV

Range
116-130

Conjugate
PE

Application
FCM

Target

Antigen Introduction
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

Alternative Names
CEACAM5; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e

Gene ID
1048

UniProt ID
P06731

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Datasheet

Datasheet - MHC-LC2020.pdf

MSDS

MSDS - MHC-LC2020.pdf

COA

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