Recombinant Anti-Human IL17A Antibody (Fc glycosylation)
CAT#: Gly-077LC
This product is a humanized monoclonal antibody with N-glycosylation site in the Fc region. The antibody with enhanced ADCC specifically binds IL-17A and can be potentially used in the treatment of autoimmune disease.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
Normal Tissue
Figure 7 Tonsil
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
❮
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Glyco-engineering
- Glycosylation site
- Asn296 in Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Enhanced ADCC
Specifications
- Target
- IL-17A (Interleukin 17A)
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- Ixekizumab
- Applications
- ELISA
Target
- Alternative Names
- IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- Related Disease
- Autoimmune disease
- Gene ID
- 3605
- UniProt ID
- Q16552
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0863-CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0863-CN-S(P)) | ELISA, Neut | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-176 | Human Anti-IL17A Recombinant Antibody (PABW-176) | Neut, ELISA, WB | Human IgG |
| MOB-1196MZ | Recombinant Mouse Anti-Human IL17A Antibody (clone 2I7) | WB | Mouse antibody |
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| HPAB-0208-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0208-LSX) | ELISA, FuncS | Human IgG |
| HPAB-0209-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0209-LSX) | ELISA | Chimeric IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030ZJ | Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ) | ELISA, Neut | Mouse IgG |
| TAB-030ZJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P)) | ELISA, Neut | Mouse scFv |
| TAB-030ZJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-078ZJ | Human Anti-IL17A Recombinant Antibody (TAB-078ZJ) | ELISA, Block, Neut | Human antibody |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| NEUT-1202CQ | Mouse Anti-IL17A Recombinant Antibody (NEUT-1202CQ) | Neut | Mouse IgG2a |
| NEUT-1203CQ | Mouse Anti-IL17A Recombinant Antibody (NEUT-1203CQ) | Neut | Mouse IgG1 |
| NEUT-1204CQ | Mouse Anti-IL17A Recombinant Antibody (clone 403D10.01) | Neut, FC | Mouse IgG1 |
| NEUT-1205CQ | Mouse Anti-IL17A Recombinant Antibody (clone 408H6.01) | Neut, ELISA, FC | Mouse IgG2a |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-042CN | Mouse Anti-IL17A Recombinant Antibody (NS-042CN) | ELISA, FC | Mouse IgG |
| NS-042CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E)) | ELISA, FC | Mouse Fab |
| NS-042CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0148-FY-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0148-FY-F(E)) | AG | Humanized Fab |
| HPAB-0240CQ-F(E) | Human Anti-IL17A Recombinant Antibody (clone h142); Fab Fragment | ELISA, Block | Human Fab |
| HPAB-0162-YJ-F(E) | Human Anti-IL17A Recombinant Antibody (clone CBI04YJ); Fab Fragment | ELISA, FuncS | Humanized Fab |
| HPAB-0459-YJ-F(E) | Human Anti-IL17A Recombinant Antibody (clone A13M); Fab Fragment | ELISA, FC, Neut, FuncS | Human Fab |
| HPAB-0460-YJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0460-YJ-F(E)) | ELISA, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| AFC-TAB-H08 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-H57 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H57) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY3490 | Anti-Human IL17A Immunohistochemistry Kit | IHC | |
| VS-0525-XY3491 | Anti-Mouse IL17A Immunohistochemistry Kit | IHC |
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