Human Anti-IL17A (clone Antibody 7) scFv-Fc Chimera
CAT#: VS-0325-FY96
The anti-IL17A scFv-Fc antibody targets IL17A, a cytokine involved in inflammation and immune responses. It has therapeutic potential in treating autoimmune diseases and inflammatory conditions, such as psoriasis and rheumatoid arthritis. The scFv-Fc format enhances its stability and bioavailability, improving its effectiveness in modulating IL17A signaling.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
Normal Tissue
Figure 7 Tonsil
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Antibody 7 is highly specific for human IL-17A and exhibits minimal cross-reactivity with other IL-17 family members (IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F).
- Species Reactivity
- Human
- Clone
- Antibody 7
- Applications
- ELISA, Inhibition
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 17A
- Gene ID
- 3605
- UniProt ID
- Q16552
- Long Name
- Interleukin 17A
- Sequence Similarities
- Belongs to the IL-17 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N-glycosylated. Found both in glycosylated and nonglycosylated forms.
- Protein Refseq
- NP_002181.1
- Function
- Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361).
Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:19825828, PubMed:21350122, PubMed:17911633, PubMed:18684971, PubMed:8676080, PubMed:24120361).
Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity).
In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0325-FY96. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone Antibody 7"
- CAT
- Product Name
See other products for "IL17A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1390z | Mouse Anti-IL17A Recombinant Antibody (clone 22B9) | FuncS | Mouse IgG2b |
| PABL-237 | Human Anti-IL17A Recombinant Antibody (clone CNTO7357) | WB, IHC, FuncS | Human IgG |
| PABL-238 | Human Anti-IL17A Recombinant Antibody (clone Fab6785) | WB, ELISA, FuncS | Human IgG |
| HPAB-0207-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0207-LSX) | ELISA | Human IgG |
| HPAB-0208-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0208-LSX) | ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-069 | Anti-Human IL17A Recombinant Antibody (TAB-069) | IF, IHC, ELISA, FC | IgG1 - kappa |
| TAB-078ZJ | Human Anti-IL17A Recombinant Antibody (TAB-078ZJ) | ELISA, Block, Neut | Human antibody |
| TAB-079ZJ | Human Anti-IL17A Recombinant Antibody (TAB-079ZJ) | ELISA, Block, Neut | Human IgG1 |
| TAB-080ZJ | Human Anti-IL17A Recombinant Antibody (TAB-080ZJ) | ELISA, Block, Neut | Human antibody |
| PABX-116 | Recombinant Human Anti-Il-17A Antibody (CAT-2200) | WB, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H57 | Anti-Human IL17A Recombinant Antibody (Perakizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| TAB-H08 | Anti-Human IL17A/IL17F Recombinant Antibody (TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
| TAB-048ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) | ELISA, Neut | Human scFv |
| TAB-048ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-048ZJ-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-399CL | Human Anti-IL17A Recombinant Antibody (TAB-399CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030ZJ | Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ) | ELISA, Neut | Mouse IgG |
| TAB-030ZJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P)) | ELISA, Neut | Mouse scFv |
| TAB-030ZJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-077LC | Recombinant Anti-Human IL17A Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0289MZ | Chicken Anti-Interleukin-17a Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1202CQ | Mouse Anti-IL17A Recombinant Antibody (NEUT-1202CQ) | Neut | Mouse IgG2a |
| NEUT-1203CQ | Mouse Anti-IL17A Recombinant Antibody (NEUT-1203CQ) | Neut | Mouse IgG1 |
| NEUT-1204CQ | Mouse Anti-IL17A Recombinant Antibody (clone 403D10.01) | Neut, FC | Mouse IgG1 |
| NEUT-1205CQ | Mouse Anti-IL17A Recombinant Antibody (clone 408H6.01) | Neut, ELISA, FC | Mouse IgG2a |
| NEUT-1206CQ | Mouse Anti-IL17A Recombinant Antibody (clone 409H7.05) | Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0207-LSX-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0207-LSX-S(P)) | ELISA | Mouse scFv |
| HPAB-0208-LSX-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0208-LSX-S(P)) | ELISA | Mouse scFv |
| HPAB-0210-LSX-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0210-LSX-S(P)) | ELISA | Humanized scFv |
| HPAB-0211-LSX-S(P) | Rat Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0211-LSX-S(P)) | ELISA | Rat scFv |
| HPAB-0212-LSX-S(P) | Rat Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0212-LSX-S(P)) | ELISA | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-042CN | Mouse Anti-IL17A Recombinant Antibody (NS-042CN) | ELISA, FC | Mouse IgG |
| NS-042CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E)) | ELISA, FC | Mouse Fab |
| NS-042CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0862-CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0862-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0863-CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0863-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0864-CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0864-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0865-CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0865-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0459-YJ-F(E) | Human Anti-IL17A Recombinant Antibody (clone A13M); Fab Fragment | ELISA, FC, Neut, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-458CQ | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-458CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-069 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-069) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H08 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-H57 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H57) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY147 | AbPlus™ Anti-IL17A Magnetic Beads (41809) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY130 | CytoStream™ Mouse Anti-IL17A Recombinant Antibody (VS-0225-XY130) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3489 | Anti-IL17A Immunohistochemistry Kit | IHC | |
| VS-0525-XY3490 | Anti-Human IL17A Immunohistochemistry Kit | IHC | |
| VS-0525-XY3491 | Anti-Mouse IL17A Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, ELISA, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FuncS
Application: ELISA, WB, Microarray, Block
Application: ELISA, FC, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
