Anti-Human IL17A Recombinant Antibody (Perakizumab) (CAT#: TAB-H57)
Recombinant Humanized (from mouse) antibody to Human IL17A. Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis. It binds to IL17A and acts as an immunomodulator.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
Figure 7 Tonsil
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
Specifications
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- IL17A (interleukin 17A, IL-17A) [Homo sapiens]
- Species Reactivity
- Human
- Applications
- Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.
- CAS
- 89957-37-9
- Generic Name
- perakizumab
- MW
- 145.4 kDa
- Related Disease
- Rheumatoid arthritis (RA)
Product Property
- Purity
- >95.0% as determined by analysis by RP-HPLC.
Target
- Alternative Names
- perakizumab;89957-37-9;RG4934;RO5310074;huMAb IL-17;3C1;IL17A;interleukin 17A;CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);interleukin-17A;cytotoxic T lymphocyte associated protein 8;IL 17;IL 17A;CTLA-8;cytotoxic T-lym
- Gene ID
- 3605
- UniProt ID
- Q16552
Related Resources
Please refer to Perakizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Perakizumab.
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Perakizumab"
Afuco™ Anti-IL17A ADCC Recombinant Antibody (Perakizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human IL17A. Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis. It binds to IL17A and acts as an immunomodulator.
See other products for "IL17A"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H08 | Anti-Human IL17A Recombinant Antibody (Bimekizumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
| TAB-048ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) | ELISA, Neut | Human scFv |
| TAB-048ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-048ZJ-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-458CQ | Anti-Human IL17A Recombinant Antibody (Vunakizumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-399CL | Human Anti-IL17A Recombinant Antibody (TAB-399CL) | ELISA | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-237 | Human Anti-IL17A Recombinant Antibody (clone CNTO7357); Fab Fragment | WB, IHC, FuncS | Human Fab |
| PFBL-238 | Human Anti-IL17A Recombinant Antibody (clone Fab6785); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0207-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0207-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0208-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0208-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0209-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0209-LSX-F(E)) | ELISA | Chimeric Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030ZJ | Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ) | ELISA, Neut | Mouse IgG |
| TAB-030ZJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P)) | ELISA, Neut | Mouse scFv |
| TAB-030ZJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E)) | ELISA, Neut | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-078ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-078ZJ-S(P)) | ELISA, Block, Neut | Human scFv |
| TAB-078ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-078ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
| TAB-079ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-079ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
| TAB-080ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-080ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
| PABX-116-F (E) | Recombinant Human Anti-Il-17A Antibody Fab Fragment (CAT-2200) | WB, ELISA, FuncS | Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-077LC | Recombinant Anti-Human IL17A Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0289MZ | Chicken Anti-Interleukin-17a Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1202CQ | Mouse Anti-IL17A Recombinant Antibody (clone 665909) | Neut | Mouse IgG2a |
| NEUT-1203CQ | Mouse Anti-IL17A Recombinant Antibody (clone M273) | Neut | Mouse IgG1 |
| NEUT-1204CQ | Mouse Anti-IL17A Recombinant Antibody (clone 403D10.01) | Neut, FC | Mouse IgG1 |
| NEUT-1205CQ | Mouse Anti-IL17A Recombinant Antibody (clone 408H6.01) | Neut, ELISA, FC | Mouse IgG2a |
| NEUT-1206CQ | Mouse Anti-IL17A Recombinant Antibody (clone 409H7.05) | Neut, FC | Mouse IgG1 |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-042CN | Mouse Anti-IL17A Recombinant Antibody (NS-042CN) | ELISA, FC | Mouse IgG |
| NS-042CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E)) | ELISA, FC | Mouse Fab |
| NS-042CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P)) | ELISA, FC | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0148-FY | Human Anti-IL17A Recombinant Antibody (HPAB-0148-FY) | AG | Humanized IgG |
| HPAB-0862-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0862-CN) | WB, ELISA, IP | Mouse IgG |
| HPAB-0863-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0863-CN) | WB, ELISA | Mouse IgG |
| HPAB-0864-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0864-CN) | WB, ELISA, FC, IHC | Mouse IgG |
| HPAB-0865-CN | Mouse Anti-IL17A Recombinant Antibody (HPAB-0865-CN) | ELISA, Neut | Mouse IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0162-YJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone CBI04YJ); scFv Fragment | ELISA, FuncS | Humanized scFv |
| HPAB-0704-WJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone HC2C1); scFv Fragment | ELISA | Human scFv |
| HPAB-0705-WJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone LC2C1); scFv Fragment | ELISA | Human scFv |
| HPAB-0706-WJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone 2C1LCHC); scFv Fragment | ELISA | Human scFv |
| HPAB-1747-FY-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-1747-FY-F(E)) | WB, ELISA | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-458CQ | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Vunakizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-069 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Secukinumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H08 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Bimekizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-H57 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Perakizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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