Anti-Human IL17A Recombinant Antibody (Perakizumab)

Name: Anti-Human IL17A Recombinant Antibody (Perakizumab)
SKU: TAB-H57
Rating: 5 (1 reviews)

CAT#: TAB-H57

Recombinant Humanized (from mouse) antibody to Human IL17A. Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis. It binds to IL17A and acts as an immunomodulator.

Gene Expression

Normal Tissue Figure 1 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg

Normal Tissue Figure 4 Liver

Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg

Normal Tissue Figure 5 Kidney

Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg

Normal Tissue Figure 7 Tonsil

Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A

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Specifications

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1 - kappa

Specificity
IL17A (interleukin 17A, IL-17A) [Homo sapiens]

Species Reactivity
Human

Applications
Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.

CAS
89957-37-9

Generic Name
perakizumab

MW
145.4 kDa

Related Disease
Rheumatoid arthritis (RA)

Product Property

Purity
>95.0% as determined by analysis by RP-HPLC.

Target

Alternative Names
perakizumab;89957-37-9;RG4934;RO5310074;huMAb IL-17;3C1;IL17A;interleukin 17A;CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);interleukin-17A;cytotoxic T lymphocyte associated protein 8;IL 17;IL 17A;CTLA-8;cytotoxic T-lym

Gene ID
3605

UniProt ID
Q16552

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Biosimilar Overview

Please refer to Perakizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Perakizumab.

Related Diseases

Inflammatory Bowel Diseases

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-H57.pdf

MSDS

MSDS - TAB-H57.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Perakizumab"

Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H57)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human IL17A. It is a humanized monoclonal antibody designed for the treatment of arthritis. It binds to IL17A and acts as an immunomodulator.

See other products for "IL17A"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-069	Anti-Human IL17A Recombinant Antibody (TAB-069)	IF, IHC, ELISA, FC	IgG1 - kappa
TAB-078ZJ-S(P)	Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-078ZJ-S(P))	ELISA, Block, Neut	Human scFv
TAB-079ZJ-S(P)	Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-079ZJ-S(P))	ELISA, Block, Neut	Human scFv
PABX-116	Recombinant Human Anti-Il-17A Antibody (CAT-2200)	WB, ELISA, FuncS	IgG
PABX-116-F (E)	Recombinant Human Anti-Il-17A Antibody Fab Fragment (CAT-2200)	WB, ELISA, FuncS	Fab

CAT	Product Name	Application	Type
TAB-H08	Anti-Human IL17A/IL17F Recombinant Antibody (TAB-H08)	ELISA, FC, IP, FuncS, IF, Neut, WB	IgG1 - kappa
TAB-048ZJ	Human Anti-IL17A Recombinant Antibody (TAB-048ZJ)	ELISA, Neut	Humanized antibody
TAB-048ZJ-S(P)	Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P))	ELISA, Neut	Human scFv
TAB-048ZJ-F(E)	Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-048ZJ-F(E))	ELISA, Neut	Humanized Fab
TAB-458CQ	Anti-Human IL17A Recombinant Antibody (TAB-458CQ)	ELISA, IHC, FC, IP, IF, Inhib	IgG1, κ

CAT	Product Name	Application	Type
TAB-399CL	Human Anti-IL17A Recombinant Antibody (TAB-399CL)	ELISA	Human IgG

CAT	Product Name	Application	Type
TAB-030ZJ	Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ)	ELISA, Neut	Mouse IgG
TAB-030ZJ-S(P)	Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P))	ELISA, Neut	Mouse scFv
TAB-030ZJ-F(E)	Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E))	ELISA, Neut	Mouse Fab

CAT	Product Name	Application	Type
Gly-077LC	Recombinant Anti-Human IL17A Antibody (Fc glycosylation)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
BRD-0289MZ	Chicken Anti-Interleukin-17a Polyclonal IgY	Indirect ELISA, WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-1202CQ	Mouse Anti-IL17A Recombinant Antibody (NEUT-1202CQ)	Neut	Mouse IgG2a
NEUT-1203CQ	Mouse Anti-IL17A Recombinant Antibody (NEUT-1203CQ)	Neut	Mouse IgG1
NEUT-1204CQ	Mouse Anti-IL17A Recombinant Antibody (clone 403D10.01)	Neut, FC	Mouse IgG1
NEUT-1205CQ	Mouse Anti-IL17A Recombinant Antibody (clone 408H6.01)	Neut, ELISA, FC	Mouse IgG2a
NEUT-1206CQ	Mouse Anti-IL17A Recombinant Antibody (clone 409H7.05)	Neut, FC	Mouse IgG1

CAT	Product Name	Application	Type
HPAB-0207-LSX-S(P)	Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0207-LSX-S(P))	ELISA	Mouse scFv
HPAB-0208-LSX-S(P)	Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0208-LSX-S(P))	ELISA	Mouse scFv
HPAB-0210-LSX-S(P)	Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0210-LSX-S(P))	ELISA	Humanized scFv
HPAB-0211-LSX-S(P)	Rat Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0211-LSX-S(P))	ELISA	Rat scFv
HPAB-0212-LSX-S(P)	Rat Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0212-LSX-S(P))	ELISA	Rat scFv

CAT	Product Name	Application	Type
HPAB-0207-LSX-F(E)	Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0207-LSX-F(E))	ELISA	Human Fab
HPAB-0862-CN-F(E)	Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0862-CN-F(E))	ELISA, Neut	Mouse Fab
HPAB-0863-CN-F(E)	Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0863-CN-F(E))	ELISA, Neut	Mouse Fab
HPAB-0864-CN-F(E)	Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0864-CN-F(E))	ELISA, Neut	Mouse Fab
HPAB-0865-CN-F(E)	Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0865-CN-F(E))	ELISA, Neut	Mouse Fab

CAT	Product Name	Application	Type
NS-042CN	Mouse Anti-IL17A Recombinant Antibody (NS-042CN)	ELISA, FC	Mouse IgG
NS-042CN-F(E)	Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E))	ELISA, FC	Mouse Fab
NS-042CN-S(P)	Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P))	ELISA, FC	Mouse scFv

CAT	Product Name	Application	Type
MRO-1964-CN	Rabbit Anti-IL17A Polyclonal Antibody (MRO-1964-CN)	WB, IHC, FC	Rabbit IgG
HPAB-0704-WJ	Human Anti-IL17A Recombinant Antibody (clone HC2C1)	ELISA	Human IgG
HPAB-0705-WJ	Human Anti-IL17A Recombinant Antibody (clone LC2C1)	ELISA	Human IgG
HPAB-0706-WJ	Human Anti-IL17A Recombinant Antibody (clone 2C1LCHC)	ELISA	Human IgG
HPAB-AP683-YC	Mouse Anti-IL17A Recombinant Antibody (HPAB-AP683-YC)	ELISA, Neut	Mouse IgG

CAT	Product Name	Application	Type
AFC-TAB-458CQ	Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-458CQ)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody
AFC-TAB-069	Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-069)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-H08	Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H08)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody
AFC-TAB-H57	Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H57)	ELISA, IP, FC, FuncS, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY147	AbPlus™ Anti-IL17A Magnetic Beads (41809)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0225-XY130	CytoStream™ Mouse Anti-IL17A Recombinant Antibody (VS-0225-XY130)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0325-FY96	Human Anti-IL17A (clone Antibody 7) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application
VS-0525-XY3489	Anti-IL17A Immunohistochemistry Kit	IHC
VS-0525-XY3490	Anti-Human IL17A Immunohistochemistry Kit	IHC
VS-0525-XY3491	Anti-Mouse IL17A Immunohistochemistry Kit	IHC

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