Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-458CQ)

Name: Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-458CQ)
SKU: AFC-TAB-458CQ
Rating: 5 (1 reviews)

CAT#: AFC-TAB-458CQ

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL17A. It is a humanized monoclonal antibody that can be potentially used in the treatment of Autoimmune diseases, Psoriasis.

Gene Expression

Normal Tissue Figure 1 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg

Normal Tissue Figure 4 Liver

Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg

Normal Tissue Figure 5 Kidney

Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg

Normal Tissue Figure 7 Tonsil

Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized

Type
ADCC enhanced antibody

Specificity
Human IL-17A

Species Reactivity
Human

Applications
ELISA, IHC, FC, IP, IF, Inhib

Conjugate
Unconjugated

Generic Name
Vunakizumab

Related Disease
Autoimmune diseases, Psoriasis

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

Gene ID
3605

UniProt ID
Q16552

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Biosimilar Overview

Please refer to Vunakizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Vunakizumab.

Related Diseases

Inflammatory Bowel Diseases

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-458CQ.pdf

MSDS

MSDS - AFC-TAB-458CQ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
HPAB-0207-LSX-F(E)	Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0207-LSX-F(E))	ELISA	Human Fab
HPAB-0208-LSX-F(E)	Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0208-LSX-F(E))	ELISA	Human Fab
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HPAB-1553-FY-S(P)	Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-1553-FY-S(P))	Inhib	Mouse scFv
HPAB-1554-FY-S(P)	Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-1554-FY-S(P))	Inhib	Mouse scFv

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CAT	Product Name	Application	Type
HPAB-0148-FY-S(P)	Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0148-FY-S(P))	AG	Human scFv
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AFC-TAB-H57	Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H57)	ELISA, IP, FC, FuncS, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application
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