A*02:01/Human Mesothelin (VLPLTVAEV) MHC Monomer

Name: A*02:01/Human Mesothelin (VLPLTVAEV) MHC Monomer
SKU: MHC-YF239
Rating: 5 (1 reviews)

CAT#: MHC-YF239

This product is a MHC monomer of biotinylated peptide/MHC complex composed Mesothelin-derived peptide of VLPLTVAEV sequence and A*02:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HeLa

Immunofluorescent staining of human cell line HeLa shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg

Normal Tissue Figure 2 Fallopian tube

Ciliated cells (cilia axoneme)
Staining:

High

Intensity: Strong

Ciliated cells (tip of cilia)
Staining:

High

Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN

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Specifications

Allele
A*02:01

Class
Class I

MHC Species
Human

Antigen
Mesothelin

Antigen Species
Human

Peptide
VLPLTVAEV

Conjugate
Biotin

Application
MHC Multimer

Target

Antigen Introduction
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Alternative Names
Mesothelin; Pre-Pro-Megakaryocyte-Potentiating Factor; CAK1 Antigen; MPF; Soluble MPF Mesothelin Related Protein; Megakaryocyte Potentiating Factor; SMRP

Gene ID
10232

UniProt ID
Q13421

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Datasheet

Datasheet - MHC-YF239.pdf

MSDS

MSDS - MHC-YF239.pdf

COA

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