Mouse Anti-CCR5 Recombinant Antibody (clone ECL2B-2)
CAT#: VS-0724-YC15
ECL2B-2 is an antibody enzyme that can completely degrade the peptide constituting the extracellular region of CCR-5. The monoclonal antibody ECL2B-2 has the catalytic triad residual structures is collected as the antibody enzyme.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160791-CCR5
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Specifications
- Immunogen
- A peptide (RSSHFPYSQYQFWKNFQTLK) bound to KLH
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human CCR5
- Species Reactivity
- Human
- Clone
- ECL2B-2
- Applications
- ELISA, Catalytic assay
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
- Gene ID
- 1234
- UniProt ID
- O14692
- Long Name
- C-C motif chemokine receptor 5
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
- Post Translation Modifications
- Sulfated on at least 2 of the N-terminal tyrosines.
Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
O-glycosylated, but not N-glycosylated.
Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated.
Also sialylated glycans present which contribute to chemokine binding.
Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
Glycosylation at Ser6 and Ser7.
- Protein Refseq
- NP_000570.1; NP_001093638.1; NP_001381712.1
- Function
- Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
May play a role in the control of granulocytic lineage proliferation or differentiation.
Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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