Mouse Anti-CCR5 Recombinant Antibody (clone ECL2B-2) (CAT#: VS-0724-YC15)

• Immunogen
• A peptide (RSSHFPYSQYQFWKNFQTLK) bound to KLH

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human CCR5

• Species Reactivity
• Human

• Clone
• ECL2B-2

• Applications
• ELISA, Catalytic assay

• Purification
• Protein G purified

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5

• Gene ID
• 1234

• UniProt ID
• O14692

• Long Name
• C-C motif chemokine receptor 5

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane; Multi-pass membrane protein

• Post Translation Modifications
• Sulfated on at least 2 of the N-terminal tyrosines.
  Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
  O-glycosylated, but not N-glycosylated.
  Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated.
  Also sialylated glycans present which contribute to chemokine binding.
  Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
  Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
  Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
  Glycosylation at Ser6 and Ser7.

• Protein Refseq
• NP_000570.1; NP_001093638.1; NP_001381712.1

• Function
• Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
  May play a role in the control of granulocytic lineage proliferation or differentiation.
  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
  (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.

Isotype Control

• MOB-202CQ
• Mouse IgG2a, kappa Isotype Control Antibody

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

• 2ND-042CQ
• Rabbit Anti-Mouse IgG (H&L) Antibody

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