Rabbit Anti-Csf1R Recombinant Antibody (clone R06-5H8) (CAT#: VS3-FY1764)
This anti-M-CSF receptor antibody detected positive in western blot analysis of M-CSF receptor in K562 lysates. The recombinant monoclonal antibody specifically detects human Csf1R. The R06-5H8 is recommended for dilution of target protein by western blot (dilution 1/500-1/1000).
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WB
Figure 1 Anti-Csf1R Antibody (VS3-FY1764) in WB.
The M-CSF Receptor expression in K562 lysates were detected using the anti-M-CSF Receptor by western blot assay.
Specifications
- Immunogen
- Recombinant mouse MCSF receptor protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human Csf1R
- Species Reactivity
- Human
- Clone
- R06-5H8
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 109 kDa, while the observed molecular weight stands at 109 kDa.
- Related Disease
- Alzheimer's diseases
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Colony Stimulating Factor 1 Receptor; McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog; Proto-Oncogene C-Fms; CSF-1 Receptor; CD115 Antigen; EC 2.7.10.1; M-CSF-R; CSF-1R; FMS; Macrophage Colony Stimulating Factor I Receptor
- Gene ID
- 12978
- UniProt ID
- P09581
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-559 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-559 and Tyr-807 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-697 and Tyr-921 is important for interaction with GRB2. Phosphorylation at Tyr-721 is important for interaction with PIK3R1. Phosphorylation at Tyr-721 and Tyr-807 is important for interaction with PLCG2. Phosphorylation at Tyr-974 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation.
- Protein Refseq
- NP_001275634.1; NP_001336665.1; NP_001362249.1; NP_001362250.1; NP_005202.2
- Function
- Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity).
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1863z | Mouse Anti-CSF1R Recombinant Antibody (clone 32G11) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| PABL-055 | Human Anti-CSF1R Recombinant Antibody (clone RG7155) | FC, FuncS | |
| HPAB-0574-CN | Mouse Anti-CSF1R Recombinant Antibody (HPAB-0574-CN) | ELISA, Block | Mouse IgG |
| HPAB-0153-FY | Human Anti-CSF1R Recombinant Antibody (HPAB-0153-FY) | ELISA | Humanized IgG1 |
| HPAB-0177-FY | Human Anti-CSF1R Recombinant Antibody (HPAB-0177-FY) | Block | Human IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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