Anti-CTLA4 Antibody Prodrug, Protease Activated (10D1)

Name: Anti-CTLA4 Antibody Prodrug, Protease Activated (10D1)
SKU: VS-1025-YC196
Rating: 5 (1 reviews)

CAT#: VS-1025-YC196

The Anti-CTLA4 Antibody Prodrug, Protease Activated (10D1) is an antibody prodrug comprised of a recombinant human antibody targeting human CTLA4, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CTLA4 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CTLA4 effectively. CTLA4 is an inhibitory immune checkpoint receptor on T-cells that acts as a powerful "brake" on the immune response. Therapeutic antibodies that block CTLA4 release this brake, enabling a potent, non-specific anti-tumor immune attack.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4

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Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human CTLA4

Target
CTLA4

Species Reactivity
Human, Monkey

Isotype
IgG, kappa

Clone
10D1

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Alternative Names
Cytotoxic T-Lymphocyte-Associated Protein 4; CTLA-4; CD152; CD152 Isoform; CD152 Antigen; CELIAC3; IDDM12; ALPS5; GRD4; GSE

Gene ID
1493

UniProt ID
P16410

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Related Diseases

Rheumatoid Arthritis

Downloadable Resources

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Datasheet

Datasheet - VS-1025-YC196.pdf

MSDS

MSDS - VS-1025-YC196.pdf

COA

Certificate of Analysis Lookup

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DrMAB-986	Recombinant Mouse Anti-Human CTLA4 Antibody F(ab')₂ Fragment, clone ANC152.2/8H5	FC, EIA, FX, Bios	F(ab')2
DrMAB-987	Mouse Anti-CTLA4 Recombinant Antibody (clone ANC152.2/8H5); Fab Fragment	FC, ELISA	Mouse Fab
HPAB-0051-YC-F(E)	Human Anti-CTLA4 Recombinant Antibody (clone 10D1); Fab Fragment	ELISA, Cyt, Block	Human Fab
HPAB-0157-FY-F(E)	Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0157-FY-F(E))	Activ	Humanized Fab
HPAB-N0343-YC-F(E)	Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-N0343-YC-F(E))	FC, ELISA	Human Fab

CAT	Product Name	Application	Type
TAB-067	Anti-Human CTLA4 Recombinant Antibody (TAB-067)	WB, FuncS, IF, Neut, ELISA, FC, IP	IgG1 - kappa
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CAT	Product Name	Application
AGTO-G015E	Anti-CTLA4 immunotoxin (scFv)-PE	Cytotoxicity assay, Function study
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
TAB-083MZ	Anti-Human CTLA4 Recombinant Antibody (TGN2122.H)	ELISA, FC	Humanized antibody
TAB-084MZ	Anti-Human CTLA4 Recombinant Antibody (TGN2422.H)	ELISA, FC	Humanized antibody
TAB-088MZ	Human Anti-CTLA4 Recombinant Antibody (TAB-088MZ)	ELISA	Human IgG
TAB-091MZ	Human Anti-CTLA4 Recombinant Antibody (TAB-091MZ)	ELISA	Human IgG1
TAB-092MZ	Human Anti-CTLA4 Recombinant Antibody (TAB-092MZ)	ELISA	Human IgG1

CAT	Product Name	Application	Type
TAB-085MZ	Anti-Human CTLA4 Recombinant Antibody (TGN2122.C)	ELISA, FC	Chimeric antibody (mouse/human)
TAB-086MZ	Anti-Human CTLA4 Recombinant Antibody (TGN2422.C)	ELISA, FC	Chimeric antibody (mouse/human)
TAB-085MZ-S(P)	Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C)	ELISA, FC	Chimeric antibody (mouse/human)
TAB-086MZ-S(P)	Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.C)	ELISA, FC	Chimeric antibody (mouse/human)
TAB-085MZ-F(E)	Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C)	ELISA, FC	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-087MZ	Mouse Anti-CTLA4 Recombinant Antibody (TAB-087MZ)	ELISA	Mouse IgG
TAB-089MZ	Mouse Anti-CTLA4 Recombinant Antibody (TAB-089MZ)	ELISA	Mouse IgG1
TAB-090MZ	Mouse Anti-CTLA4 Recombinant Antibody (TAB-090MZ)	ELISA	Mouse IgG1
TAB-093MZ	Anti-Human CTLA4 Recombinant Antibody (Mu-26B)	ELISA
TAB-087MZ-S(P)	Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-087MZ-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
MOB-1734MZ	Recombinant Mouse Anti-Human CTLA4 Antibody (clone COJ4)	FC, ICC, IHC-Fr	Mouse antibody
HPAB-0051-YC	Human Anti-CTLA4 Recombinant Antibody (clone 10D1)	ELISA, Cyt, Block	Human IgG, κ
MOB-006LC	Hamster Anti-Ctla4 Recombinant Antibody (clone YC082)	ELISA, FC	Hamster IgG
MOB-061LC	Human Anti-CTLA4 Recombinant Antibody (MOB-061LC)	ELISA, WB, FuncS	Human IgG
HPAB-0157-FY	Human Anti-CTLA4 Recombinant Antibody (HPAB-0157-FY)	Activ	Humanized IgG1, κ

CAT	Product Name	Application	Type
NEUT-567CQ	Mouse Anti-CTLA4 Recombinant Antibody (NEUT-567CQ)	FC, FuncS, Neut, IP, WB	Mouse IgG2a, κ
NEUT-569CQ	Mouse Anti-CTLA4 Recombinant Antibody (clone AS32)	WB, Neut	Mouse IgG1
NEUT-570CQ	Human Anti-CTLA4 Recombinant Antibody (clone YC030)	Neut	Human IgG1, κ
NEUT-572CQ	Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4B9)	FC, Block, ELISA, IP	Hamster IgG
NEUT-573CQ	Rat Anti-Ctla4 Recombinant Antibody (clone 63828)	WB, FC, Neut	Rat IgG2a

CAT	Product Name	Application	Type
NEUT-568CQ	Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10)	FC, Block	Mouse IgG1, κ
NEUT-571CQ	Mouse Anti-CTLA4 Recombinant Antibody (clone BN13)	Block, FC	Mouse IgG2a
NEUT-577CQ	Hamster Anti-Ctla4 Recombinant Antibody (clone MAB0835)	Block, FC	Hamster IgG
NEUT-578CQ	Hamster Anti-Ctla4 Recombinant Antibody (NEUT-578CQ)	Block	Hamster IgG
NEUT-579CQ	Hamster Anti-Ctla4 Recombinant Antibody (clone 9H10)	FC, Block	Hamster IgG

CAT	Product Name	Application	Type
MOR-0855	Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB)	WB	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0051-YC-S(P)	Human Anti-CTLA4 Recombinant Antibody (clone 10D1); scFv Fragment	ELISA, Cyt, Block	Human scFv
HPAB-0157-FY-S(P)	Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0157-FY-S(P))	Activ	Mouse scFv
HPAB-N0343-YC-S(P)	Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-N0343-YC-S(P))	FC, ELISA	Human scFv
HPAB-0749LY-S(P)	Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0749LY-S(P))	FuncS, ELISA	Human scFv
HPAB-0750LY-S(P)	Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0750LY-S(P))	FuncS, ELISA	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-067	Afuco™ Anti-CTLA4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-067)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-206	Afuco™ Anti-CTLA4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-206)	IF, IP, Neut, FuncS, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-AP860-YC	Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP860-YC)	ELISA, Block	Camel VHH
HPAB-AP861-YC	Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP861-YC)	ELISA, Block	Camel VHH
HPAB-AP862-YC	Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP862-YC)	ELISA, Block	Camel VHH
HPAB-AP863-YC	Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP863-YC)	ELISA, Block	Camel VHH
HPAB-AP864-YC	Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP864-YC)	ELISA, Block	Camel VHH

CAT	Product Name	Application	Type
VS-0724-XY22	Mouse Anti-CTLA4 Agonistic Antibody (VS-0724-XY22)	WB, Agonistic assays	Mouse IgG1

CAT	Product Name	Application	Type
VS-0424-XY73	AbPlus™ Anti-CTLA4 Magnetic Beads (14D3)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0225-XY92	CytoStream™ Mouse Anti-CTLA4 Recombinant Antibody (clone BNI3)	FC	Mouse IgG2a, kappa
VS-0225-XY93	CytoStream™ Armenian Hamster Anti-CTLA4 Recombinant Antibody (clone UC10-4F10-11)	FC, IP	Armenian Hamster IgG1, kappa

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VS-0325-FY63	Human Anti-CTLA4 (clone JMW-3B3) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC558	Recombinant Anti-CTLA4 Vesicular Antibody, EV Displayed (VS-0425-YC558)	ELISA, FC, SPR, Neut, Cell-uptake

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VS-0525-XY1763	Anti-CTLA4 Immunohistochemistry Kit	IHC
VS-0525-XY1764	Anti-Mouse CTLA4 Immunohistochemistry Kit	IHC

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VS-0825-YC87	SmartAb™ Recombinant Anti-CTLA4 pH-dependent Antibody (VS-0825-YC87)	WB, IF, Neut, ELISA, FC, IP	Human IgG1 kappa

CAT	Product Name	Application	Type
VS-1025-YC10	Anti-CTLA4 Antibody Prodrug, Protease Activated (Ticilimumab)	ISZ, Cyt, FuncS

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