Anti-CTLA4 immunotoxin (scFv)-Sap (CAT#: AGTO-G015S)

This immunotoxin was achieved by conjugating/fusing the Anti-CTLA4 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CTLA-4-positive T cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Immunosuppressive Agent for Organ Transplant.


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RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Molecule Class
  • scFv-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Immunosuppressive Agent for Organ Transplant

Target

  • Alternative Names
  • CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; saporin; saporin-6; saporin-S12; SAP

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CTLA4"

Human Antibody

CAT Product Name Application Type
TAB-067 Anti-Human CTLA4 Recombinant Antibody (Ipilimumab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG1 - kappa
TAB-206 Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) WB, IF, IP, Neut, FuncS, ELISA, FC IgG2

Immunotoxin

CAT Product Name Application Type
AGTO-G015E Anti-CTLA4 immunotoxin (scFv)-PE Cytotoxicity assay, Function study
AGTO-G015M Anti-CTLA4 immunotoxin (scFv)-Mel Cytotoxicity assay, Function study

Rat Antibody

CAT Product Name Application Type
TAB-195CL Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) ELISA Mouse IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-085MZ Anti-Human CTLA4 Recombinant Antibody (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-F(E) Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ-F(E) Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0855 Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB) WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-067 Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ipilimumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-206 Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ticilimumab (= Tremelimumab)), ADCC Enhanced IF, IP, Neut, FuncS, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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