Anti-CTLA4 immunotoxin (scFv)-Sap (CAT#: AGTO-G015S)

This immunotoxin was achieved by conjugating/fusing the Anti-CTLA4 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CTLA-4-positive T cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Immunosuppressive Agent for Organ Transplant.

Host: Mouse

Applications: This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.


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RNA Expression


Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Molecule Class
  • scFv-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Immunosuppressive Agent for Organ Transplant

Target

  • Alternative Names
  • CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; saporin; saporin-6; saporin-S12; SAP

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CTLA4"

Human Antibody

CAT Product Name Application Type
TAB-067 Anti-Human CTLA4 Recombinant Antibody (Ipilimumab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG1 - kappa
TAB-206 Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) WB, IF, IP, Neut, FuncS, ELISA, FC IgG2

Immunotoxin

CAT Product Name Application Type
AGTO-G015E Anti-CTLA4 immunotoxin (scFv)-PE Cytotoxicity assay, Function study
AGTO-G015M Anti-CTLA4 immunotoxin (scFv)-Mel Cytotoxicity assay, Function study

Rat Antibody

CAT Product Name Application Type
TAB-195CL Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) ELISA Mouse IgG

Humanized Antibody

CAT Product Name Application Type
TAB-083MZ Anti-Human CTLA4 Recombinant Antibody (TGN2122.H) ELISA, FC Humanized antibody
TAB-084MZ Anti-Human CTLA4 Recombinant Antibody (TGN2422.H) ELISA, FC Humanized antibody
TAB-088MZ Human Anti-CTLA4 Recombinant Antibody (TAB-088MZ) ELISA Human IgG
TAB-091MZ Human Anti-CTLA4 Recombinant Antibody (TAB-091MZ) ELISA Human IgG1
TAB-092MZ Human Anti-CTLA4 Recombinant Antibody (TAB-092MZ) ELISA Human IgG1

Chimeric Antibody

CAT Product Name Application Type
TAB-085MZ Anti-Human CTLA4 Recombinant Antibody (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-F(E) Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ-F(E) Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-087MZ Mouse Anti-CTLA4 Recombinant Antibody (TAB-087MZ) ELISA Mouse IgG
TAB-089MZ Mouse Anti-CTLA4 Recombinant Antibody (TAB-089MZ) ELISA Mouse IgG1
TAB-090MZ Mouse Anti-CTLA4 Recombinant Antibody (TAB-090MZ) ELISA Mouse IgG1
TAB-093MZ Anti-Human CTLA4 Recombinant Antibody (Mu-26B) ELISA
TAB-087MZ-S(P) Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-087MZ-S(P)) ELISA Mouse scFv

Recombinant Antibody

CAT Product Name Application Type
MOB-1734MZ Recombinant Mouse Anti-Human CTLA4 Antibody (clone COJ4) FC, ICC, IHC-Fr Mouse antibody
HPAB-0051-YC Human Anti-CTLA4 Recombinant Antibody (clone 10D1) ELISA, Cyt, Block Human IgG, κ
HPAB-0753LY Human Anti-CTLA4 Recombinant Antibody (HPAB-0753LY) FuncS, ELISA Human IgG
HPAB-0754LY Human Anti-CTLA4 Recombinant Antibody (HPAB-0754LY) FuncS, ELISA Human IgG
HPAB-0755LY Human Anti-CTLA4 Recombinant Antibody (HPAB-0755LY) FuncS, ELISA Human IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-567CQ Mouse Anti-CTLA4 Recombinant Antibody (clone 14D3) FC, FuncS, Neut, IP, WB Mouse IgG2a, κ
NEUT-569CQ Mouse Anti-CTLA4 Recombinant Antibody (clone AS32) WB, Neut Mouse IgG1
NEUT-570CQ Human Anti-CTLA4 Recombinant Antibody (clone YC030) Neut Human IgG1, κ
NEUT-572CQ Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4B9) FC, Block, ELISA, IP Hamster IgG
NEUT-580CQ Rat Anti-Ctla4 Recombinant Antibody (clone CBL855) FC, Neut, WB Rat IgG2

Blocking Antibody

CAT Product Name Application Type
NEUT-568CQ Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10) FC, Block Mouse IgG1, κ
NEUT-571CQ Mouse Anti-CTLA4 Recombinant Antibody (clone BN13) Block, FC Mouse IgG2a
NEUT-577CQ Hamster Anti-Ctla4 Recombinant Antibody (clone MAB0835) Block, FC Hamster IgG
NEUT-578CQ Hamster Anti-Ctla4 Recombinant Antibody (clone RYNmCTLA-4) Block Hamster IgG
NEUT-581CQ Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4F10-11) Block, FC, WB Hamster IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0855 Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB) WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0051-YC-F(E) Human Anti-CTLA4 Recombinant Antibody (clone 10D1); Fab Fragment ELISA, Cyt, Block Human Fab
HPAB-0749LY-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0749LY-F(E)) FuncS, ELISA Human Fab
HPAB-0750LY-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0750LY-F(E)) FuncS, ELISA Human Fab
HPAB-0751LY-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0751LY-F(E)) FuncS, ELISA Human Fab
HPAB-0752LY-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0752LY-F(E)) FuncS, ELISA Human Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-067 Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ipilimumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-206 Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ticilimumab (= Tremelimumab)), ADCC Enhanced IF, IP, Neut, FuncS, ELISA ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-2088LY-S(P) Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-2088LY-S(P)) ELISA, FC Human scFv
HPAB-1270WJ-S(P) Mouse Anti-CTLA4 Recombinant Antibody (clone 26); scFv Fragment ELISA, FC Mouse scFv
HPAB-1271WJ-S(P) Human Anti-CTLA4 Recombinant Antibody (clone h26); scFv Fragment ELISA, FC Humanized scFv
HPAB-S0011-YC-S(P) Human Anti-CTLA4 Recombinant Antibody (clone 4.8.1); scFv Fragment ELISA, Block Human scFv
HPAB-S0013-YC-S(P) Human Anti-CTLA4 Recombinant Antibody (clone 6.1.1); scFv Fragment ELISA, Block Human scFv

Single-domain Antibody

CAT Product Name Application Type
HPAB-AP860-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP860-YC) ELISA, Block Camel VHH
HPAB-AP861-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP861-YC) ELISA, Block Camel VHH
HPAB-AP862-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP862-YC) ELISA, Block Camel VHH
HPAB-AP863-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP863-YC) ELISA, Block Camel VHH
HPAB-AP864-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP864-YC) ELISA, Block Camel VHH

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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