Recombinant Anti-CTLA4 Vesicular Antibody, EV Displayed (VS-0425-YC558)
CAT#: VS-0425-YC558
The Recombinant Anti-CTLA4 Vesicular Antibody, EV Displayed (VS-0425-YC558) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CTLA4-expressed cells or tissues. CTLA4 transmits inhibitory signals to T cells, encoded by this immunoglobulin superfamily gene. Variants of CTLA4 are associated with autoimmune diseases.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
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Recombinant Antibody
- Application
- ELISA, FC, SPR, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CTLA4
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Cytotoxic T-lymphocyte associated protein 4
- Biological Process
- Adaptive immunity, Immunity
- Introduction
- This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
- Alternative Names
- CD, CD152, CELIAC3, CTLA-4, GSE, IDDM12
- Gene ID
- 1493
- UniProt ID
- P16410
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Related Diseases
Rheumatoid Arthritis
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| TAB-195CL | Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| NEUT-573CQ | Rat Anti-Ctla4 Recombinant Antibody (clone 63828) | WB, FC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-568CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10) | FC, Block | Mouse IgG1, κ |
| NEUT-571CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone BN13) | Block, FC | Mouse IgG2a |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0753LY-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0753LY-S(P)) | FuncS, ELISA | Human scFv |
| HPAB-0754LY-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0754LY-S(P)) | FuncS, ELISA | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0749LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0749LY) | FuncS, ELISA | Human IgG |
| HPAB-0750LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0750LY) | FuncS, ELISA | Human IgG |
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| HPAB-0752LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0752LY) | FuncS, ELISA | Human IgG |
| HPAB-0753LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0753LY) | FuncS, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0750LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0750LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0751LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0751LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0752LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0752LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0753LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0753LY-F(E)) | FuncS, ELISA | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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