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Anti-CTLA4 immunotoxin (scFv)-Mel (AGTO-G015M)

This immunotoxin was achieved by conjugating/fusing the Anti-CTLA4 scFv to melittin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CTLA-4-positive T cells. Once bind, melittin is subsequently incorporated into the cell by receptor-mediated endocytosis and inhibits activities of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane). It was designed for treatment of Immunosuppressive Agent for Organ Transplant.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Molecule Class
scFv-Mel
Toxin Description
Melittin is the principal active component of apitoxin (bee venom) and is a powerful stimulator of phospholipase A2. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane) and is a cell membrane lytic factor. Melittin is a small peptide with no disulphide bridge; the N-terminal part of the molecule is predominantly hydrophobic and the C-terminal part is hydrophilic and strongly basic.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Immunosuppressive Agent for Organ Transplant
Target
Alternative Names
CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4
Entrez Gene ID
1493
UniProt ID
P16410

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Human Anti-CTLA4 Antibody scFv Fragment (G1)    ( HPAB-0762LY-S(P) )
Recombinant Human Anti-CTLA4 Antibody (G2)    ( HPAB-0763LY )
Mouse Anti-CTLA4 Antibody scFv Fragment (HK44)    ( HPAB-0478LY-S(P) )
Recombinant Human Anti-CTLA4 Antibody scFv Fragment (2C8)    ( HPAB-M0494-YC-S(P) )
Anti-Human CTLA4 Therapeutic Antibody (Hu-26B)    ( TAB-094MZ )
Recombinant Human Anti-CTLA4 Antibody (A2)    ( HPAB-0750LY )
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