Anti-CTLA4 immunotoxin (scFv)-Mel (AGTO-G015M)
This immunotoxin was achieved by conjugating/fusing the Anti-CTLA4 scFv to melittin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CTLA-4-positive T cells. Once bind, melittin is subsequently incorporated into the cell by receptor-mediated endocytosis and inhibits activities of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane). It was designed for treatment of Immunosuppressive Agent for Organ Transplant.
Specifications
- Host
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-Mel
- Toxin Description
- Melittin is the principal active component of apitoxin (bee venom) and is a powerful stimulator of phospholipase A2. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane) and is a cell membrane lytic factor. Melittin is a small peptide with no disulphide bridge; the N-terminal part of the molecule is predominantly hydrophobic and the C-terminal part is hydrophilic and strongly basic.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Immunosuppressive Agent for Organ Transplant
Target
- Alternative Names
- CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4
- Entrez Gene ID
- 1493
- UniProt ID
- P16410
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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