AbPlus™ Anti-CTLA4 Magnetic Beads (14D3)

Name: AbPlus™ Anti-CTLA4 Magnetic Beads (14D3)
SKU: VS-0424-XY73
Rating: 5 (1 reviews)

CAT#: VS-0424-XY73

The AbPlus Anti-CTLA4 Magnetic Beads (14D3) is an innovative affinity resin which is bound with anti-CTLA4 specific antibody (14D3). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of CTLA4 protein under native and denaturing conditions.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4

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Specifications

Applications
Immunoprecipitation, Protein Purification

Matrix
Magrose bead (> 50 μmol/mL gel)

Bead Ligand
Anti-CTLA4 specific antibody (14D3)

Target
CTLA4

Target Species
Human, Monkey

Antibody Clone
14D3

Bead Capacity
20-30 mg/mL binding antibody

Bead size
10-37 μm

Stability
pH 2-14

Format
20% Suspension

Buffer
PBS, pH 7.4, with 1% BSA

Preservative
0.03% Proclin 300

Storage
Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

Application Notes
The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

Introduction
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Alternative Names
CTLA4; cytotoxic T-lymphocyte associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3

Gene ID
1493

UniProt ID
P16410

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Related Diseases

Rheumatoid Arthritis

Downloadable Resources

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Datasheet

Datasheet - VS-0424-XY73.pdf

MSDS

MSDS - VS-0424-XY73.pdf

COA

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