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CTLA4
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Related Diseases
Rheumatoid Arthritis
- Recombinant Mouse Anti-CTLA4 Antibody (MOB-0317MC)
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- Species Reactivity: Human, Rat
- Application: ELISA, FACS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Mouse Anti-CTLA4 Recombinant Antibody (clone 14D3) (NEUT-567CQ)
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- Species Reactivity: Human, Monkey
- Type: Mouse IgG2a, κ
- Application: FC, FuncS, Neut, IP, WB
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- Human Anti-CTLA4 Recombinant Antibody (clone YC030) (NEUT-570CQ)
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: Neut
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- Mouse Anti-CTLA4 Recombinant Antibody (clone BN13) (NEUT-571CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Block, FC
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- Mouse Anti-CTLA4 Recombinant Antibody (clone AS32) (NEUT-569CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, Neut
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- Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10) (NEUT-568CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, Block
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- Rat Anti-Ctla4 Recombinant Antibody (clone 63828) (NEUT-573CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: WB, FC, Neut
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- Rat Anti-Ctla4 Recombinant Antibody (clone 6G10) (NEUT-574CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: FC, Neut, WB
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- Mouse Anti-Ctla4 Recombinant Antibody (clone 9D9) (NEUT-575CQ)
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- Species Reactivity: Mouse
- Type: Mouse IgG2b
- Application: WB, Neut
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- Hamster Anti-Ctla4 Recombinant Antibody (clone 9H10) (NEUT-579CQ)
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: FC, Block
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- Rat Anti-Ctla4 Recombinant Antibody (clone CBL855) (NEUT-580CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: FC, Neut, WB
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- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0757LY-S(P)) (HPAB-0757LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
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- Mouse Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-1660LY-F(E)) (HPAB-1660LY-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, Block, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0751LY-F(E)) (HPAB-0751LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody (HPAB-0753LY) (HPAB-0753LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0756LY-S(P)) (HPAB-0756LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0750LY-F(E)) (HPAB-0750LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0755LY-S(P)) (HPAB-0755LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody (HPAB-0752LY) (HPAB-0752LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0754LY-S(P)) (HPAB-0754LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0749LY-F(E)) (HPAB-0749LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody (HPAB-0751LY) (HPAB-0751LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0753LY-S(P)) (HPAB-0753LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0752LY-S(P)) (HPAB-0752LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
Compare
- Mouse Anti-CTLA4 Recombinant Antibody (HPAB-1660LY) (HPAB-1660LY)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, Block, ELISA
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- Human Anti-CTLA4 Recombinant Antibody (HPAB-0750LY) (HPAB-0750LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS, ELISA
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- Human Anti-CTLA4 Recombinant Antibody (HPAB-N0343-YC) (HPAB-N0343-YC)
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: FC, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0751LY-S(P)) (HPAB-0751LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody (HPAB-0749LY) (HPAB-0749LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0750LY-S(P)) (HPAB-0750LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
Compare
- Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-1660LY-S(P)) (HPAB-1660LY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, Block, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0749LY-S(P)) (HPAB-0749LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-N0343-YC-F(E)) (HPAB-N0343-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-N0343-YC-S(P)) (HPAB-N0343-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, ELISA
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- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0157-FY-F(E)) (HPAB-0157-FY-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Activ
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- Human Anti-CTLA4 Recombinant Antibody (HPAB-0157-FY) (HPAB-0157-FY)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: Activ
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- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0157-FY-S(P)) (HPAB-0157-FY-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Activ
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- Anti-Human CTLA4 Recombinant Antibody Fab Fragment (Mu-26B) (TAB-093MZ-F(E))
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- Application: ELISA
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- Human Anti-CTLA4 Recombinant Antibody (clone 10D1); Fab Fragment (HPAB-0051-YC-F(E))
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- Species Reactivity: Human, Monkey
- Type: Human Fab
- Application: ELISA, Cyt, Block
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- Anti-Human CTLA4 Recombinant Antibody Fab Fragment (Hu-26B) (TAB-094MZ-F(E))
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- Type: Humanized antibody
- Application: ELISA
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- Human Anti-CTLA4 Recombinant Antibody (clone 10D1) (HPAB-0051-YC)
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- Species Reactivity: Human, Monkey
- Type: Human IgG, κ
- Application: ELISA, Cyt, Block
Compare
- Human Anti-CTLA4 Recombinant Antibody (clone 10D1); scFv Fragment (HPAB-0051-YC-S(P))
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- Species Reactivity: Human, Monkey
- Type: Human scFv
- Application: ELISA, Cyt, Block
Compare
- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (TAB-092MZ-F(E)) (TAB-092MZ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Anti-Human CTLA4 Recombinant Antibody (Hu-26B) (TAB-094MZ)
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- Type: Humanized antibody
- Application: ELISA
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- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (TAB-091MZ-F(E)) (TAB-091MZ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Anti-Human CTLA4 Recombinant Antibody scFv Fragment (Hu-26B) (TAB-094MZ-S(P))
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- Type: Humanized antibody
- Application: ELISA
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- Anti-Human CTLA4 Recombinant Antibody (Mu-26B) (TAB-093MZ)
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- Application: ELISA
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- Mouse Anti-CTLA4 Recombinant Antibody; Fab Fragment (TAB-090MZ-F(E)) (TAB-090MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Anti-Human CTLA4 Recombinant Antibody scFv Fragment (Mu-26B) (TAB-093MZ-S(P))
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- Application: ELISA
Compare
- Mouse Anti-CTLA4 Recombinant Antibody; Fab Fragment (TAB-089MZ-F(E)) (TAB-089MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (TAB-088MZ-F(E)) (TAB-088MZ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
Compare
- Mouse Anti-CTLA4 Recombinant Antibody; Fab Fragment (TAB-087MZ-F(E)) (TAB-087MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2422.C) (TAB-086MZ-F(E))
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- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) (TAB-085MZ-F(E))
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- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.C) (TAB-086MZ-S(P))
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- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2422.H) (TAB-084MZ-F(E))
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- Type: Humanized antibody
- Application: ELISA, FC
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- Anti-CTLA4 immunotoxin (scFv)-Mel (AGTO-G015M)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) (TAB-085MZ-S(P))
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- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
Compare
- Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.H) (TAB-084MZ-S(P))
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- Type: Humanized antibody
- Application: ELISA, FC
Compare
- Anti-CTLA4 immunotoxin (scFv)-Sap (AGTO-G015S)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
Compare
- Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.H) (TAB-083MZ-F(E))
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- Type: Humanized antibody
- Application: ELISA, FC
Compare
- Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.H) (TAB-083MZ-S(P))
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- Type: Humanized antibody
- Application: ELISA, FC
Compare
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG2
- Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Compare
- Anti-CTLA4 immunotoxin (scFv)-PE (AGTO-G015E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Compare
- Human Anti-CTLA4 Recombinant Antibody (HPAB-0755LY) (HPAB-0755LY)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0759LY-S(P)) (HPAB-0759LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody (clone CBL007LY) (HPAB-0477LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: Block, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0752LY-F(E)) (HPAB-0752LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0758LY-S(P)) (HPAB-0758LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS, ELISA
Compare
- Human Anti-CTLA4 Recombinant Antibody (HPAB-0754LY) (HPAB-0754LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS, ELISA
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