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CTLA4

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This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, FuncS, IF, Neut, ELISA, FC, IP
Derivation:
Human
Species Reactivity:
Human
Type:
IgG2
Application:
WB, IF, IP, Neut, FuncS, ELISA, FC
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Type:
Humanized antibody
Application:
ELISA, FC
Type:
Humanized antibody
Application:
ELISA, FC
Type:
Chimeric antibody (mouse/human)
Application:
ELISA, FC
Type:
Chimeric antibody (mouse/human)
Application:
ELISA, FC
Application:
SDS-PAGE, ELISA
Species Reactivity:
Human
Type:
Antibody
Type:
Humanized antibody
Application:
ELISA, FC
Type:
Humanized antibody
Application:
ELISA, FC
Type:
Chimeric antibody (mouse/human)
Application:
ELISA, FC
Type:
Chimeric antibody (mouse/human)
Application:
ELISA, FC
Application:
SDS-PAGE, ELISA
Type:
Humanized antibody
Application:
SDS-PAGE, ELISA
Type:
Humanized antibody
Application:
ELISA
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