Anti-DKK1 Antibody Prodrug, Protease Activated (VS-1025-YC142)
CAT#: VS-1025-YC142
The Anti-DKK1 Antibody Prodrug, Protease Activated (VS-1025-YC142) is an antibody prodrug comprised of a recombinant human antibody targeting human DKK1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to DKK1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to DKK1 effectively. The DKK (Dickkopf) family proteins are secreted antagonists of the Wnt signaling pathway, generally acting as tumor suppressors. DKK1 is notably overexpressed in multiple myeloma, while loss of DKK3 function is a common event in various solid tumors.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human DKK1
- Target
- DKK1
- Species Reactivity
- Human
- Isotype
- IgG
- Epitope
- Discontinuous epitopes (aa 98-104, aa 107-121, aa 127-140)
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
- Alternative Names
- Dickkopf WNT Signaling Pathway Inhibitor 1; HDkk-1; DKK-1; SK; Dickkopf-1
- Gene ID
- 22943
- UniProt ID
- O94907
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS |
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| TAB-193MZ | Anti-Human DKK1 Recombinant Antibody (huMabJC18) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
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| TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
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| TAB-195MZ | Human Anti-DKK1 Recombinant Antibody (TAB-195MZ) | In vivo efficacy assay | Human IgG |
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| TAB-196MZ | Rat Anti-DKK1 Recombinant Antibody (TAB-196MZ) | FuncS | Rat IgG |
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| TAB-193MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) | ELISA | Humanized antibody |
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| TAB-194MZ-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-194MZ-S(P)) | ELISA | Mouse scFv |
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| TAB-193MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) | ELISA | Humanized antibody |
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| TAB-010MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-010MZ-VHH) | ELISA | Single domain antibody |
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| TAB-012MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-012MZ-VHH) | ELISA | Single domain antibody |
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| HPAB-0279-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0279-YC) | Block, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0278-YC-S(P)) | ELISA, Block, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0279-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0279-YC-S(P)) | Block, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0280-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0280-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0278-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0278-YC-F(E)) | ELISA, Block, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
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| HPAB-0279-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0279-YC-F(E)) | Block, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
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| HPAB-0280-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0280-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
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| HPAB-0096-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0096-FY-F(E)) | FuncS | Human Fab |
| CAT | Product Name | Application | Type |
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| HPAB-0107-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0107-FY-F(E)) | FuncS | Human Fab |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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