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DKK1

Anti-DKK1 Products

APC-H-2Kd/Human DKK1 (RFLAVFTMM) MHC Tetramer (MHC-CN0221)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: RFLAVFTMM
- Conjugate: APC
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Anti-Human DKK1 Recombinant Antibody (BHQ880) (TAB-214CL)
- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
- Application: IHC, ELISA, IB
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Afuco™ Anti-Human DKK1 ADCC Recombinant Antibody (BHQ880), ADCC Enhanced (AFC-202CL)
- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) (TAB-193MZ-F(E))
- Type: Humanized antibody
- Application: ELISA
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Human Anti-DKK1 Recombinant Antibody (HPAB-0278-YC) (HPAB-0278-YC)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, Block, FuncS
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Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-31) (TAB-199MZ-F(E))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-59) (TAB-200MZ-F(E))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-80) (TAB-201MZ-F(E))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Human Anti-DKK1 Recombinant Antibody (HPAB-0279-YC) (HPAB-0279-YC)
- Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit
- Type: Human IgG
- Application: Block, FuncS
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Human Anti-DKK1 Recombinant Antibody (HPAB-0280-YC) (HPAB-0280-YC)
- Species Reactivity: Human, Mouse, Monkey
- Type: Human IgG
- Application: ELISA
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Recombinant Mouse anti-Human DKK1 Monoclonal antibody (EML1238) (MOB-0054CT)
- Species Reactivity: Human
- Application: WB
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Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) (NEUT-703CQ)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: Neut
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PE-H-2Kd/Human DKK1 (RFLAVFTMM) MHC Tetramer (MHC-CN0222)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: RFLAVFTMM
- Conjugate: PE
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APC-A*02:01/Human DKK1 (RLFDQAFGL) MHC Tetramer (MHC-CN0229)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: RLFDQAFGL
- Conjugate: APC
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PE-A*02:01/Human DKK1 (RLFDQAFGL) MHC Tetramer (MHC-CN0230)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: RLFDQAFGL
- Conjugate: PE
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APC-A*02:01/Human DKK1 (ALGGHPLLGV) MHC Tetramer (MHC-CN0013)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: ALGGHPLLGV
- Conjugate: APC
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PE-A*02:01/Human DKK1 (ALGGHPLLGV) MHC Tetramer (MHC-CN0014)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: ALGGHPLLGV
- Conjugate: PE
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APC-A*02:01/Human DKK1 (ILYPGGNKV) MHC Tetramer (MHC-CN0121)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: ILYPGGNKV
- Conjugate: APC
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PE-A*02:01/Human DKK1 (ILYPGGNKV) MHC Tetramer (MHC-CN0122)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: ILYPGGNKV
- Conjugate: PE
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Rabbit Anti-DKK1 Recombinant Antibody (clone CBACN-197) (MRO-0479-CN)
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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Rabbit Anti-DKK1 Polyclonal Antibody (MRO-1816-CN) (MRO-1816-CN)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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Human Anti-DKK1 Recombinant Antibody (HPAB-670-FY) (HPAB-670-FY)
- Species Reactivity: Human
- Type: Human IgG, λ
- Application: ELISA
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Mouse Anti-Dkk1 Recombinant Antibody (clone YC091) (MOB-013LC)
- Derivation: Chimeric (mouse/rat)
- Species Reactivity: Rat
- Type: Chimeric (mouse/rat) IgG
- Application: ELISA
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Human Anti-DKK1 Recombinant Antibody (HPAB-0096-FY) (HPAB-0096-FY)
- Species Reactivity: Human
- Type: Human IgG, κ
- Application: FuncS
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Human Anti-DKK1 Recombinant Antibody (HPAB-0107-FY) (HPAB-0107-FY)
- Species Reactivity: Human
- Type: Human IgG, λ
- Application: FuncS
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Anti-Human DKK1 Recombinant Antibody (huMabJC18) (TAB-193MZ)
- Type: Humanized antibody
- Application: ELISA
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Rabbit Anti-DKK1 Recombinant Antibody (clone 1D12) (ZG-0086U)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB
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Rabbit Anti-DKK1 Recombinant Antibody (VS3-CJ185) (VS3-CJ185)
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, FC
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Mouse Anti-DKK1 Recombinant Antibody (clone 2H2) (VS3-XY579)
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
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Human Anti-DKK1 Recombinant Antibody (clone Sirexatamab) (VS-0723-WK25)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG4
- Application: FC
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Rabbit Anti-DKK1 Recombinant Antibody (VS-0723-WK110) (VS-0723-WK110)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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Rabbit Anti-DKK1 Recombinant Antibody (clone R07-6J6) (VS3-XY3332)
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
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Mouse Anti-DKK1 Recombinant Antibody (ZG-0479F) (ZG-0479F)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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Mouse Anti-DKK1 Recombinant Antibody (HPAB-0757-FY) (HPAB-0757-FY)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody (HPAB-0758-FY) (HPAB-0758-FY)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody (HPAB-0759-FY) (HPAB-0759-FY)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody (HPAB-0760-FY) (HPAB-0760-FY)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody (HPAB-0761-FY) (HPAB-0761-FY)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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APC-H-2Kd/Human DKK1 (VFTMMALCSL) MHC Tetramer (MHC-CN0315)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: VFTMMALCSL
- Conjugate: APC
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PE-H-2Kd/Human DKK1 (VFTMMALCSL) MHC Tetramer (MHC-CN0316)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: VFTMMALCSL
- Conjugate: PE
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APC-A*02:01/Human DKK1 (YLGAAGATYV) MHC Tetramer (MHC-CN0357)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: YLGAAGATYV
- Conjugate: APC
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PE-A*02:01/Human DKK1 (YLGAAGATYV) MHC Tetramer (MHC-CN0358)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: YLGAAGATYV
- Conjugate: PE
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APC-B*07:02/Human DKK1 (YPGGNKVQT) MHC Tetramer (MHC-CN0371)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: YPGGNKVQT
- Conjugate: APC
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PE-B*07:02/Human DKK1 (YPGGNKVQT) MHC Tetramer (MHC-CN0372)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: YPGGNKVQT
- Conjugate: PE
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APC-A*02:01/Human DKK1 (KLTRHRVTYV) MHC Tetramer (MHC-CN0147)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: KLTRHRVTYV
- Conjugate: APC
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PE-A*02:01/Human DKK1 (KLTRHRVTYV) MHC Tetramer (MHC-CN0148)
- Class: Class I
- Antigen: DKK1
- Antigen Species: Human
- Peptide: KLTRHRVTYV
- Conjugate: PE
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Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH1-10) (TAB-197MZ-F(E))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-18) (TAB-198MZ-F(E))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH1-10) (TAB-197MZ-S(P))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH2-18) (TAB-198MZ-S(P))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH2-31) (TAB-199MZ-S(P))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH2-59) (TAB-200MZ-S(P))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Anti-Human DKK1 Recombinant Antibody scFv Fragment (RH2-80) (TAB-201MZ-S(P))
- Derivation: Human phage display library
- Type: Human antibody
- Application: WB
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Human Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-195MZ-F(E)) (TAB-195MZ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: In vivo efficacy assay
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Anti-Human DKK1 Recombinant Antibody (RH2-80) (TAB-201MZ)
- Derivation: Human phage display library
- Type: Human antibody
- Application: FuncS, Inhib
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Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) (TAB-193MZ-S(P))
- Type: Humanized antibody
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody (clone 25A8) (MOB-1882z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA, FC, ICC, IF, IHC
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Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-194MZ-S(P)) (TAB-194MZ-S(P))
- Type: Mouse scFv
- Application: ELISA
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Anti-Mouse DKK1 Recombinant Antibody scFv Fragment (JC18) (TAB-192MZ-S(P))
- Species Reactivity: Rat, Human
- Application: ELISA
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Rat Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-196MZ-F(E)) (TAB-196MZ-F(E))
- Species Reactivity: Human
- Type: Rat Fab
- Application: ELISA
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Anti-Mouse DKK1 Recombinant Antibody Fab Fragment (JC18) (TAB-192MZ-F(E))
- Species Reactivity: Rat, Human
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0757-FY-F(E)) (HPAB-0757-FY-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0758-FY-F(E)) (HPAB-0758-FY-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0759-FY-F(E)) (HPAB-0759-FY-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0760-FY-F(E)) (HPAB-0760-FY-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0761-FY-F(E)) (HPAB-0761-FY-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0757-FY-S(P)) (HPAB-0757-FY-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0758-FY-S(P)) (HPAB-0758-FY-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0759-FY-S(P)) (HPAB-0759-FY-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0760-FY-S(P)) (HPAB-0760-FY-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0761-FY-S(P)) (HPAB-0761-FY-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Llama Anti-DKK1 Recombinant Antibody (HPAB-1510-FY) (HPAB-1510-FY)
- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA
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Llama Anti-DKK1 Recombinant Antibody (HPAB-1511-FY) (HPAB-1511-FY)
- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) (TAB-194MZ)
- Type: Mouse IgG
- Application: ELISA
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Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0096-FY-S(P)) (HPAB-0096-FY-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
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Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0279-YC-F(E)) (HPAB-0279-YC-F(E))
- Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit
- Type: Human Fab
- Application: Block, FuncS
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Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0280-YC-F(E)) (HPAB-0280-YC-F(E))
- Species Reactivity: Human, Mouse, Monkey
- Type: Human Fab
- Application: ELISA
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Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0107-FY-S(P)) (HPAB-0107-FY-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
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Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0096-FY-F(E)) (HPAB-0096-FY-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS
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Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0107-FY-F(E)) (HPAB-0107-FY-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS
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Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-670-FY-S(P)) (HPAB-670-FY-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-670-FY-F(E)) (HPAB-670-FY-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0278-YC-S(P)) (HPAB-0278-YC-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Block, FuncS
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Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0279-YC-S(P)) (HPAB-0279-YC-S(P))
- Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit
- Type: Human scFv
- Application: Block, FuncS
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Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0280-YC-S(P)) (HPAB-0280-YC-S(P))
- Species Reactivity: Human, Mouse, Monkey
- Type: Human scFv
- Application: ELISA
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Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0278-YC-F(E)) (HPAB-0278-YC-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Block, FuncS
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Anti-Human DKK1 Recombinant Antibody (TAB-013MZ-VHH) (TAB-013MZ-VHH)
- Type: Single domain antibody
- Application: ELISA
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Anti-Human DKK1 Recombinant Antibody (TAB-010MZ-VHH) (TAB-010MZ-VHH)
- Derivation: Phage library
- Type: Single domain antibody
- Application: ELISA
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Anti-Human DKK1 Recombinant Antibody (TAB-011MZ-VHH) (TAB-011MZ-VHH)
- Derivation: Phage library
- Type: Single domain antibody
- Application: ELISA
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Anti-Human DKK1 Recombinant Antibody (TAB-012MZ-VHH) (TAB-012MZ-VHH)
- Derivation: Phage library
- Type: Single domain antibody
- Application: ELISA
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Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-194MZ-F(E)) (TAB-194MZ-F(E))
- Type: Mouse Fab
- Application: ELISA
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Anti-Mouse DKK1 Recombinant Antibody (JC18) (TAB-192MZ)
- Species Reactivity: Rat, Human
- Application: ELISA, FuncS
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Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone DS991AB) (MOR-0991)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IF, IHC-P, WB
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Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone SI210DS) (MOR-4137)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: Neut
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Anti-DKK1 (clone BHQ880) Recombinant Antibody Coupled Liposome (VS-1024-FY145) (VS-1024-FY145)
- Antibody Host: Human
- Antibody Reactivity: Human
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Mouse Anti-DKK1 Recombinant Antibody (clone CBL196HM) (VS7-HM817)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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Anti-DKK1 Immunohistochemistry Kit (VS-0525-XY2001)
- Species Reactivity: Human
- Target: DKK1
- Application: IHC
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Anti-Mouse DKK1 Immunohistochemistry Kit (VS-0525-XY2002)
- Species Reactivity: Mouse
- Target: DKK1
- Application: IHC
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Anti-Human DKK1 Immunohistochemistry Kit (VS-0525-XY2003)
- Species Reactivity: Human, Yeast
- Target: DKK1
- Application: IHC
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Recombinant Anti-DKK1 Biparatopic Antibody, Tandem scFv (Clone RH2-31 x Clone RH2-80) (VS-0525-YC46)
- Species Reactivity: Human
- Target: DKK1
- Type: Tandem scFv
- Application: Inhib
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For Research Use Only. Not For Clinical Use.

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Prostatic glandular cells, Basal prostatic cells, Endometrial stromal cells, Urothelial cells, Pancreatic endocrine cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)

Interaction

Interacts with LRP6 (PubMed:11448771, PubMed:17804805, PubMed:20093360, PubMed:22000856). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (PubMed:19746449). Forms a ternary complex with LRP6 and KREM1 (PubMed:27524201). Interacts with KREM1 (PubMed:17804805).

Molecular function

Developmental protein

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Related Signaling Pathways

Canonical Wnt Signaling Pathway

Non-Canonical Wnt Signaling Pathway