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For Research Use Only. Not For Clinical Use.
Secreted
Cell type enhanced (Prostatic glandular cells, Basal prostatic cells, Endometrial stromal cells, Urothelial cells, Pancreatic endocrine cells)
Not detected in immune cells
Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Interacts with LRP6 (PubMed:11448771, PubMed:17804805, PubMed:20093360, PubMed:22000856). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (PubMed:19746449). Forms a ternary complex with LRP6 and KREM1 (PubMed:27524201). Interacts with KREM1 (PubMed:17804805).
Developmental protein