Anti-Human DKK1 Recombinant Antibody (BHQ880) (CAT#: TAB-214CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human DKK1. BHQ880 is a human neutralizing IgG1 anti-DKK1 monoclonal antibody, that is being investigated for its impact on multiple myeloma-related bone disease and as an agent with potential anti-myeloma activity. BHQ880 in combination with zoledronic acid and anti-myeloma therapy was well tolerated and demonstrated potential clinical activity in patients with relapsed or refractory multiple myeloma.
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DB
Figure 1 Anti-Human DKK1 Therapeutic Antibody (TAB-214CL) in DB
Dot Blot analysis of TAB-214CL was performed by coating with human DKK1 protein (His tag).
TAB-214CL incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-Human IgG was used as a secondary antibody (1: 2000)
WB
Figure 2 Anti-Human DKK1 Therapeutic Antibody (TAB-214CL) in WB
Western blot analysis of TAB-214CL was performed with human DKK1 protein onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-214CL and HRP goat anti-Human IgG was used as a secondary antibody (1: 2000). Chemiluminescent detection was performed.
Lane 1: Reduced antigen (0.1 μg)
Lane 2: Reduced antigen (0.3 μg)
Lane 3: Reduced antigen (0.6 μg)
ELISA
Figure 3 Anti-Human DKK1 Therapeutic Antibody (TAB-214CL) in ELISA
ELISA analysis of TAB-214CL was performed by coating with human DKK1 protein (His tag). Then blocked with BSA and incubated with TAB-214CL. The HRP-conjugated goat anti-Human IgG was used as a secondary antibody (1: 2000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- IHC, ELISA, IB
- Related Disease
- Bone-related Diseases; Multiple Myeloma
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Applications
- Application Notes
- This antibody has been reported for use in Immunohistochemistry, Enzyme-Linked Immunosorbent Assay and Immunoblot.
Target
- Alternative Names
- DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1
- Gene ID
- 22943
- UniProt ID
- I1W660
Related Resources
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS | |
| TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
| TAB-196MZ | Rat Anti-DKK1 Recombinant Antibody (TAB-196MZ) | FuncS | Rat IgG |
| TAB-192MZ-S(P) | Anti-Mouse DKK1 Recombinant Antibody scFv Fragment (JC18) | ELISA | |
| TAB-194MZ-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-194MZ-S(P)) | ELISA | Mouse scFv |
Customer Reviews and Q&As
Customer Review
Q&As
Excellent Value
This antibody is highly economical when you take into account its excellent quality and function. Excellent value given the cost.
Ideal for Research
This is the perfect research antibody, and our lab has shown it to be dependable. It successfully satisfies all of our research demands.
Strongly Suggested
To anyone looking for a dependable, highly specific solution for a range of applications, I heartily suggest this antibody.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-214CL, RRID: AB_3111876)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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