SmartAb™ Recombinant Anti-DKK1 pH-dependent Antibody (VS-0825-YC99)
CAT#: VS-0825-YC99
The anti-DKK1 pH-dependent antibody (VS-0825-YC99) targets human DKK1 in a pH-dependent manner, with its affinity remaining high at neutral pH but weakening at a lower pH, such as within the acidic environment of endosomes. The anti-DKK1 acid-switched antibody was engineered by incorporating histidine residues into its variable regions. The introduction of histidine substitutions within its Complementarity-Determining Regions (CDRs) enables pH-responsive antigen binding, which leads to enhanced DKK1 clearance. The antibody operates in a cyclical manner, binding DKK1 in the extracellular fluid and releasing it in acidified endosomes. Human DKK1, or Dickkopf-1, is a secreted protein that acts as an antagonist of the Wnt signaling pathway. It plays a key role in embryonic development and is frequently overexpressed in various cancers, promoting tumor growth and metastasis.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
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Specifications
- Immunogen
- Recombinant human DKK1 protein.
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human DKK1
- Species Reactivity
- Human
- Applications
- ELISA, Block
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- Dickkopf WNT Signaling Pathway Inhibitor 1; HDkk-1; DKK-1; SK; Dickkopf (Xenopus Laevis) Homolog 1; Dickkopf 1 Homolog (Xenopus Laevis); Dickkopf Related Protein-1; Dickkopf-Like Protein 1; Dickkopf 1 Homolog; Dickkopf-1 Like; Dickkopf-1
- Gene ID
- 22943
- UniProt ID
- O94907
- Long Name
- Dickkopf WNT Signaling Pathway Inhibitor 1
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| TAB-214CL | Anti-Human DKK1 Recombinant Antibody (BHQ880) | IHC, ELISA, IB | Antibody |
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| TAB-198MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-18) | WB | Human antibody |
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| CAT | Product Name | Application | Type |
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| TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS | |
| TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
| TAB-192MZ-F(E) | Anti-Mouse DKK1 Recombinant Antibody Fab Fragment (JC18) | ELISA | |
| TAB-194MZ-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-194MZ-F(E)) | ELISA | Mouse Fab |
| TAB-196MZ-F(E) | Rat Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-196MZ-F(E)) | ELISA | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193MZ | Anti-Human DKK1 Recombinant Antibody (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-010MZ-VHH) | ELISA | Single domain antibody |
| TAB-011MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-011MZ-VHH) | ELISA | Single domain antibody |
| TAB-012MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-012MZ-VHH) | ELISA | Single domain antibody |
| HPAB-1510-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1510-FY) | ELISA | Llama VHH |
| HPAB-1511-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1511-FY) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-703CQ | Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0991 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone DS991AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0278-YC) | ELISA, Block, FuncS | Human IgG |
| HPAB-0279-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0279-YC) | Block, FuncS | Human IgG |
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| HPAB-670-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-670-FY) | ELISA | Human IgG, λ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0278-YC-F(E)) | ELISA, Block, FuncS | Human Fab |
| HPAB-0279-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0279-YC-F(E)) | Block, FuncS | Human Fab |
| HPAB-0280-YC-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0280-YC-F(E)) | ELISA | Human Fab |
| HPAB-670-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-670-FY-F(E)) | ELISA | Human Fab |
| HPAB-0760-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0760-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0096-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0096-FY-S(P)) | FuncS | Human scFv |
| HPAB-0107-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0107-FY-S(P)) | FuncS | Human scFv |
| HPAB-670-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-670-FY-S(P)) | ELISA | Human scFv |
| HPAB-0757-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0757-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0758-FY-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0758-FY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2001 | Anti-DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2002 | Anti-Mouse DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2003 | Anti-Human DKK1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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