Recombinant Anti-DKK1 Biparatopic Antibody, Tandem scFv (Clone RH2-31 x Clone RH2-80)
CAT#: VS-0525-YC46
The recombinant Anti-DKK1 biparatopic antibody, tandem scFv (Clone RH2-31 x Clone RH2-80), is developed to target two distinct epitopes on DKK1. The antibody is based on a tandem scFv format, combining the RH2-31 scFv targeting amino acids 159-266, fused N-terminally to the RH2-80 scFv targeting the cysteine-rich-domain-2 of the human DKK1 protein.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
❮
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Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human DKK1
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- RH2-31
- Clone 2
- RH2-80
- Epitope 1
- aa 159-266
- Epitope 2
- Cysteine-rich-domain-2 (CRD2)
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- Inhib
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Dickkopf WNT Signaling Pathway Inhibitor 1
Target
- Introduction
- This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
- Alternative Names
- DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1
- Gene ID
- 22943
- UniProt ID
- I1W660
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1882z | Mouse Anti-DKK1 Recombinant Antibody (clone 25A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-0278-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0278-YC) | ELISA, Block, FuncS | Human IgG |
| HPAB-0279-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0279-YC) | Block, FuncS | Human IgG |
| HPAB-0280-YC | Human Anti-DKK1 Recombinant Antibody (HPAB-0280-YC) | ELISA | Human IgG |
| HPAB-0096-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-0096-FY) | FuncS | Human IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS | |
| TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
| TAB-192MZ-S(P) | Anti-Mouse DKK1 Recombinant Antibody scFv Fragment (JC18) | ELISA | |
| TAB-194MZ-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-194MZ-S(P)) | ELISA | Mouse scFv |
| TAB-196MZ-S(P) | Rat Anti-DKK1 Recombinant Antibody; scFv Fragment (TAB-196MZ-S(P)) | ELISA | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193MZ | Anti-Human DKK1 Recombinant Antibody (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195MZ | Human Anti-DKK1 Recombinant Antibody (TAB-195MZ) | In vivo efficacy assay | Human IgG |
| TAB-197MZ | Anti-Human DKK1 Recombinant Antibody (RH1-10) | Inhib | Human antibody |
| TAB-198MZ | Anti-Human DKK1 Recombinant Antibody (RH2-18) | ELISA, FuncS, Inhib | Human antibody |
| TAB-199MZ | Anti-Human DKK1 Recombinant Antibody (RH2-31) | Inhib | Human antibody |
| TAB-200MZ | Anti-Human DKK1 Recombinant Antibody (RH2-59) | Inhib | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-010MZ-VHH) | ELISA | Single domain antibody |
| TAB-011MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-011MZ-VHH) | ELISA | Single domain antibody |
| TAB-012MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-012MZ-VHH) | ELISA | Single domain antibody |
| TAB-013MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-013MZ-VHH) | ELISA | Single domain antibody |
| HPAB-1510-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1510-FY) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-703CQ | Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0991 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone DS991AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| MOR-4137 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone SI210DS) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0278-YC-S(P)) | ELISA, Block, FuncS | Human scFv |
| HPAB-0279-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0279-YC-S(P)) | Block, FuncS | Human scFv |
| HPAB-0280-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0280-YC-S(P)) | ELISA | Human scFv |
| HPAB-0096-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0096-FY-S(P)) | FuncS | Human scFv |
| HPAB-670-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-670-FY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0096-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0096-FY-F(E)) | FuncS | Human Fab |
| HPAB-0107-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0107-FY-F(E)) | FuncS | Human Fab |
| HPAB-670-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-670-FY-F(E)) | ELISA | Human Fab |
| HPAB-0760-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0760-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0761-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0761-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2001 | Anti-DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2002 | Anti-Mouse DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2003 | Anti-Human DKK1 Immunohistochemistry Kit | IHC |
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