Recombinant Anti-DKK1 Biparatopic Antibody, Tandem scFv (Clone RH2-31 x Clone RH2-80) (CAT#: VS-0525-YC46)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human DKK1

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• RH2-31

• Clone 2
• RH2-80

• Epitope 1
• aa 159-266

• Epitope 2
• Cysteine-rich-domain-2 (CRD2)

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• Inhib

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Dickkopf WNT Signaling Pathway Inhibitor 1

• Introduction
• This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

• Alternative Names
• DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1

• Gene ID
• 22943

• UniProt ID
• I1W660

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