Anti-Human DKK1 Recombinant Antibody (RH2-18)
CAT#: TAB-198MZ
This antibody, specific for Dkk-1, can be potentially used as an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway for treating bone disorders which results in a loss in bone, for example, osteoporosis.
Published Data
Gene Expression
Inhib
Figure 1 shows Eu-Dkk-1 binding to HEK293hLrp5 cells and inhibitory activity of anti-Dkk-1 antibodies RH2-10, RH2-18, RH2-31, RH2-59, and RH2-80 at various concentrations.
ELISA
Figure 2 shows the result for RH2-18 antibodies retitrated using an extended dose range. The results shows that for this assay format the RH2-18 antibodies had an effective dose of about 5 nM.
FuncS
Figure 3 shows that distal femur bone mineral density (BMD) was increased 5.2 to 8.7% in a dose effect fashion by RH2-18 antibodies in the dose range 0.5 to 5 mg/kg. Error bars = SEM. N=I l /group.
FuncS
Figure 4 shows a xenograph model for tumor growth and the effect of the antibody on tumor growth.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107984-DKK1
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Specifications
- Host Species
- Human
- Derivation
- Human phage display library
- Type
- Human antibody
- Specificity
- Human
- Clone
- RH2-18
- Applications
- ELISA, FuncS, Inhib
- Related Disease
- A loss in bone, such as osteoporosis
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.
Target
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Outstanding Signal-to-Noise
For our fluorescent microscopy experiments, the signal-to-noise ratio was good. incredibly dependable and efficient.
Comprehensive Procedures
The provided protocols were simple to understand and adhere to. They made the process of incorporating the antibody into our operations quite easy.
Superior Batch Reliability
This antibody has been ordered in numerous batches, and the quality and performance of each batch has been consistent.
Q&As
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How can I ensure that my antibody is contamination-free?
A: To avoid contamination, buy from reliable vendors, test for endotoxins, and handle items with sterile practices.
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Do antibodies detect post-translational modifications?
A: Specific antibodies can target post-translational changes including as phosphorylation, ubiquitination, and glycosylation.
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What are isotype regulates, and why do they matter?
A: To measure non-specific binding, isotype controls-antibodies belonging to the same class and subclass but with insignificant specificity-are employed.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone RH2-18"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1882z | Mouse Anti-DKK1 Recombinant Antibody (clone 25A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| MOB-013LC | Mouse Anti-Dkk1 Recombinant Antibody (clone YC091) | ELISA | Chimeric (mouse/rat) IgG |
| MRO-0479-CN | Rabbit Anti-DKK1 Recombinant Antibody (clone CBACN-197) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-670-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-670-FY) | ELISA | Human IgG, λ |
| ZG-0086U | Rabbit Anti-DKK1 Recombinant Antibody (clone 1D12) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS | |
| TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
| TAB-192MZ-F(E) | Anti-Mouse DKK1 Recombinant Antibody Fab Fragment (JC18) | ELISA | |
| TAB-194MZ-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-194MZ-F(E)) | ELISA | Mouse Fab |
| TAB-196MZ-F(E) | Rat Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-196MZ-F(E)) | ELISA | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193MZ | Anti-Human DKK1 Recombinant Antibody (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) | ELISA | Humanized antibody |
| TAB-193MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195MZ-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-195MZ-F(E)) | In vivo efficacy assay | Human Fab |
| TAB-197MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH1-10) | WB | Human antibody |
| TAB-198MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-18) | WB | Human antibody |
| TAB-199MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-31) | WB | Human antibody |
| TAB-200MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-59) | WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-010MZ-VHH) | ELISA | Single domain antibody |
| TAB-011MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-011MZ-VHH) | ELISA | Single domain antibody |
| TAB-012MZ-VHH | Anti-Human DKK1 Recombinant Antibody (TAB-012MZ-VHH) | ELISA | Single domain antibody |
| HPAB-1510-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1510-FY) | ELISA | Llama VHH |
| HPAB-1511-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1511-FY) | ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-703CQ | Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0991 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone DS991AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| MOR-4137 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone SI210DS) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0278-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0278-YC-S(P)) | ELISA, Block, FuncS | Human scFv |
| HPAB-0279-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0279-YC-S(P)) | Block, FuncS | Human scFv |
| HPAB-0280-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0280-YC-S(P)) | ELISA | Human scFv |
| HPAB-0096-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0096-FY-S(P)) | FuncS | Human scFv |
| HPAB-0107-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0107-FY-S(P)) | FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0096-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0096-FY-F(E)) | FuncS | Human Fab |
| HPAB-0107-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-0107-FY-F(E)) | FuncS | Human Fab |
| HPAB-670-FY-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (HPAB-670-FY-F(E)) | ELISA | Human Fab |
| HPAB-0760-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0760-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0761-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0761-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2001 | Anti-DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2002 | Anti-Mouse DKK1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2003 | Anti-Human DKK1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC46 | Recombinant Anti-DKK1 Biparatopic Antibody, Tandem scFv (Clone RH2-31 x Clone RH2-80) | Inhib | Tandem scFv |
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