Anti-Human DKK1 Recombinant Antibody (RH2-18) (CAT#: TAB-198MZ)
This antibody, specific for Dkk-1, can be potentially used as an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway for treating bone disorders which results in a loss in bone, for example, osteoporosis.
Specific Inquiry
Inhib
Figure 1 shows Eu-Dkk-1 binding to HEK293hLrp5 cells and inhibitory activity of anti-Dkk-1 antibodies RH2-10, RH2-18, RH2-31, RH2-59, and RH2-80 at various concentrations.
ELISA
Figure 2 shows the result for RH2-18 antibodies retitrated using an extended dose range. The results shows that for this assay format the RH2-18 antibodies had an effective dose of about 5 nM.
FuncS
Figure 3 shows that distal femur bone mineral density (BMD) was increased 5.2 to 8.7% in a dose effect fashion by RH2-18 antibodies in the dose range 0.5 to 5 mg/kg. Error bars = SEM. N=I l /group.
FuncS
Figure 4 shows a xenograph model for tumor growth and the effect of the antibody on tumor growth.
Specifications
- Host Species
- Human
- Derivation
- Human phage display library
- Type
- Human antibody
- Specificity
- Human
- Clone
- RH2-18
- Applications
- ELISA, FuncS, Inhib
- Related Disease
- A loss in bone, such as osteoporosis
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.
Target
- Alternative Names
- DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1
- Gene ID
- 22943
- UniProt ID
- I1W660
Related Resources
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone RH2-18"
See other products for "DKK1"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Mouse Antibody Products
Humanized Antibody Products
Human Antibody Products
Single Domain Antibody Products
Neutralizing Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
MHC Tetramer Products for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1882z | Mouse Anti-DKK1 Recombinant Antibody (clone 25A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-670-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-670-FY) | ELISA | Human IgG, λ |
| ZG-0479F | Mouse Anti-DKK1 Recombinant Antibody (ZG-0479F) | WB, ELISA | Mouse IgG |
| VS-0723-WK25 | Human Anti-DKK1 Recombinant Antibody (clone Sirexatamab) | FC | Human IgG4 |
| VS-0723-WK110 | Rabbit Anti-DKK1 Recombinant Antibody (VS-0723-WK110) | ELISA, FC | Rabbit IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Outstanding Signal-to-Noise
For our fluorescent microscopy experiments, the signal-to-noise ratio was good. incredibly dependable and efficient.
Comprehensive Procedures
The provided protocols were simple to understand and adhere to. They made the process of incorporating the antibody into our operations quite easy.
Superior Batch Reliability
This antibody has been ordered in numerous batches, and the quality and performance of each batch has been consistent.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, FuncS
Application: ELISA, FC
Application: SPR, Inhib, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, Neut, Inhib
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
