Anti-Human DKK1 Recombinant Antibody (huMabJC18) (CAT#: TAB-193MZ)
This antibody that binds to Dkk-1 can be potentially used for treating diseases, conditions and disorders, such as bone disorders, which result in a loss of bone.
Specific Inquiry
Figure 1 shows the specificity of binding of JC18 to human homologues Dkk-1, Dkk-3 and Dkk-4.
JC18 showed weak binding to human Dkk-4 and no binding to human Dkk-3 up to 5 ug/ml.
Figure 2 shows a graph of observed and model predicted free/partially free huMabJC18 concentrations versus time following weekly intravenous administration of huMabJC18 to Sprague-Dawley rats.
Symbols represent the mean observed data (±SD) and lines represent the predicted profiles from the model.
Figure 3 show graphs of observed and model predicted free/partially free huMabJC18 concentrations versus time following single intravenous administration of huMabJC18 to Cynomolgous monkeys.
(A) Male monkeys. (B) Female monkeys. Symbols represent the observed individual monkey data and lines represent the predicted profiles from the model.
Figure 4 shows a graph of mean osteocalcin concentrations (±SE) at 1.5 and 2.5 weeks post first dose following weekly intravenous administration of huMabJC18 to Sprague-Dawley rats. * indicates p<0.05 vs. vehicle
Figure 5 shows a graph of predicted free Dkk-1 concentrations in humans following subcutaneous administration of huMabJC18 1/month for 6 months.
Three different doses were tested: 0.003 mg/kg which represents 1/10 of MABEL or a no effect dose, 0.03 mg/kg which represents MABEL and 3.57 mg/kg which represents predicted efficacious dose for osteoporosis.
Figure 6 shows a graph of predicted free huMabJC18 concentrations in humans following subcutaneous administration of huMabJC18 1/month for 6 months.
Three different doses were tested: 0.003 mg/kg which represents 1/10 of MABEL or a no effect dose, 0.03 mg/kg which represents MABEL and 3.57 mg/kg which represents predicted efficacious dose for osteoporosis. Anticipated Limit of Quantitation (LOQ) of the bioanalytical assay is shown to represent the futility of dosing lower than predicted MABEL.
Figure 7 shows a graph of receptor occupancy calculations for huMabJC18 vs.
predicted human dose based on (1) steady state equilibrium method (Duff, 2006) and (2) mechanistic PK/PD (TMDD) model.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- huMabJC18
- Applications
- ELISA, FuncS
- Related Disease
- Bone disorders such as a loss of bone mass
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1
- Gene ID
- 22943
- UniProt ID
- I1W660
Related Resources
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-214CL | Anti-Human DKK1 Recombinant Antibody (BHQ880) | IHC, ELISA, IB | Antibody |
| TAB-195MZ | Human Anti-DKK1 Recombinant Antibody (TAB-195MZ) | In vivo efficacy assay | Human IgG |
| TAB-197MZ | Anti-Human DKK1 Recombinant Antibody (RH1-10) | Inhib | Human antibody |
| TAB-198MZ | Anti-Human DKK1 Recombinant Antibody (RH2-18) | ELISA, FuncS, Inhib | Human antibody |
| TAB-199MZ | Anti-Human DKK1 Recombinant Antibody (RH2-31) | Inhib | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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