Mouse Anti-ENG Recombinant Antibody (clone PT1795)
CAT#: VS3-CJ727
This product is a mouse antibody that recognizes human ENG (CD105).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1823_F9_38_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11862/158146_A_2_7_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to nuclear bodies & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1777_G1_13_cr59632eeaa8e82_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1759_C2_13_cr594b6f97edc10_blue_red_green.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/156475_A_9_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG
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Specifications
- Immunogen
- Synthesized peptide derived from human CD105 (Endoglin)
- Host Species
- Mouse
- Type
- Mouse IgG2b, κ
- Specificity
- Human ENG (CD105)
- Species Reactivity
- Human
- Clone
- PT1795
- Applications
- WB, IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500-1:2000), Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- END; HHT1; ORW1
- Gene ID
- 2022
- UniProt ID
- P17813
- Cellular Localization
- Cell membrane, Membrane
- Protein Refseq
- NP_000109.1; NP_001108225.1; NP_001265067.1
- Function
- Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529).
Required for normal structure and integrity of adult vasculature (PubMed:7894484).
Regulates the migration of vascular endothelial cells (PubMed:17540773).
Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).
May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).
May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830).
Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529).
Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
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Recommended Dilution Buffer
- CAT
- Product Name
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| HPAB-0448-FY-F(E) | Rat Anti-ENG Recombinant Antibody; Fab Fragment (HPAB-0448-FY-F(E)) | ELISA, Inhib, FuncS | Rat Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0713-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 6B10); scFv Fragment | WB, FC | Human scFv |
| HPAB-0714-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 4.120); scFv Fragment | WB, FC | Human scFv |
| HPAB-0137-WJ-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (HPAB-0137-WJ-S(P)) | ELISA | Humanized scFv |
| HPAB-0448-FY-S(P) | Rat Anti-ENG Recombinant Antibody; scFv Fragment (HPAB-0448-FY-S(P)) | ELISA, Inhib, FuncS | Rat scFv |
| HPAB-J0071-YC-S(P) | Mouse Anti-ENG Recombinant Antibody (clone AP020/YC); scFv Fragment | ELISA, WB, ICC, IHC, IF, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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