Afuco™ Anti-EPHA3 ADCC Recombinant Antibody (Ifabotuzumab), ADCC Enhanced (CAT#: AFC-TAB-430CQ)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to EPHA3. Ifabotuzumab is a humanized monoclonal antibody that can be potentially used in the treatment of Myelodysplastic syndrome, Myelofibrosis, Cancer.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane, cytosol & actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69390/1819_G10_18_cr59f32f9e0f828_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane, cytosol & actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69390/1819_G10_18_cr59f32f9e0f828_selected.jpg
Figure 2 IHC staining of human parathyroid gland
(Immunohistochemical staining of human parathyroid gland shows cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/ihc_selected.jpg
(Immunohistochemical staining of human parathyroid gland shows cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_B_9_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_B_9_5.jpg
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_8_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_8_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_9_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_9_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_5_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_5_6.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enriched (AF22)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000044524-EPHA3
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000044524-EPHA3
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Specificity
- Human EPHA3
- Species Reactivity
- Human
- Clone
- Ifabotuzumab
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- Generic Name
- Ifabotuzumab
- Related Disease
- Myelodysplastic syndrome, Myelofibrosis, Cancer
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- EPH Receptor A3; Tyrosine-Protein Kinase Receptor ETK1; Eph-Like Tyrosine Kinase 1; EPH-Like Kinase 4; EC 2.7.10.1; TYRO4; HEK4; ETK1; ETK; EK4; HEK; Testicular Tissue Protein Li 64; TYRO4 Protein Tyrosine Kinase; Tyrosine-Protein Kinase TYRO4; Human Embryo Kinase 1; Human Embryo Kinase; EC 2.7.10; EphA3
- Gene ID
- 2042
- UniProt ID
- P29320
Related Resources
Please refer to Ifabotuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ifabotuzumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ifabotuzumab"
Anti-Human EPHA3 Recombinant Antibody (Ifabotuzumab)Recombinant monoclonal antibody to EPHA3. Ifabotuzumab is a humanized monoclonal antibody that can be potentially used in the treatment of Myelodysplastic syndrome, Myelofibrosis, Cancer.
See other products for "EPHA3"
Select a product category from the dropdown menu below to view related products.
Please select product type
Recombinant Antibody
Human Antibody
Fc Glycosylation
Low- or Non-fucosylated Oligosaccharide
Rabbit Monoclonal Antibody
Humanized Antibody
scFv Fragment Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2640z | Mouse Anti-EPHA3 Recombinant Antibody (clone 18F1) | WB, ELISA | Mouse IgG2b |
| MOB-0651CT | Recombinant Mouse anti-Human EPHA3 Monoclonal antibody (EML056) | ICC/IF, WB | |
| HPAB-0007-LS | Human Anti-EPHA3 Recombinant Antibody (HPAB-0007-LS) | ELISA, FC | Human IgG κ |
| ZG-0294J | Mouse Anti-EPHA3 Recombinant Antibody (ZG-0294J) | WB, ELISA | Mouse IgG |
| VS-0723-WK252 | Rabbit Anti-EPHA3 Recombinant Antibody (VS-0723-WK252) | ELISA, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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