Mouse Anti-FCGR3A Recombinant Antibody (VS3-FY2702) (CAT#: VS3-FY2702)
The anti-FCGR3A antibody has been developed to target human CD16 protein. It cross-reacts with human. This monoclonal antibody proves valuable in disease research related to Immunodeficiency 20 and Herpes Zoster.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_B_7_5.jpg
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_B_7_5.jpg
Figure 2 Lung
(Macrophages
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_A_1_4.jpg
(Macrophages
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_A_1_4.jpg
Figure 3 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_A_9_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_A_9_8.jpg
Figure 4 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000203747-FCGR3A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000203747-FCGR3A
Figure 4 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000203747-FCGR3A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000203747-FCGR3A
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Fc fragment of IgG receptor IIIa of human
- Species Reactivity
- Human
- Applications
- WB, IHC
- Conjugate
- Unconjugated, FITC
- Related Disease
- Immunodeficiency 20 and Herpes Zoster
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Fc Fragment Of IgG Receptor IIIa; Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a); Fc Gamma Receptor IIIa; IgG Fc Receptor III-2; Fc-Gamma RIII-Alpha; Fc-Gamma RIIIa; Fc-Gamma RIII; CD16a Antigen; FCRIIIA; FCR-10; FCRIII; FCGR3; CD16A; IGFR3; FCG3
- Gene ID
- 2214
- UniProt ID
- P08637
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Glycosylated.
Contains high mannose- and complex-type oligosaccharides.
Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
Undergoes rapid ectodomain shedding upon NK cell stimulation.
The soluble form is produced by a proteolytic cleavage mediated by ADAM17.
Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.
Phosphorylated at RSSTR motif by PKC.
The relevant physiological PKCs might be PRKCI, PRKCG, PRKCE, PRKCH and PRKCQ.
Glycosylation at Asn56, Asn63, Asn92, Asn180, and Asn187
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 6 sites
- Protein Refseq
- XP_047305399.1; XP_047305400.1; NP_000560.7; NP_001121064.2; NP_001121065.1
- Function
- Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation.
Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC (PubMed:25786175, 24412922).
Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (PubMed:9916693, 29967280).
Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-978 | Recombinant Mouse Anti-Human FCGR3A Antibody F(ab')2 Fragment, clone 3G8 | FC | F(ab')2 |
| DrMAB-979 | Mouse Anti-FCGR3A Recombinant Antibody (clone 3G8); Fab Fragment | FC, ELISA, Inhib, ADCC | Mouse Fab |
| HPAB-M0271-YC-F(E) | Human Anti-FCGR3A Recombinant Antibody (clone M/YC-27); Fab Fragment | ELISA | Human Fab |
| HPAB-N0090-YC-F(E) | Human Anti-FCGR3A Recombinant Antibody; Fab Fragment (HPAB-N0090-YC-F(E)) | FuncS | Human Fab |
| HPAB-0787-FY-S(P) | Human Anti-FCGR3A Recombinant Antibody (clone A2); Fab Fragment | Cyt | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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