Mouse Anti-FCGR3A Recombinant Antibody (VS3-FY2702)
CAT#: VS3-FY2702
The anti-FCGR3A antibody has been developed to target human CD16 protein. It cross-reacts with human. This monoclonal antibody proves valuable in disease research related to Immunodeficiency 20 and Herpes Zoster.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_B_7_5.jpg
Normal Tissue
Figure 2 Lung
Macrophages
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_A_1_4.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32435/70986_A_9_8.jpg
RNA Expression
Figure 4 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000203747-FCGR3A
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Fc fragment of IgG receptor IIIa of human
- Species Reactivity
- Human
- Applications
- WB, IHC
- Conjugate
- Unconjugated, FITC
- Related Disease
- Immunodeficiency 20 and Herpes Zoster
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Fc Fragment Of IgG Receptor IIIa; Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a); Fc Gamma Receptor IIIa; IgG Fc Receptor III-2; Fc-Gamma RIII-Alpha; Fc-Gamma RIIIa; Fc-Gamma RIII; CD16a Antigen; FCRIIIA; FCR-10; FCRIII; FCGR3; CD16A; IGFR3; FCG3
- Gene ID
- 2214
- UniProt ID
- P08637
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Glycosylated.
Contains high mannose- and complex-type oligosaccharides.
Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
Undergoes rapid ectodomain shedding upon NK cell stimulation.
The soluble form is produced by a proteolytic cleavage mediated by ADAM17.
Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.
Phosphorylated at RSSTR motif by PKC.
The relevant physiological PKCs might be PRKCI, PRKCG, PRKCE, PRKCH and PRKCQ.
Glycosylation at Asn56, Asn63, Asn92, Asn180, and Asn187
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 6 sites
- Protein Refseq
- XP_047305399.1; XP_047305400.1; NP_000560.7; NP_001121064.2; NP_001121065.1
- Function
- Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation.
Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC (PubMed:25786175, 24412922).
Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (PubMed:9916693, 29967280).
Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FCGR3A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-979 | Mouse Anti-FCGR3A Recombinant Antibody (clone 3G8); Fab Fragment | FC, ELISA, Inhib, ADCC | Mouse Fab |
| HPAB-M0271-YC-F(E) | Human Anti-FCGR3A Recombinant Antibody (clone M/YC-27); Fab Fragment | ELISA | Human Fab |
| HPAB-N0090-YC-F(E) | Human Anti-FCGR3A Recombinant Antibody; Fab Fragment (HPAB-N0090-YC-F(E)) | FuncS | Human Fab |
| HPAB-0787-FY-S(P) | Human Anti-FCGR3A Recombinant Antibody (clone A2); Fab Fragment | Cyt | Human Fab |
| HPAB-0788-FY-S(P) | Human Anti-FCGR3A Recombinant Antibody (clone B2); Fab Fragment | Cyt | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-063 | Recombinant Anti-Human FCGR3A VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| HPAB-1025WJ | Recombinant Camelid Anti-FCGR3A Single Domain Antibody | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-040WM | Anti-Human FCGR3A Recombinant Antibody (hu3G8) | ELISA | Humanized Antibody |
| TAB-040WM-S(P) | Anti-Human FCGR3A Recombinant Antibody scFv Fragment (hu3G8) | ELISA | Humanized Antibody |
| TAB-040WM-F(E) | Anti-Human FCGR3A Recombinant Antibody Fab Fragment (hu3G8) | ELISA | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-041WM | Anti-Human FCGR3A Recombinant Antibody (ch3G8) | ELISA | Chimeric Antibody (human/mouse) |
| TAB-041WM-S(P) | Anti-Human FCGR3A Recombinant Antibody scFv Fragment (ch3G8) | ELISA | Chimeric Antibody (human/mouse) |
| TAB-041WM-F(E) | Anti-Human FCGR3A Recombinant Antibody Fab Fragment (ch3G8) | ELISA | Chimeric Antibody (human/mouse) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0275MC | Recombinant Mouse Anti-Human FCGR3A Antibody. | FC, IP, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-797CQ | Mouse Anti-FCGR3A Recombinant Antibody (clone 3G8) | FC, IHC-Fr, ICC, IP, Stim, Costim, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-798CQ | Mouse Anti-FCGR3A Recombinant Antibody (clone B73.1) | FC, FuncS, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1275 | Hi-Affi™ Rabbit Anti-FCGR3A Recombinant Antibody (clone DS1275AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0271-YC | Human Anti-FCGR3A Recombinant Antibody (clone M/YC-27) | ELISA | Human IgG1 |
| HPAB-N0090-YC | Human Anti-FCGR3A Recombinant Antibody (HPAB-N0090-YC) | FuncS | Human IgG |
| HPAB-0787-FY | Human Anti-FCGR3A Recombinant Antibody (clone A2) | Cyt | Human IgG1 |
| HPAB-0788-FY | Human Anti-FCGR3A Recombinant Antibody (clone B2) | Cyt | Human IgG1 |
| VS3-QX419 | Mouse Anti-FCGR3A Recombinant Antibody (clone 441CT4.2.1) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0271-YC-S(P) | Human Anti-FCGR3A Recombinant Antibody (clone M/YC-27); scFv Fragment | ELISA | Human scFv |
| HPAB-N0090-YC-S(P) | Human Anti-FCGR3A Recombinant Antibody; scFv Fragment (HPAB-N0090-YC-S(P)) | FuncS | Human scFv |
| HPAB-0787-FY-F(E) | Human Anti-FCGR3A Recombinant Antibody (clone A2); scFv Fragment | Cyt | Human scFv |
| HPAB-0788-FY-F(E) | Human Anti-FCGR3A Recombinant Antibody (clone B2); scFv Fragment | Cyt | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1558 | AbPlus™ Anti-Fcgr3a Magnetic Beads (VS-0724-YC1558) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY80 | Mouse Anti-NHP FCGR3A Recombinant Antibody (clone 3G8) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY213 | Human Anti-FCGR3A (clone hu3G8) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC388 | CytoStream™ Rabbit Anti-FCGR3A Polyclonal Antibody (VS13-YC388) | WB, ELISA, IHC-P, IHC-Fr, FC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC21 | Recombinant Anti-FCGR3A Vesicular Antibody, EV Displayed (VS-0425-YC21) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2483 | Anti-Mouse FCGR3A Immunohistochemistry Kit | IHC | |
| VS-0525-XY2485 | Anti-Rat FCGR3A Immunohistochemistry Kit | IHC |
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