Anti-FGF2 (clone W24V179) Recombinant Antibody Coupled Liposome (VS-1024-FY180)
CAT#: VS-1024-FY180
The application of anti-FGF2 antibody-conjugated liposomes in melanoma demonstrates good targeting ability and therapeutic potential. These liposomes specifically recognize and bind to FGF2 expressed on melanoma cells, thereby enhancing the accumulation of drugs. Studies have shown that anti-FGF2 antibody-conjugated liposomes can effectively inhibit the proliferation and metastasis of tumor cells. This novel targeted therapy strategy offers new insights and potential clinical applications for the treatment of melanoma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/641_G7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Immunohistochemical staining of human caudate shows nuclear positivity in glia.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/65502/1336_684_200x200.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/640_G7_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/642_G7_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_B_9_5.jpg
Normal Tissue
Figure 6 Caudate
Glial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_B_8_7.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_A_8_3.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_A_9_5.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, hTERT-HME1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138685-FGF2
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V179
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically designed to target fibroblast growth factor 2 (FGF2). FGF2, also known as basic fibroblast growth factor, plays a crucial role in various biological processes, including cell proliferation, differentiation, and angiogenesis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FGF2
- Introduction
- The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
- Alternative Names
- Fibroblast Growth Factor 2; Fibroblast Growth Factor 2 (Basic); Heparin-Binding Growth Factor 2; HBGF-2; FGF-2; BFGF
- Full Name
- Fibroblast Growth Factor 2
- Gene ID
- 2247
- UniProt ID
- P09038
- Sequence Similarities
- Belongs to the heparin-binding growth factors family.
- Cellular Localization
- Secreted, Nucleus
- Post Translation Modifications
- Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion. ( P09038-FGF2_HUMAN )
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing. ( P09038-FGF2_HUMAN )
Modification sites at PhosphoSitePlus ( P09038 )
Modification sites at neXtProt
- Protein Refseq
- NP_001348594.1; NP_001997.5
- Function
- Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044).
Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677).
Binds to integrin ITGAV:ITGB3 (PubMed:28302677).
Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, 8663044).
Functions as a potent mitogen in vitro.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS-0525-XY2523 | Anti-Human FGF2 Immunohistochemistry Kit | IHC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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