Mouse Anti-FLT1 Recombinant Antibody (VS3-FY2710)
CAT#: VS3-FY2710
This remarkable mouse recombinant monoclonal antibody is proficient in binding to FLT1 protein, a calculated weight of 150.8 kDa. It exhibits cross-reactivity with human, mouse and rat. This monoclonal antibody is potential for conducting research on Pre-Eclampsia and Corneal Neovascularization. The antibody can be utilized for detection of FLT1 by Western Blot.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/90_G3_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/1368_A5_2_blue_green.jpg
Normal Tissue
Figure 3 Testis
Peritubular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/142518_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, HMC-1, HUVEC TERT2, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102755-FLT1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Fms related tyrosine kinase 1 of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 150.8 kDa.
- Related Disease
- Pre-Eclampsia and Corneal Neovascularization
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Target
- Alternative Names
- Fms Related Tyrosine Kinase 1; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); Vascular Endothelial Growth Factor Receptor 1; Tyrosine-Protein Kinase Receptor FLT; Tyrosine-Protein Kinase FRT; Fms-Like Tyrosine Kinase 1; EC 2.7.10.1
- Gene ID
- 2321
- UniProt ID
- P17948
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Endosome
- Post Translation Modifications
- N-glycosylated.
Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.
Autophosphorylated on tyrosine residues upon ligand binding.
- Protein Refseq
- NP_001153392.1; NP_001153502.1; NP_001153503.1; NP_002010.2
- Function
- Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity).
May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
Can promote endothelial cell proliferation, survival and angiogenesis in adulthood.
Its function in promoting cell proliferation seems to be cell-type specific.
Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
Modulates KDR signaling by forming heterodimers with KDR.
Ligand binding leads to the activation of several signaling cascades.
Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C.
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Related Diseases
Rheumatoid Arthritis
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| TAB-008CQ | Mouse Anti-FLT1 Recombinant Antibody (TAB-008CQ) | ELISA, FC | Mouse IgG |
| TAB-008CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-008CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-008CQ-F(E) | Mouse Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-008CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009CQ | Human Anti-FLT1 Recombinant Antibody (TAB-009CQ) | ELISA | Chimeric antibody (mouse/human) |
| TAB-009CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-009CQ-S(P)) | ELISA | Mouse scFv |
| TAB-009CQ-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-009CQ-F(E)) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0785-CN-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1606LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1606LY-S(P)) | ELISA | Human scFv |
| HPAB-1607LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1607LY-S(P)) | ELISA | Human scFv |
| HPAB-1609LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1609LY-S(P)) | ELISA | Human scFv |
| HPAB-1610LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1610LY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1606LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1606LY) | ELISA | Human IgG |
| HPAB-1607LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1607LY) | ELISA | Human IgG |
| HPAB-1609LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1609LY) | ELISA | Human IgG |
| HPAB-1610LY | Human Anti-FLT1 Recombinant Antibody (HPAB-1610LY) | ELISA | Human IgG |
| MRO-1579-CN | Rabbit Anti-FLT1 Recombinant Antibody (clone CBACN-579) | WB, IF, IHC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| MHC-CN0674 | APC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN0675 | FITC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN0676 | A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-YF771 | A*02:01/Human VEGFR1 (GVLLWEIFSL) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1700-FY-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone CA0071-Z2ZA-01171); Fab Fragment | ELISA | Mouse Fab |
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| HPAB-1702-FY-S(P) | Human Anti-FLT1 Recombinant Antibody (clone 6F9); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-1703-FY-S(P) | Human Anti-FLT1 Recombinant Antibody (clone 13G12); Fab Fragment | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS-0525-XY2581 | Anti-Mouse FLT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2582 | Anti-Zebrafish FLT1 Immunohistochemistry Kit | IHC | |
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