Rabbit Anti-IL10 Recombinant Antibody (clone R08-3B8)
CAT#: VS3-XY3392
The recombinant rabbit antibody is specific for IL10 (Interleukin 10), which controls the inflammatory response of macrophages by reprogramming essential metabolic pathways. IL10 targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines. The antibody specifically reacts with human IL10. It has been tested using Western Blot, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71391/167603_B_9_5.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71391/167603_A_6_6.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (HMC-1, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136634-IL10
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IL10
- Species Reactivity
- Human
- Clone
- R08-3B8
- Applications
- WB, ICC, IF, FC
- Related Disease
- Graft-Versus-Host Disease; Human Immunodeficiency Virus Type 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- CSIF; TGIF; GVHDS; IL-10; IL10A
- Gene ID
- 3586
- UniProt ID
- P22301
- Long Name
- Interleukin 10
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn134 (NX_P22301 [NX_P22301-1])
Glycosylation from GlyGen (P22301) 1 site
- Protein Refseq
- NP_001369553.1; NP_000563.1
- Function
- Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608).
In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.
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Related Diseases
Asthma
Inflammatory Bowel Diseases
Systemic Lupus Erythematosus
Autoimmune Thyroid Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| NEUT-1098CQ | Mouse Anti-IL10 Recombinant Antibody (clone CBL397) | Neut, WB | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1103CQ | Mouse Anti-IL10 Recombinant Antibody (clone B-S10) | Block | Mouse IgG1 |
| NEUT-1116CQ | Rat Anti-Il10 Recombinant Antibody (clone 2A5) | Block, ELISA, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1118CQ | Rat Anti-Il10 Recombinant Antibody (clone 5C69) | ELISA, Neut | Rat IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1786 | Rabbit Anti-IL10 Recombinant Antibody (clone DS1786AB) | WB | Rabbit IgG |
| MOR-4606 | Rabbit Anti-Il10 Recombinant Antibody (clone TH119DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0609LC | Rat Anti-IL10 Recombinant Antibody (clone 9D7) | ELISA | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022-YC-S(P) | Human Anti-IL10 Recombinant Antibody; scFv Fragment (HPAB-0022-YC-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0223CQ-S(P) | Mouse Anti-IL10 Recombinant Antibody (clone B-N10); scFv Fragment | ELISA, FC, Block | Mouse scFv |
| HPAB-0224CQ-S(P) | Human Anti-IL10 Recombinant Antibody (clone BT-063); scFv Fragment | ELISA, FC, Block | Humanized scFv |
| HPAB-0842-FY-F(E) | Human Anti-IL10 Recombinant Antibody; Fab Fragment (HPAB-0842-FY-F(E)) | ELISA | Humanized Fab |
| HPAB-0843-FY-F(E) | Human Anti-IL10 Recombinant Antibody; Fab Fragment (HPAB-0843-FY-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022-YC-F(E) | Human Anti-IL10 Recombinant Antibody; Fab Fragment (HPAB-0022-YC-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0223CQ-F(E) | Mouse Anti-IL10 Recombinant Antibody (clone B-N10); Fab Fragment | ELISA, FC, Block | Mouse Fab |
| HPAB-0224CQ-F(E) | Human Anti-IL10 Recombinant Antibody (clone BT-063); Fab Fragment | ELISA, FC, Block | Humanized Fab |
| HPAB-0842-FY-S(P) | Human Anti-IL10 Recombinant Antibody; scFv Fragment (HPAB-0842-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-0843-FY-S(P) | Human Anti-IL10 Recombinant Antibody; scFv Fragment (HPAB-0843-FY-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3477 | Anti-IL10 Immunohistochemistry Kit | IHC |
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