Recombinant Anti-IL13 Biparatopic Antibody, Tandem scFv (Anrukinzumab x Clone IMA-026) (CAT#: VS-0525-YC216)
This biparatopic antibody (bpAb) binds two distinct IL13 epitopes, having been designed as a tandem scFv. The Anrukinzumab scFv (specific for the IL-13 epitope that binds IL-4Rα) is N-terminally fused to the IMA-026 scFv (specific for the IL-13 epitope that binds IL-13Rα1 and IL-13Rα2).
Specific Inquiry
Subcellular Location
RNA Expression

Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg

Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg

Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg

Figure 4 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13

Figure 4 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Human
- Specificity
- Human IL13
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- Anrukinzumab
- Clone 2
- IMA-026
- Epitope 1
- An epitope that binds IL-4Rα on Interleukin-13 (IL-13).
- Epitope 2
- An epitope that binds IL-13Rα1 and IL-13Rα2 on Interleukin-13 (IL-13).
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Interleukin 13
Target
- Introduction
- Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31 with a length of 1.4kb. IL-13 and IL-4 exhibit a 30% of sequence similarity and have a similar structure.
- Alternative Names
- IL13; interleukin 13; interleukin-13; allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; MGC116786; MGC116788; MGC116789; P600; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13;
- Gene ID
- 3596
- UniProt ID
- P35225
Related Resources
Downloads
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1287z | Mouse Anti-IL13 Recombinant Antibody (clone 39B4) | WB, IP, IF, ELISA | Mouse IgG1, κ |
PABL-232 | Human Anti-IL13 Recombinant Antibody (clone M1295) | WB, IHC, FuncS | Human IgG |
PABL-603 | Human Anti-IL13 Recombinant Antibody (clone C836) | Neut | Chimeric (mouse/human) IgG |
PABL-605 | Human Anti-IL13 Recombinant Antibody (clone H2L6) | ELISA | Humanized IgG |
PABL-606 | Human Anti-IL13 Recombinant Antibody (clone X836) | WB, ELISA, FuncS | Chimeric (mouse/human) IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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