Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-219)
CAT#: AFC-TAB-219
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL13. It is a humanized monoclonal antibody and an experimental immunosuppresive drug for the treatment of asthma that cannot be adequately controlled with inhalable glucocorticoids.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- ELISA, Neut, IF, IP, FC, FuncS
- Conjugate
- Unconjugated
- Trade name
- Tnx-650
- Generic Name
- Lebrikizumab
- Related Disease
- Idiopathic pulmonary fibrosis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Lebrikizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lebrikizumab.
Related Diseases
Asthma
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Lebrikizumab"
DrugMonitor™ Anti-Lebrikizumab Antibody (VS-1224-YC647)Lebrikizumab is a monoclonal antibody binding IL-13 with high affinity and slow off-rate, approved for treating moderate-to-severe atopic dermatitis. The DrugMonitor™ Anti-Lebrikizumab Antibody (VS-1224-YC647) is an anti-drug antibody (ADA) against Lebrikizumab. This drug-based antibody is raised in mice immunized with the Lebrikizumab. The anti-Lebrikizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Lebrikizumab in samples.
See other products for "IL13"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-218 | Anti-Human IL13 Recombinant Antibody (Tralokinumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - lambda |
| TAB-067ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (CNTO 607) | ELISA, Inhib | Human antibody |
| TAB-068ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (01471/G6) | ELISA, Neut | Human antibody |
| TAB-069ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-069ZJ-F(E)) | ELISA, Neut, FC | Human Fab |
| TAB-070ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-070ZJ-F(E)) | ELISA, Neut, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H05 | Anti-Human IL13 Recombinant Antibody (Anrukinzumab) | ELISA, Inhib | IgG1 |
| TAB-219 | Anti-Human IL13 Recombinant Antibody (TAB-219) | ELISA, Neut, IF, IP, FC, FuncS | IgG4 - kappa |
| TAB-043ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (Lc6Hc2) | ELISA | Humanized antibody |
| TAB-044ZJ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-044ZJ-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-045ZJ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-045ZJ-S(P)) | ELISA, Block | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-232 | Human Anti-IL13 Recombinant Antibody (clone M1295) | WB, IHC, FuncS | Human IgG |
| HPAB-AP106-YC | Mouse Anti-IL13 Recombinant Antibody (HPAB-AP106-YC) | WB, ELISA, FC, IHC | Mouse IgG |
| HPAB-AP107-YC | Mouse Anti-IL13 Recombinant Antibody (HPAB-AP107-YC) | ELISA | Mouse IgG |
| HPAB-AP108-YC | Mouse Anti-IL13 Recombinant Antibody (HPAB-AP108-YC) | IHC, Inhib | Mouse IgG |
| HPAB-0286-YJ | Human Anti-IL13 Recombinant Antibody (HPAB-0286-YJ) | ELISA, Antagonist, FuncS | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-598 | Human Anti-IL13 Recombinant Antibody (clone C836); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
| PFBL-600 | Human Anti-IL13 Recombinant Antibody (clone H2L6); Fab Fragment | ELISA | Humanized Fab |
| PFBL-601 | Human Anti-IL13 Recombinant Antibody (clone X836); Fab Fragment | WB, ELISA, FuncS | Chimeric (mouse/human) Fab |
| HPAB-0226CQ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (HPAB-0226CQ-F(E)) | ELISA, Neut, FC, FuncS | Human Fab |
| HPAB-0355-WJ-F(E) | Human Anti-IL13 Recombinant Antibody Fab Fragment (HPAB-0355-WJ-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-598 | Mouse Anti-IL13 Recombinant Antibody (clone C836); scFv Fragment | Neut | Mouse scFv |
| PSBL-600 | Human Anti-IL13 Recombinant Antibody (clone H2L6); scFv Fragment | ELISA | Humanized scFv |
| PSBL-601 | Mouse Anti-IL13 Recombinant Antibody (clone X836); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-0226CQ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0226CQ-S(P)) | ELISA, Neut, FC, FuncS | Human scFv |
| HPAB-0045LY-S(P) | Human Anti-IL13 Recombinant Antibody (clone IMA-026); scfv Fragment | WB | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-022ZJ | Anti-Human IL-13 Recombinant Antibody (C836) | ELISA | |
| TAB-022ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (C836) | ELISA | |
| TAB-023ZJ-S(P) | Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-023ZJ-S(P)) | ELISA, Block | Mouse scFv |
| TAB-022ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (C836) | ELISA | |
| TAB-023ZJ-F(E) | Mouse Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-023ZJ-F(E)) | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-094ZJ | Anti-Human IL-13 Recombinant Antibody (167) | ELISA | Chimeric antibody (mouse/human) |
| TAB-094ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
| TAB-094ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1171CQ | Mouse Anti-IL13 Recombinant Antibody (clone B-B13) | ELISA, ELISPOT, Neut | Mouse IgG1 |
| NEUT-1172CQ | Mouse Anti-IL13 Recombinant Antibody (clone 10X28) | Neut, WB | Mouse IgG1 |
| NEUT-1173CQ | Mouse Anti-IL13 Recombinant Antibody (NEUT-1173CQ) | Neut | Mouse IgG2b |
| NEUT-1174CQ | Mouse Anti-IL13 Recombinant Antibody (clone 32116.11) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1175CQ | Rat Anti-IL13 Recombinant Antibody (clone 5A2) | Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1790 | Rabbit Anti-IL13 Recombinant Antibody (clone DS1790AB) | WB, ICC, FC, IP | Rabbit IgG |
| MOR-4610 | Rabbit Anti-IL13 Recombinant Antibody (clone TH123DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H05 | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H05) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-017ML | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-017ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-218 | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-218) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY129 | CytoStream™ Rat Anti-IL13 Recombinant Antibody (clone JES10-5A2) | ELISA, FC, Neut, IHC, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY124 | Human Anti-IL13 (clone IMA-638) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3484 | Anti-IL13 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC216 | Recombinant Anti-IL13 Biparatopic Antibody, Tandem scFv (Anrukinzumab x Clone IMA-026) | ELISA | Tandem scFv |
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