Recombinant Humanized (from mouse) antibody to Human IL13. Anrukinzumab (IMA-638) is a humanized monoclonal antibody designed for the treatment of asthma.
Figure 1 Visual predictive check for the final model stratified by dose.
Examples included is 200 mg i.v. (study 5, UC patients).
Hua, F., Ribbing, J., Reinisch, W., Cataldi, F., & Martin, S. (2015). A pharmacokinetic comparison of anrukinzumab, an anti‐IL‐13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients. British journal of clinical pharmacology, 80(1), 101-109.
Figure 2 Concentration vs. time profiles of anrukinzumab given as multiple i.v. 200 mg doses to UC patients or non-UC subjects.
Hua, F., Ribbing, J., Reinisch, W., Cataldi, F., & Martin, S. (2015). A pharmacokinetic comparison of anrukinzumab, an anti‐IL‐13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients. British journal of clinical pharmacology, 80(1), 101-109.
Figure 3 Effect of anrukinzumab compared with placebo on fold change in faecal calprotectin.
Reinisch, W., Panés, J., Khurana, S., Toth, G., Hua, F., Comer, G. M., ... & Zhu, H. (2015). Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study. Gut, 64(6), 894-900.
Figure 4 Median total IL-13 level versus time profile by treatment group.
Reinisch, W., Panés, J., Khurana, S., Toth, G., Hua, F., Comer, G. M., ... & Zhu, H. (2015). Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study. Gut, 64(6), 894-900.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-IL13 ADCC Recombinant Antibody (Anrukinzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human IL13. Anrukinzumab (IMA-638) is a humanized monoclonal antibody designed for the treatment of asthma.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1287z | Mouse Anti-IL13 Recombinant Antibody (clone 39B4) | WB, IP, IF, ELISA | Mouse IgG1, κ |
HPAB-0033-WJ | Mouse Anti-IL13 Recombinant Antibody (HPAB-0033-WJ) | ELISA, WB, FC, Inhib | Mouse IgG |
FN-189CQ | Rat Anti-Il13 Recombinant Antibody (clone CBL-1328) | FuncS, Neut, Block | Rat IgG1, κ |
FN-190CQ | Rat Anti-Il13 Recombinant Antibody (clone CBL-1329) | ELISA, FuncS, FC | Rat IgG1, κ |
HPAB-AP106-YC | Mouse Anti-IL13 Recombinant Antibody (HPAB-AP106-YC) | WB, ELISA, FC, IHC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-218 | Anti-Human IL13 Recombinant Antibody (Tralokinumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - lambda |
TAB-068ZJ | Anti-Human IL-13 Recombinant Antibody (01471/G6) | WB, ELISA, Neut | Human antibody |
TAB-069ZJ | Human Anti-IL13 Recombinant Antibody (TAB-069ZJ) | ELISA, Neut, FC | Human IgG |
TAB-070ZJ | Human Anti-IL13 Recombinant Antibody (TAB-070ZJ) | ELISA, Neut, FC | Human IgG |
PABX-115-S (P) | Recombinant Human Anti-IL-13 Antibody scFv Fragment (C836) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-219 | Anti-Human IL13 Recombinant Antibody (Lebrikizumab) | ELISA, Neut, IF, IP, FC, FuncS | IgG4 - kappa |
TAB-043ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (Lc6Hc2) | ELISA | Humanized antibody |
TAB-044ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-044ZJ-F(E)) | ELISA, Neut | Humanized Fab |
TAB-045ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-045ZJ-F(E)) | ELISA, Block | Humanized Fab |
TAB-046ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-046ZJ-F(E)) | ELISA, Block | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-022ZJ | Anti-Human IL-13 Recombinant Antibody (C836) | ELISA | |
TAB-023ZJ | Mouse Anti-IL13 Recombinant Antibody (TAB-023ZJ) | ELISA, Block | Mouse IgG |
TAB-022ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (C836) | ELISA | |
TAB-022ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (C836) | ELISA | |
TAB-023ZJ-F(E) | Mouse Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-023ZJ-F(E)) | ELISA, Block | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-094ZJ | Anti-Human IL-13 Recombinant Antibody (167) | ELISA | Chimeric antibody (mouse/human) |
TAB-094ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
TAB-094ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1171CQ | Mouse Anti-IL13 Recombinant Antibody (clone B-B13) | ELISA, ELISPOT, Neut | Mouse IgG1 |
NEUT-1172CQ | Mouse Anti-IL13 Recombinant Antibody (clone 10X28) | Neut, WB | Mouse IgG1 |
NEUT-1173CQ | Mouse Anti-IL13 Recombinant Antibody (clone 15H10) | Neut | Mouse IgG2b |
NEUT-1174CQ | Mouse Anti-IL13 Recombinant Antibody (clone 32116.11) | ELISA, Neut, WB | Mouse IgG1 |
NEUT-1175CQ | Rat Anti-IL13 Recombinant Antibody (clone 5A2) | Neut | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1790 | Rabbit Anti-IL13 Recombinant Antibody (clone DS1790AB) | WB, ICC, FC, IP | Rabbit IgG |
MOR-4610 | Rabbit Anti-IL13 Recombinant Antibody (clone TH123DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0226CQ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (HPAB-0226CQ-F(E)) | ELISA, Neut, FC, FuncS | Human Fab |
HPAB-0227CQ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (HPAB-0227CQ-F(E)) | ELISA, Neut, FC, FuncS | Human Fab |
HPAB-0228CQ-F(E) | Mouse Anti-IL13 Recombinant Antibody (clone MJ2-7); Fab Fragment | ELISA, FC, Neut | Mouse Fab |
HPAB-0229CQ-F(E) | Human Anti-IL13 Recombinant Antibody (clone huMJ2-7); Fab Fragment | ELISA, FC, Neut | Humanized Fab |
HPAB-0230CQ-F(E) | Mouse Anti-IL13 Recombinant Antibody (clone C65); Fab Fragment | ELISA, FC, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0045LY-S(P) | Human Anti-IL13 Recombinant Antibody (clone IMA-026); scfv Fragment | WB | Humanized scfv |
HPAB-0286-YJ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0286-YJ-S(P)) | ELISA, Antagonist, FuncS | Human scFv |
HPAB-0287-YJ-S(P) | Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0287-YJ-S(P)) | ELISA, Neut, Inhib, FuncS | Mouse scFv |
HPAB-0288-YJ-S(P) | Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0288-YJ-S(P)) | ELISA, Neut, Inhib, FuncS | Mouse scFv |
HPAB-0289-YJ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0289-YJ-S(P)) | ELISA, Neut, Inhib, FuncS | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H05 | Afuco™ Anti-IL13 ADCC Recombinant Antibody (Anrukinzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-017ML | Afuco™ Anti-IL13 ADCC Recombinant Antibody (Dectrekumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
AFC-TAB-219 | Afuco™ Anti-IL13 ADCC Recombinant Antibody (Lebrikizumab), ADCC Enhanced | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
AFC-TAB-218 | Afuco™ Anti-IL13 ADCC Recombinant Antibody (Tralokinumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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