Anti-Human IL13 Recombinant Antibody (Anrukinzumab)

Name: Anti-Human IL13 Recombinant Antibody (Anrukinzumab)
SKU: TAB-H05
Rating: 5 (1 reviews)

CAT#: TAB-H05

Recombinant Humanized (from mouse) antibody to Human IL13. Anrukinzumab (IMA-638) is a humanized monoclonal antibody designed for the treatment of asthma.

Published Data Tested Data Gene Expression

ELISA

Figure 1 Visual predictive check for the final model stratified by dose.

Examples included is 200 mg i.v. (study 5, UC patients).

Hua, F., Ribbing, J., Reinisch, W., Cataldi, F., & Martin, S. (2015). A pharmacokinetic comparison of anrukinzumab, an anti‐IL‐13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients. British journal of clinical pharmacology, 80(1), 101-109.

ELISA

Figure 2 Concentration vs. time profiles of anrukinzumab given as multiple i.v. 200 mg doses to UC patients or non-UC subjects.

Inhib

Figure 3 Effect of anrukinzumab compared with placebo on fold change in faecal calprotectin.

Reinisch, W., Panés, J., Khurana, S., Toth, G., Hua, F., Comer, G. M., ... & Zhu, H. (2015). Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study. Gut, 64(6), 894-900.

Inhib

Figure 4 Median total IL-13 level versus time profile by treatment group.

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ELISA

Figure 1 Anti-Human IL13 Recombinant Antibody (TAB-H05) in ELISA

ELISA analysis of TAB-H05 was performed by coating with Recombinant Human IL13. Then blocked with BSA and incubated with TAB-H05. A HRP-conjugated goat anti-human IgG was used as the secondary antibody (1: 2000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.

Figure 2 Anti-Human IL13 Recombinant Antibody (TAB-H05) in WB

WB analysis of TAB-H05 was performed by loading with Recombinant Human IL13 onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-H05 and a HRP goat anti-human IgG (H+L) was used as the secondary antibody (1: 3000). Chemiluminescent detection was performed.

Figure 3 Anti-Human IL13 Recombinant Antibody (TAB-H05) in DB

DB analysis of TAB-H05 was performed by coating with Recombinant Human IL13.
TAB-H05 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-human IgG (H+L) secondary antibody (1: 3000)
NC: Negative control, PC: Positive control

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg

RNA Expression Figure 4 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13

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Specifications

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1

Specificity
IL13 (interleukin 13, IL-13) [Homo sapiens]

Species Reactivity
Human

Applications
ELISA, Inhib

CAS
910649-32-0

Generic Name
anrukinzumab

UNII
OU46IGC49F

MW
145.4 kDa

Related Disease
Ulcerative colitis (UC)

Product Property

Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.

Applications

Application Notes
The Human IL13 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Inhibition.

Target

Alternative Names
anrukinzumab;910649-32-0;IMA-638;IL13;interleukin 13;interleukin-13;allergic rhinitis;ALRH;BHR1;Bronchial hyperresponsiveness 1 (bronchial asthma);IL 13;MGC116786;MGC116788;MGC116789;P600;Bronchial hyperresponsiveness-1 (bronchial asthma);IL-13;

Gene ID
3596

UniProt ID
P35225

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(Creative Biolabs Cat# TAB-H05, RRID: AB_3112022)

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Biosimilar Overview

Please refer to Anrukinzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Anrukinzumab.

Related Diseases

Asthma

Inflammatory Bowel Diseases

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-H05.pdf

MSDS

MSDS - TAB-H05.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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See other products for "Anrukinzumab"

Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H05)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human IL13. It is a humanized monoclonal antibody designed for the treatment of asthma.

DrugMonitor™ Anti-Anrukinzumab Antibody (VS-1224-YC93)
Anrukinzumab has been used in clinical trials for diagnostic studies in asthma. The DrugMonitor™ Anti-Anrukinzumab Antibody (VS-1224-YC93) is an anti-drug antibody (ADA) against Anrukinzumab. This drug-based antibody is raised in mice immunized with the Anrukinzumab. The anti-Anrukinzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Anrukinzumab in samples.

See other products for "IL13"

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CAT	Product Name	Application	Type
TAB-219	Anti-Human IL13 Recombinant Antibody (TAB-219)	ELISA, Neut, IF, IP, FC, FuncS	IgG4 - kappa
TAB-395CL	Human Anti-IL13 Recombinant Antibody (TAB-395CL)	FuncS	Human IgG
TAB-043ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (Lc6Hc2)	ELISA	Humanized antibody
TAB-044ZJ-S(P)	Human Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-044ZJ-S(P))	ELISA, Neut	Humanized scFv
PABX-115	Recombinant Human Anti-IL-13 Antibody (C836)	WB, ELISA, FuncS	IgG

CAT	Product Name	Application	Type
PABL-603	Human Anti-IL13 Recombinant Antibody (clone C836)	Neut	Chimeric (mouse/human) IgG
PABL-605	Human Anti-IL13 Recombinant Antibody (clone H2L6)	ELISA	Humanized IgG
PABL-606	Human Anti-IL13 Recombinant Antibody (clone X836)	WB, ELISA, FuncS	Chimeric (mouse/human) IgG
PABW-170	Human Anti-IL13 Recombinant Antibody (clone CNTO607)	ELISA, WB, Neut	Human IgG
MOB-0781CT	Recombinant Mouse anti-Human IL13 Monoclonal antibody (43227.22)	ELISA, Neut, WB

CAT	Product Name	Application	Type
PFBL-598	Human Anti-IL13 Recombinant Antibody (clone C836); Fab Fragment	Neut	Chimeric (mouse/human) Fab
PFBL-600	Human Anti-IL13 Recombinant Antibody (clone H2L6); Fab Fragment	ELISA	Humanized Fab
PFBL-601	Human Anti-IL13 Recombinant Antibody (clone X836); Fab Fragment	WB, ELISA, FuncS	Chimeric (mouse/human) Fab
PFBW-170	Human Anti-IL13 Recombinant Antibody (clone CNTO607); Fab Fragment	ELISA, WB, Neut	Human Fab
HPAB-0355-WJ-F(E)	Human Anti-IL13 Recombinant Antibody Fab Fragment (HPAB-0355-WJ-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application	Type
PSBW-170	Human Anti-IL13 Recombinant Antibody (clone CNTO607); scFv Fragment	ELISA, WB, Neut	Human scFv
HPAB-0226CQ-S(P)	Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0226CQ-S(P))	ELISA, Neut, FC, FuncS	Human scFv
HPAB-0227CQ-S(P)	Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0227CQ-S(P))	ELISA, Neut, FC, FuncS	Human scFv
HPAB-0228CQ-S(P)	Mouse Anti-IL13 Recombinant Antibody (clone MJ2-7); scFv Fragment	ELISA, FC, Neut	Mouse scFv
HPAB-0229CQ-S(P)	Human Anti-IL13 Recombinant Antibody (clone huMJ2-7); scFv Fragment	ELISA, FC, Neut	Humanized scFv

CAT	Product Name	Application	Type
TAB-022ZJ	Anti-Human IL-13 Recombinant Antibody (C836)	ELISA
TAB-023ZJ	Mouse Anti-IL13 Recombinant Antibody (TAB-023ZJ)	ELISA, Block	Mouse IgG
TAB-022ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (C836)	ELISA
TAB-023ZJ-S(P)	Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-023ZJ-S(P))	ELISA, Block	Mouse scFv
TAB-022ZJ-F(E)	Anti-Human IL-13 Recombinant Antibody Fab Fragment (C836)	ELISA

CAT	Product Name	Application	Type
TAB-094ZJ	Anti-Human IL-13 Recombinant Antibody (167)	ELISA	Chimeric antibody (mouse/human)
TAB-094ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (167)	ELISA	Chimeric antibody (mouse/human)
TAB-094ZJ-F(E)	Anti-Human IL-13 Recombinant Antibody Fab Fragment (167)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-067ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (CNTO 607)	ELISA, Inhib	Human antibody
TAB-068ZJ-S(P)	Anti-Human IL-13 Recombinant Antibody scFv Fragment (01471/G6)	ELISA, Neut	Human antibody
TAB-069ZJ-S(P)	Human Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-069ZJ-S(P))	ELISA, Neut, FC	Human scFv
TAB-070ZJ-S(P)	Human Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-070ZJ-S(P))	ELISA, Neut, FC	Human scFv
TAB-017ML	Anti-Human IL13 Recombinant Antibody (TAB-017ML)	ELISA, IHC, FC, IP, IF, Inhib	IgG1, κ

CAT	Product Name	Application	Type
NEUT-1171CQ	Mouse Anti-IL13 Recombinant Antibody (clone B-B13)	ELISA, ELISPOT, Neut	Mouse IgG1
NEUT-1172CQ	Mouse Anti-IL13 Recombinant Antibody (clone 10X28)	Neut, WB	Mouse IgG1
NEUT-1173CQ	Mouse Anti-IL13 Recombinant Antibody (NEUT-1173CQ)	Neut	Mouse IgG2b
NEUT-1174CQ	Mouse Anti-IL13 Recombinant Antibody (clone 32116.11)	ELISA, Neut, WB	Mouse IgG1
NEUT-1175CQ	Rat Anti-IL13 Recombinant Antibody (clone 5A2)	Neut	Rat IgG1

CAT	Product Name	Application	Type
MOR-1790	Rabbit Anti-IL13 Recombinant Antibody (clone DS1790AB)	WB, ICC, FC, IP	Rabbit IgG
MOR-4610	Rabbit Anti-IL13 Recombinant Antibody (clone TH123DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
AFC-TAB-H05	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H05)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-017ML	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-017ML)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody
AFC-TAB-219	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-219)	ELISA, Neut, IF, IP, FC, FuncS	ADCC enhanced antibody
AFC-TAB-218	Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-218)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0225-XY129	CytoStream™ Rat Anti-IL13 Recombinant Antibody (clone JES10-5A2)	ELISA, FC, Neut, IHC, WB	Rat IgG1

CAT	Product Name	Application	Type
VS-0425-FY124	Human Anti-IL13 (clone IMA-638) scFv-Fc Chimera	ELISA, FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0525-XY3484	Anti-IL13 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC216	Recombinant Anti-IL13 Biparatopic Antibody, Tandem scFv (Anrukinzumab x Clone IMA-026)	ELISA	Tandem scFv

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