Human Anti-IL13 (clone IMA-638) scFv-Fc Chimera
CAT#: VS-0425-FY124
Anti-IL13 scFv-Fc is a recombinant antibody designed to target and block the activity of Interleukin-13 (IL-13), a key cytokine involved in allergic inflammation, mucus hyperproduction, and fibrosis in diseases like asthma and atopic dermatitis. The scFv portion provides specific binding to IL-13, while the Fc region enhances stability and may contribute to extended half-life. This format aims to neutralize IL-13 signaling, thereby reducing the symptoms and progression of IL-13-driven diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL13
- Species Reactivity
- Human
- Clone
- IMA-638
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Fibrotic and cancerous disorders
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 13
- Gene ID
- 3596
- UniProt ID
- P35225
- Long Name
- Interleukin 13
- Sequence Similarities
- Belongs to the IL-4/IL-13 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn52, Asn63, Asn71, and Asn86
Glycosylation from GlyGen 4 sites
- Protein Refseq
- NP_001341920.1; NP_001341921.1; NP_001341922.1; NP_002179.2
- Function
- Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1.
Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B.
Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils.
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Related Diseases
Asthma
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0226CQ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0226CQ-S(P)) | ELISA, Neut, FC, FuncS | Human scFv |
| HPAB-0227CQ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0227CQ-S(P)) | ELISA, Neut, FC, FuncS | Human scFv |
| HPAB-0228CQ-S(P) | Mouse Anti-IL13 Recombinant Antibody (clone MJ2-7); scFv Fragment | ELISA, FC, Neut | Mouse scFv |
| HPAB-0229CQ-S(P) | Human Anti-IL13 Recombinant Antibody (clone huMJ2-7); scFv Fragment | ELISA, FC, Neut | Humanized scFv |
| HPAB-0230CQ-S(P) | Mouse Anti-IL13 Recombinant Antibody (clone C65); scFv Fragment | ELISA, FC, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
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