Rabbit Anti-INSR Recombinant Antibody (clone 4B2)

Name: Rabbit Anti-INSR Recombinant Antibody (clone 4B2)
SKU: ZG-0028U
Rating: 5 (1 reviews)

CAT#: ZG-0028U

The purified Rabbit Anti-INSR Recombinant Antibody (clone 4B2) displayed high specificity against the INSR protein of human.

Tested Data Gene Expression

Figure 1 Rabbit Anti-INSR Antibody (ZG-0028U) in IF

Immunofluorescence staining of MCF7 Cells with ZG-0028U at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated Goat Anti-Rabbit IgG (H+L).

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human liver

Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg

Normal Tissue Figure 4 Colon

landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg

Normal Tissue Figure 7 Testis

Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg

Normal Tissue Figure 8 Skeletal muscle

Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg

Normal Tissue Figure 9 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR

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Specifications

Immunogen
A synthesized peptide derived from human Insulin Receptor

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human INSR

Species Reactivity
Human

Clone
4B2

Applications
ELISA, IF

Conjugate
Unconjugated

Related Disease
Donohue Syndrome and Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities

Product Property

Purification
Affinity purified

Concentration
See the COA

Buffer
PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Preservative
0.02% sodium azide

Storage
Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Immunofluorescence. Specific conditions should be optimized by the end user.
IF:1:20-1:200

Target

Alternative Names
Insulin receptor; IR; EC 2.7.10.1; CD antigen CD220; Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta; INSR

Gene ID
3643

UniProt ID
P06213

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Related Signaling Pathways

PPAR Signaling Pathway

Related Diseases

Type I Diabetes Mellitus

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - ZG-0028U.pdf

MSDS

MSDS - ZG-0028U.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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