Anti-MMP9 (clone GS-5745) Recombinant Antibody Coupled Liposome (VS-1024-FY113) (CAT#: VS-1024-FY113)

• Potential Clinical Applications
• Glioma

• Clone
• GS-5745

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody specifically designed to bind to human matrix metalloproteinase 9 (MMP9). MMP9 is an important enzyme involved in the degradation of extracellular matrix components, playing a significant role in various physiological processes, including tissue remodeling, wound healing, and inflammation.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• MMP9

• Introduction
• Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

• Alternative Names
• Matrix Metallopeptidase 9; Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase); EC 3.4.24.35; CLG4B; MMP-9; GELB; Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase); Matrix Metalloproteinase-9

• Full Name
• Matrix Metallopeptidase 9

• Gene ID
• 4318

• UniProt ID
• P14780

• Cellular Localization
• Secreted

• Post Translation Modifications
• Processing of the precursor yields different active forms of 64, 67 and 82 kDa.
  Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
  N- and O-glycosylated. (P14780-MMP9_HUMAN)
  Glycosylation at Asn38, Asn120, and Asn127 (NX_P14780 [NX_P14780-1])
  Modification sites at PhosphoSitePlus (P14780)
  Glycosylation from GlyConnect MMP9_HUMAN (6)
  Glycosylation from GlyGen (P14780) 4 sites, 1 N-linked glycan (1 site), 29 O-linked glycans (1 site)

• Protein Refseq
• NP_004985.2

• Function
• Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:2551898, 1480034, 12879005).
  Could play a role in bone osteoclastic resorption (By similarity).
  Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005).
  Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094).
  Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034).
  Degrades fibronectin but not laminin or Pz-peptide.

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