What specific peptide does the 2D2 clone recognize?

The 2D2 clone is a mouse single-chain TCR that specifically recognizes the Mog peptide sequence GWYRSPFSRVVH. This recognition occurs in the context of H2-IAb, making it suitable for autoimmune disease research.

What is the recommended storage temperature?

We recommend storing this product in aliquots at -20 degrees Celsius. To ensure the integrity of the single-chain TCR, you should avoid repeated freezing and thawing of the samples during your experiments.

Mouse Anti-Mog Recombinant Soluble TCR (clone 2D2)

CAT#: scTCR-053YF-S(P)

Recombinant Mouse single-chain TCR (scTCR) 2D2 recognizes Mog peptide (GWYRSPFSRVVH) in the context of H2-IAb. The scTCR is responsible for the specificity of T cells.

Gene Expression

Normal Tissue Figure 1 IHC staining of human cerebral cortex

High expression. RNA expression: 73.8 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21873/ihc_selected.jpg

Normal Tissue Figure 2 IHC staining of human pancreas

Low expression. RNA expression: 0.0 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21873/51773_A_1_3_val_selected.jpg

Normal Tissue Figure 3 Colon

Mucosal lymphoid cells
Staining: Low
Intensity: Moderate
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21873/51773_A_9_3.jpg

Normal Tissue Figure 4 Testis

Leydig cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21873/51773_A_4_6.jpg

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Specifications

Host Species
Mouse

Target
Mog

Species Reactivity
Mouse

Epitope
GWYRSPFSRVVH

MHC
H2-IAb

Clone
2D2

Type
Single-Chain TCR

Related Disease
Autoimmune Disease

Target

Alternative Names
B230317G11Rik

Gene ID
17441

UniProt ID
Q61885

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Breast cancer biomarkers at key points during disease progression

Perfect For Autoimmune Research

This mouse soluble TCR (clone 2D2) is a standard for our autoimmune disease models. It specifically recognizes the Mog peptide GWYRSPFSRVVH in the context of H2-IAb, allowing for precise tracking of specific T cell responses.

Reliable Detection Of MOG

We needed a reagent to detect MOG peptide presentation, and this product delivered. The single-chain format was stable, and it worked well in our assays designed to study the specificity of T cells in mouse models.

Q&As

What specific peptide does the 2D2 clone recognize?

A: The 2D2 clone is a mouse single-chain TCR that specifically recognizes the Mog peptide sequence GWYRSPFSRVVH. This recognition occurs in the context of H2-IAb, making it suitable for autoimmune disease research.
What is the recommended storage temperature?

A: We recommend storing this product in aliquots at -20 degrees Celsius. To ensure the integrity of the single-chain TCR, you should avoid repeated freezing and thawing of the samples during your experiments.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

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Datasheet

Datasheet - scTCR-053YF-S(P).pdf

MSDS

MSDS - scTCR-053YF-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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