Afuco™ Anti-NOTCH2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H67) (CAT#: AFC-TAB-H67)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human NOTCH2. It is a novel anti-cancer stem cell antibody identified by screening against the Notch3 receptor that binds to and prevents signaling through both the Notch2 and Notch3 receptors.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/714_F8_1_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/714_F8_1_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_8_3.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_7_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_7_5.jpg
Figure 5 Testis
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_6_6.jpg
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_6_6.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134250-NOTCH2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134250-NOTCH2
Specifications
- Host Species
- Human
- Derivation
- human
- Type
- ADCC enhanced antibody
- Specificity
- NOTCH2 (notch 2) [Homo sapiens];
- Species Reactivity
- Human
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Generic Name
- Tarextumab
- Related Disease
- Pancreatic cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- NOTCH2; notch 2; Notch (Drosophila) homolog 2, Notch homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Notch homolog 2; hN2; AGS2; HJCYS;
- Gene ID
- 4853
- UniProt ID
- Q04721
Related Resources
Please refer to Tarextumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tarextumab.
Breast Cancer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Tarextumab"
DrugMonitor™ Anti-Tarextumab Antibody (VS-1224-YC1158)Tarextumab is a fully human monoclonal antibody targeting Notch 2/3 receptors, studied in trials for solid tumors, Stage IV pancreatic cancer, and Stage IV small cell lung cancer. The DrugMonitor™ Anti-Tarextumab Antibody (VS-1224-YC1158) is an anti-drug antibody (ADA) against Tarextumab. This drug-based antibody is raised in mice immunized with the Tarextumab. The anti-Tarextumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Tarextumab in samples.
See other products for "NOTCH2"
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IgG Antibody Products
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2555z | Mouse Anti-NOTCH2 Recombinant Antibody (clone 19B5) | ELISA, IHC | Mouse IgG1, κ |
| HPAB-0038-CN | Human Anti-NOTCH2 Recombinant Antibody (HPAB-0038-CN) | FC, ELISA | Human IgG2, κ |
| HPAB-0039-CN | Human Anti-NOTCH2 Recombinant Antibody (HPAB-0039-CN) | FC, ELISA | Human IgG2, κ |
| FAMAB-1387CQ | Mouse Anti-NOTCH2 Recombinant Antibody (clone B9) | Inhib, Block, ELISA, IF | Mouse IgG1 |
| FAMAB-1389CQ | Mouse Anti-NOTCH2 Recombinant Antibody (clone B6) | Inhib, Block, ELISA | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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