Rabbit Anti-NRP1 Recombinant Antibody (VS3-CJ129) (CAT#: VS3-CJ129)

• Immunogen
• Human Neuropilin 1 aa 900 to the C-terminus

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat NRP1

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, ELISA

• Conjugate
• Unconjugated

• Purification
• Protein A affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Buffer
• 40% glycerol, 1% BSA, TBS, pH7.4.

• Preservative
• 0.05% sodium azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD304; NP1; NRP; BDCA4

• Gene ID
• 8829

• UniProt ID
• O14786

• Sequence Similarities
• Belongs to the neuropilin family.

• Cellular Localization
• Cell membrane, Cytoplasm, Mitochondrion

• Protein Refseq
• NP_001019799.1; NP_001019800.1; NP_001316997.1

• Function
• Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880).
  Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273).
  It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273).
  Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
  Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799).
  (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

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