Rabbit Anti-NRP1 Recombinant Antibody (VS3-CJ129)
CAT#: VS3-CJ129
This product is a rabbit antibody that recognizes NRP1.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows moderate granular positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099250-NRP1
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Specifications
- Immunogen
- Human Neuropilin 1 aa 900 to the C-terminus
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NRP1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD304; NP1; NRP; BDCA4
- Gene ID
- 8829
- UniProt ID
- O14786
- Sequence Similarities
- Belongs to the neuropilin family.
- Cellular Localization
- Cell membrane, Cytoplasm, Mitochondrion
- Protein Refseq
- NP_001019799.1; NP_001019800.1; NP_001316997.1
- Function
- Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880).
Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273).
It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273).
Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799).
(Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "NRP1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-264 | Anti-Human NRP1 Recombinant Antibody (Vesencumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-095 | Human Anti-NRP1 Recombinant Antibody; Fab Fragment | Block | Human Fab |
| HPAB-N0370-YC-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-N0370-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0371-YC-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-N0371-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0372-YC-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-N0372-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0373-YC-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-N0373-YC-F(E)) | ELISA, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-095 | Human Anti-NRP1 Recombinant Antibody; scFv Fragment | Block | Human scFv |
| HPAB-0717-FY-F(E) | Mouse Anti-NRP1 Recombinant Antibody (clone AB016); scFv Fragment | FC | Mouse scFv |
| HPAB-0721-FY-F(E) | Mouse Anti-NRP1 Recombinant Antibody (clone AB035); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1357-FY-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-1357-FY-F(E)) | Block, Inhib | Human Fab |
| HPAB-1797-FY-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-1797-FY-F(E)) | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-589MZ | Rabbit Anti-NRP1 Recombinant Antibody (TAB-589MZ) | IHC | Rabbit IgG1 |
| TAB-590MZ | Anti-Human NRP1 Recombinant Antibody (1.004.012) | WB | |
| TAB-589MZ-F(E) | Rabbit Anti-NRP1 Recombinant Antibody; Fab Fragment (TAB-589MZ-F(E)) | IHC | Rabbit Fab |
| TAB-590MZ-F(E) | Anti-Human NRP1 Recombinant Antibody Fab Fragment (1.004.012) | WB, IHC | |
| TAB-591MZ-F(E) | Anti-Human NRP1 Recombinant Antibody Fab Fragment | FC, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1791CQ | Recombinant Rat Anti-Nrp1 Antibody (CBL881) | FC, Neut | IgG2 |
| NEUT-1793CQ | Recombinant Rat Anti-Nrp1 Antibody (CBL384) | CyTOF, FC, Neut | IgG2a |
| NEUT-1794CQ | Recombinant Mouse Anti-Nrp1 Antibody (CBL326) | BL, FC, CyTOF | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2501 | Hi-Affi™ Recombinant Rabbit Anti-NRP1 Monoclonal Antibody (DS2501AB) | WB, IHC-P, IP, FC, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-055CN | Human Anti-NRP1 Recombinant Antibody (NS-055CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-056CN | Human Anti-NRP1 Recombinant Antibody (NS-056CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-057CN | Human Anti-NRP1 Recombinant Antibody (NS-057CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-055CN-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (NS-055CN-F(E)) | ELISA, IP, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0370-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0370-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0371-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0371-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0372-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0372-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-0717-FY | Mouse Anti-NRP1 Recombinant Antibody (clone AB016) | FC | Mouse IgG |
| HPAB-0721-FY | Mouse Anti-NRP1 Recombinant Antibody (clone AB035) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1080-CN | Recombinant Mouse Anti-NRP1 Monoclonal Antibody (A3-D1) | WB, IF, IHC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-264 | Afuco™ Anti-NRP1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-264) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1093 | PE-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1094 | APC-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1095 | FITC-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1096 | A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY206 | AbPlus™ Anti-NRP1 Magnetic Beads (VS-0424-XY206) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY87 | Human Anti-NRP1 (clone Vesencumab) scFv-Fc Chimera | IP, IF, FC, Neut, ELISA, ICC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC189 | Recombinant Anti-NRP1 Vesicular Antibody, EV Displayed (VS-0425-YC189) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4987 | Anti-NRP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4988 | Anti-Rat NRP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4989 | Anti-Human NRP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4990 | Anti-Mouse NRP1 Immunohistochemistry Kit | IHC |
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