Rabbit Anti-NRP1 Recombinant Antibody (VS3-CJ129) (CAT#: VS3-CJ129)
This product is a rabbit antibody that recognizes NRP1.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows moderate granular positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows moderate granular positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/ihc_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_B_9_5.jpg
(Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_B_9_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_7_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_8_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_6_6.jpg
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30278/64887_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099250-NRP1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099250-NRP1
Specifications
- Immunogen
- Human Neuropilin 1 aa 900 to the C-terminus
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NRP1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD304; NP1; NRP; BDCA4
- Gene ID
- 8829
- UniProt ID
- O14786
- Sequence Similarities
- Belongs to the neuropilin family.
- Cellular Localization
- Cell membrane, Cytoplasm, Mitochondrion
- Protein Refseq
- NP_001019799.1; NP_001019800.1; NP_001316997.1
- Function
- Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880).
Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273).
It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273).
Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799).
(Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "NRP1"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-264 | Anti-Human NRP1 Recombinant Antibody (Vesencumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-095 | Human Anti-NRP1 Recombinant Antibody; scFv Fragment | Block | Human scFv |
| HPAB-N0370-YC-S(P) | Human Anti-NRP1 Recombinant Antibody; scFv Fragment (HPAB-N0370-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-0717-FY-F(E) | Mouse Anti-NRP1 Recombinant Antibody (clone AB016); scFv Fragment | FC | Mouse scFv |
| HPAB-0721-FY-F(E) | Mouse Anti-NRP1 Recombinant Antibody (clone AB035); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1797-FY-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-1797-FY-F(E)) | FC, ELISA | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-589MZ-S(P) | Rabbit Anti-NRP1 Recombinant Antibody; scFv Fragment (TAB-589MZ-S(P)) | IHC | Rabbit scFv |
| TAB-590MZ-S(P) | Anti-Human NRP1 Recombinant Antibody scFv Fragment (1.004.012) | WB, IHC | |
| TAB-591MZ-S(P) | Anti-Human NRP1 Recombinant Antibody scFv Fragment | FC, IP | |
| TAB-589MZ-F(E) | Rabbit Anti-NRP1 Recombinant Antibody; Fab Fragment (TAB-589MZ-F(E)) | IHC | Rabbit Fab |
| TAB-590MZ-F(E) | Anti-Human NRP1 Recombinant Antibody Fab Fragment (1.004.012) | WB, IHC |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1791CQ | Recombinant Rat Anti-Nrp1 Antibody (CBL881) | FC, Neut | IgG2 |
| NEUT-1793CQ | Recombinant Rat Anti-Nrp1 Antibody (CBL384) | CyTOF, FC, Neut | IgG2a |
| NEUT-1794CQ | Recombinant Mouse Anti-Nrp1 Antibody (CBL326) | BL, FC, CyTOF | IgG2b |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2483 | Hi-Affi™ Recombinant Rabbit Anti-NRP1 Monoclonal Antibody (DS2483AB) | WB, FC, IP, IHC | IgG |
| HPAB-N0370-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0370-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0371-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0371-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0372-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0372-YC) | ELISA, Inhib | Human IgG4 (S228P) |
| HPAB-N0373-YC | Human Anti-NRP1 Recombinant Antibody (HPAB-N0373-YC) | ELISA, Inhib | Human IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2501 | Hi-Affi™ Recombinant Rabbit Anti-NRP1 Monoclonal Antibody (DS2501AB) | WB, IHC-P, IP, FC, IHC-Fr | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-055CN | Human Anti-NRP1 Recombinant Antibody (NS-055CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-056CN | Human Anti-NRP1 Recombinant Antibody (NS-056CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-057CN | Human Anti-NRP1 Recombinant Antibody (NS-057CN) | ELISA, IP, IF, SPR | Human IgG |
| NS-055CN-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (NS-055CN-F(E)) | ELISA, IP, IF | Human Fab |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-056CN-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (NS-056CN-F(E)) | ELISA, IP, IF | Human Fab |
| NS-057CN-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (NS-057CN-F(E)) | ELISA, IP, IF | Human Fab |
| HPAB-N0370-YC-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-N0370-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0371-YC-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-N0371-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0372-YC-F(E) | Human Anti-NRP1 Recombinant Antibody; Fab Fragment (HPAB-N0372-YC-F(E)) | ELISA, Inhib | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-264 | Afuco™ Anti-NRP1 ADCC Recombinant Antibody (Vesencumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1093 | PE-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1094 | APC-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1095 | FITC-A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC | |
| MHC-CN1096 | A*02:01/Human NRP1 (GMLGMVSGL) MHC Tetramer | FCM, IHC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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