Afuco™ Anti-RTN4 ADCC Recombinant Antibody (Ozanezumab), ADCC Enhanced (CAT#: AFC-TAB-903)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. Ozanezumab is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. Ozanezumab targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/if_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in seminiferous ducts cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in seminiferous ducts cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6_selected.jpg
Figure 3 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_A_6_6_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_A_6_6_selected.jpg
Figure 4 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_B_8_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_B_8_5.jpg
Figure 5 Cerebellum
(Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_B_7_8.jpg
(Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_B_7_8.jpg
Figure 6 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_9_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_9_3.jpg
Figure 7 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6.jpg
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6.jpg
Figure 8 RNA cell line category: Cell line enhanced (HHSteC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115310-RTN4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115310-RTN4
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Ozanezumab
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Generic Name
- Ozanezumab
- Related Disease
- Multiple sclerosis (MS)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ozanezumab; 1310680-64-8; RTN4; reticulon 4; reticulon-4; ASY; KIAA0886; NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC;
- Gene ID
- 57142
- UniProt ID
- Q9NQC3
Related Resources
Please refer to Ozanezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ozanezumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ozanezumab"
Anti-Human Nogo-A Recombinant Antibody (Ozanezumab)Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. Ozanezumab is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. Ozanezumab targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.
See other products for "RTN4"
Select a product category from the dropdown menu below to view related products.
Please select product type
Recombinant Antibody
Human Antibody
Mouse Antibody
Chimeric Antibody
Humanized Antibody
Rabbit Monoclonal Antibody
Fab Fragment Antibody
scFv Fragment Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2437z | Mouse Anti-RTN4 Recombinant Antibody (clone 28B12) | WB, ELISA, IF, IP | Mouse IgM, κ |
| MOB-2424CT | Recombinant Mouse anti-Human RTN4 Monoclonal antibody (9XH27) | WB, IHC-P, IHC-Fr | |
| MOB-186CQ | Mouse Anti-RTN4 Antibody | ELISA, WB | Mouse IgG1 |
| HPAB-0047-WJ | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2) | ELISA, WB, Inhib, IHC, IF | Mouse IgG |
| MRO-1101-CN | Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (JM02-34) | WB, IF, IHC, IP, FC | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AFC-TAB-903. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: Block, Cyt, FuncS, Inhib
Application: FC, FuncS, IHC, ELISA
-1.png)
Application: IB, ELISA, FC, FuncS
Application: WB, ELISA, FuncS, IB, FC, SPR, Apop
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, WB
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
