Anti-TNFRSF17 Antibody Prodrug, Protease Activated (VS-1025-YC112)
CAT#: VS-1025-YC112
The Anti-TNFRSF17 Antibody Prodrug, Protease Activated (VS-1025-YC112) is an antibody prodrug comprised of a recombinant mouse antibody targeting human TNFRSF17, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to TNFRSF17 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to TNFRSF17 effectively. TNFRSF17, also known as BCMA (B-cell Maturation Antigen), is a receptor highly and selectively expressed on malignant plasma cells in multiple myeloma. Its role in myeloma cell survival and proliferation makes it a premier, highly selective target for new immunotherapies, including the highly effective BCMA-targeted CAR T-cell therapies.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000048462-TNFRSF17
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human TNFRSF17
- Target
- TNFRSF17
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
- Alternative Names
- TNFRSF17; BCM; BCMA; CD269; TNFRSF13A
- Gene ID
- 608
- UniProt ID
- Q02223
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| PABL-019 | Mouse Anti-TNFRSF17 Recombinant Antibody (clone J22.9-xi) | ELISA, FC, Neut, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
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| PSBL-019 | Mouse Anti-TNFRSF17 Recombinant Antibody (clone J22.9-xi); scFv Fragment | Neut, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
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| PFBL-019 | Mouse Anti-TNFRSF17 Recombinant Antibody (clone J22.9-xi); Fab Fragment | Neut, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
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| TAB-0137CL | Mouse Anti-TNFRSF17 Recombinant Antibody (TAB-0137CL) | FC, Block, IB, Cyt, IF | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1207CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1207CL) | ELISA, FC, FuncS | Chimeric (rat/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1208CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1208CL) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
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| TAB-1209CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1209CL) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1210CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1210CL) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1211CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1211CL) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1212CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1212CL) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1218CL | Mouse Anti-TNFRSF17 Recombinant Antibody (TAB-1218CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1219CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1219CL) | ELISA, FC, Block, Cyt, FuncS | Chimeric (Mouse/Human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1220CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1220CL) | ELISA, Cyt, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1221CL | Anti-Human TNFRSF17 Recombinant Antibody (TBL-CLN1) | Cyt |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1222CL | Mouse Anti-TNFRSF17 Recombinant Antibody (TAB-1222CL) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1226CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1226CL) | FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1227CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1227CL) | FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1228CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1228CL) | FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1229CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1229CL) | FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1230CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1230CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1231CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1231CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1232CL | Human Anti-TNFRSF17 Recombinant Antibody (TAB-1232CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1220CL-S(P) | Human Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (TAB-1220CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0250CT | Recombinant Mouse anti-Human TNFRSF17 Monoclonal antibody (EML209) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2125CQ | Rat Anti-TNFRSF17 Recombinant Antibody (clone 3D44) | Neut, WB | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2126CQ | Rat Anti-TNFRSF17 Recombinant Antibody (clone Vicky-1) | WB, Neut, ELISA, FC, ICC, IF, IHC | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2127CQ | Rat Anti-TNFRSF17 Recombinant Antibody (clone CBL370) | WB, Block | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2128CQ | Rat Anti-Tnfrsf17 Recombinant Antibody (clone 17B1) | Neut, WB | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2129CQ | Rat Anti-Tnfrsf17 Recombinant Antibody (clone CBL336) | Block, WB | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2130CQ | Mouse Anti-Tnfrsf17 Recombinant Antibody (clone CBL337) | Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2131CQ | Rat Anti-Tnfrsf17 Recombinant Antibody (clone Vicky-2) | WB, Neut, FC, IP | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2132CQ | Rat Anti-Tnfrsf17 Recombinant Antibody (clone CBL183) | Neut, WB | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0009-DJB | Mouse Anti-TNFRSF17 Recombinant Antibody (HPAB-0009-DJB) | ELISA, Neut, FC, SPR, ADCC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0010-DJB | Human Anti-TNFRSF17 Recombinant Antibody (HPAB-0010-DJB) | ELISA, Neut, ADCC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0009-DJB-S(P) | Mouse Anti-TNFRSF17 Recombinant Antibody scFv Fragment (HPAB-0009-DJB-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0010-DJB-S(P) | Human Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (HPAB-0010-DJB-S(P)) | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0011-DJB-S(P) | Mouse Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (HPAB-0011-DJB-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0012-DJB-S(P) | Mouse Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (HPAB-0012-DJB-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0009-DJB-F(E) | Mouse Anti-TNFRSF17 Recombinant Antibody Fab Fragment (HPAB-0009-DJB-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0010-DJB-F(E) | Human Anti-TNFRSF17 Recombinant Antibody; Fab Fragment (HPAB-0010-DJB-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0011-DJB-F(E) | Mouse Anti-TNFRSF17 Recombinant Antibody; Fab Fragment (HPAB-0011-DJB-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0012-DJB-F(E) | Human Anti-TNFRSF17 Recombinant Antibody; Fab Fragment (HPAB-0012-DJB-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY2 | Human Anti-TNFRSF17 scFv-Fc Chimera (VS-0325-FY2) | FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC680 | Recombinant Anti-TNFRSF17 Vesicular Antibody, EV Displayed (VS-0425-YC680) | ELISA, FC, SPR, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7376 | Anti-TNFRSF17 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC337 | SmartAb™ Recombinant Anti-TNFRSF17 pH-dependent Antibody (VS-0825-YC337) | Inhibition | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY264 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1225-XY264) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY265 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1225-XY265) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY266 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1225-XY266) | IHC, ICC, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY267 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1225-XY267) | WB | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY268 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1225-XY268) | WB, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY1001 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1125-XY1001) | WB, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY1002 | Rat Anti-TNFRSF17 Recombinant Antibody (VS-1125-XY1002) | ICC, IF, FC | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY1003 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1125-XY1003) | IHC, ICC, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY1004 | Rabbit Anti-TNFRSF17 Recombinant Antibody (VS-1125-XY1004) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY1005 | Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1125-XY1005) | IHC, ELISA | Mouse IgG2, kappa |
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