Human Anti-TNFRSF17 scFv-Fc Chimera (VS-0325-FY2) (CAT#: VS-0325-FY2)
The anti-BCMA scFv-Fc antibody binds to human BCMA with an affinity of approximately 6.44 nM. When tested against NCI-H929 cells, it exhibits an EC₅₀ value of 17.68 nM. This antibody is utilized in various therapeutic and diagnostic applications targeting multiple myeloma and other BCMA-expressing malignancies. Its high specificity and affinity make it a valuable tool in research and potential therapeutic development for related diseases.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000048462-TNFRSF17
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000048462-TNFRSF17
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TNFRSF17
- Species Reactivity
- Human
- Applications
- Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- TNF Receptor Superfamily Member 17; B-Cell Maturation Protein; BCMA; BCM; Tumor Necrosis Factor Receptor Superfamily, Member 17; Tumor Necrosis Factor Receptor Superfamily Member 17
- Gene ID
- 608
- UniProt ID
- Q02223
- Long Name
- TNF Receptor Superfamily Member 17
- Cellular Localization
- Cell membrane; Endomembrane system
- Post Translation Modifications
- Glycosylation at Asn42
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect TNR17_HUMAN (2978)
Glycosylation from GlyGen 1 site
- Protein Refseq
- NP_001183.2
- Function
- Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.
Promotes B-cell survival and plays a role in the regulation of humoral immunity.
Activates NF-kappa-B and JNK.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1620z | Mouse Anti-TNFRSF17 Recombinant Antibody (clone 2A10) | WB, ELISA, FC | Mouse IgG1 |
| ZG-0263U | Mouse Anti-TNFRSF17 Recombinant Antibody (clone 4D7E5) | ELISA, WB, IHC | Mouse IgG2b |
| ZG-0264U | Mouse Anti-TNFRSF17 Recombinant Antibody (clone 10A9F7) | ELISA, WB, IF, FC | Mouse IgG2b |
| VS3-WK6 | Rabbit Anti-TNFRSF17 Recombinant Antibody (clone DM2) | ELISA, FC, IP, IF | Rabbit IgG |
| VS3-WK11 | Rabbit Anti-TNFRSF17 Recombinant Antibody (clone DM3) | ELISA, FC, IP, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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