Mouse Anti-TNFRSF17 Recombinant Antibody (VS-1125-XY1005)

CAT#: VS-1125-XY1005

Intended for use in cell therapy, this TNFRSF17 recombinant antibody helps enhance the efficiency of cell therapy applications. It also plays a key role in companion diagnostics to fulfill clinical detection needs.​

Gene Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)

Specifications

  • Host Animal
  • Mouse
  • Applications
  • IHC, ELISA
  • Specificity
  • TNFRSF17
  • Target
  • TNFRSF17
  • Species Reactivity
  • Human
  • Type
  • Mouse IgG2, kappa
  • Purity
  • >95%, determined by SDS-PAGE
  • Purification
  • Protein A purified
  • Format
  • Liquid
  • Buffer
  • PBS with 0.05% BSA
  • Preservative
  • 0.05% sodium azide
  • Storage
  • Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.

Target

  • Introduction
  • Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), or B cell maturation antigen (BCMA), is a transmembrane receptor expressed primarily on mature B cells and plasma cells. It binds B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), regulating plasma cell survival and differentiation. BCMA is highly overexpressed on malignant plasma cells in multiple myeloma (MM) with minimal normal tissue expression. It is a top target for MM therapies, including CAR-T cells (idecabtagene vicleucel, ciltacabtagene autoleucel), ADCs (belantamab mafodotin), and bispecific antibodies. BCMA targeting has transformed MM treatment, achieving deep responses in refractory cases.
  • Alternative Names
  • BCM, BCMA, CD269, TNFRSF13A
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Downloadable Resources

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Datasheet

MSDS

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Recommended Dilution Buffer

Secondary Antibody

Isotype Control

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