AbPlus™ Anti-TNFSF11 Magnetic Beads (VS-0724-YC1276)
CAT#: VS-0724-YC1276
The AbPlus Anti-TNFSF11 Magnetic Beads (VS-0724-YC1276) is an innovative affinity resin which is bound with anti-TNFSF11 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of TNFSF11 protein under native and denaturing conditions.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_B_7_5_val_selected.jpg
Normal Tissue
Figure 3 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9193/ihc_selected.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HSkMC, NTERA-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120659-TNFSF11
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-TNFSF11 specific antibody
- Target
- TNFSF11
- Immunogen
- Recombinant human RANKL/OPGL/TNFSF11/CD254, aa 63-244.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
- Alternative Names
- TNF Superfamily Member 11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF-Related Activation-Induced Cytokine; Osteoclast Differentiation Factor; Osteoprotegerin Ligand; TRANCE; RANKL; OPGL; ODF; Receptor Activator Of Nuclear Factor Kappa B Ligand; Receptor Activator Of Nuclear Factor Kappa-B Ligand;
- Gene ID
- 8600
- UniProt ID
- O14788
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MOR-3619 | Rabbit Anti-TNFSF11 Recombinant Antibody (clone DS3619AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0171-YC | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0171-YC) | ELISA, Neut | Human IgG2, κ |
| HPAB-0172-YC | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0172-YC) | ELISA | Human IgG |
| HPAB-0173-YC | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0173-YC) | ELISA | Human IgG |
| HPAB-0574-FY | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0574-FY) | ELISA | Humanized IgG2 |
| HPAB-0575-FY | Mouse Anti-TNFSF11 Recombinant Antibody (HPAB-0575-FY) | ELISA | Mouse IgG |
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|---|---|---|---|
| HPAB-0685-CN-S(P) | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0685-CN-S(P)); scFv Fragment | Neut | Human scFv |
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| HPAB-N0284-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-N0284-YC-S(P)) | ELISA, Neut, Inhib | Human scFv |
| HPAB-N0285-YC-S(P) | Mouse Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-N0285-YC-S(P)) | Neut, FuncS | Mouse scFv |
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| HPAB-AP834-YC-F(E) | Mouse Anti-TNFSF11 Recombinant Antibody (clone 4D3); Fab Fragment | Inhib, FuncS | Mouse Fab |
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