Human Anti-TNFSF11 scFv-Fc Chimera (VS-0425-FY171)
CAT#: VS-0425-FY171
Anti-TNFSF11 scFv-Fc is a recombinant fusion protein designed to target and neutralize TNFSF11, also known as receptor activator of nuclear factor kappa-B ligand (RANKL). TNFSF11 plays a crucial role in osteoclast differentiation and activation, making it a key player in bone metabolism and diseases such as osteoporosis and rheumatoid arthritis.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_B_7_5_val_selected.jpg
Normal Tissue
Figure 3 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9193/ihc_selected.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HSkMC, NTERA-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120659-TNFSF11
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Specifications
- Immunogen
- The immunogen is human TNFSF11/CD254.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human TNFSF11
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- TNF Superfamily Member 11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF-Related Activation-Induced Cytokine; Osteoclast Differentiation Factor; Osteoprotegerin Ligand; TRANCE; RANKL; OPGL; ODF; Receptor Activator Of Nuclear Factor Kappa B Ligand; Receptor Activator Of Nuclear Factor Kappa-B Ligand
- Gene ID
- 8600
- UniProt ID
- O14788
- Long Name
- TNF Superfamily Member 11
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cell membrane, Cytoplasm
- Post Translation Modifications
- The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
The cleavage may be catalyzed by ADAM17.
Glycosylation at Asn171 and Asn198
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- XP_011533582.1; XP_016876291.1; XP_016876292.1; XP_047286663.1; XP_054231050.1
- Function
- Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK.
Osteoclast differentiation and activation factor.
Augments the ability of dendritic cells to stimulate naive T-cell proliferation.
May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response.
May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-299CT | Anti-Human RANKL Recombinant Antibody (RL1) | ELISA | Human antibody |
| TAB-300CT | Anti-Human RANKL Recombinant Antibody (RL2) | ELISA | Human antibody |
| TAB-301CT | Anti-Human RANKL Recombinant Antibody (RL3) | ELISA | Human antibody |
| TAB-302CT | Anti-Human RANKL Recombinant Antibody (RL4) | ELISA | Human antibody |
| TAB-303CT | Anti-Human RANKL Recombinant Antibody (RL5) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-310CT | Anti-Human RANKL Recombinant Antibody | ELISA, FC, Neut | |
| TAB-310CT-S(P) | Anti-Human RANKL Recombinant Antibody scFv Fragment | ELISA, FC, Neut | |
| TAB-310CT-F(E) | Anti-Human RANKL Recombinant Antibody Fab Fragment | ELISA, FC, Neut |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1773CT | Recombinant Mouse anti-Mouse TNFSF11 Monoclonal antibody (23B779) | IHC-FoFr, WB | |
| HPAB-0334-YJ | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-1) | ELISA, FC, Block, FuncS | Human IgG4, κ |
| HPAB-0335-YJ | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-2) | ELISA, FC, Block, FuncS | Human IgG4, κ |
| HPAB-0404-YJ | Rabbit Anti-TNFSF11 Recombinant Antibody (HPAB-0404-YJ) | ELISA, FC, Neut, Inhib, FuncS | Rabbit IgG2, κ |
| HPAB-0405-YJ | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0405-YJ) | ELISA, FC, Neut, Inhib, FuncS | Humanized IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2178CQ | Rat Anti-Tnfsf11 Recombinant Antibody (clone IK22/5) | Block, FC, IP, WB | Rat IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2179CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL188) | IHC, Neut, WB | Mouse IgG2 |
| NEUT-2180CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL488) | IHC, Neut | Mouse IgG2b |
| NEUT-2181CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL578) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3619 | Rabbit Anti-TNFSF11 Recombinant Antibody (clone DS3619AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0171-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-0171-YC-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0172-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-0172-YC-S(P)) | ELISA | Human scFv |
| HPAB-0173-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-0173-YC-S(P)) | ELISA | Human scFv |
| HPAB-0334-YJ-S(P) | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-1); scFv Fragment | ELISA, FC, Block, Inhib, FuncS | Human scFv |
| HPAB-0335-YJ-S(P) | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-2); scFv Fragment | ELISA, FC, Block, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0171-YC-F(E) | Human Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-0171-YC-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0404-YJ-F(E) | Rabbit Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-0404-YJ-F(E)) | ELISA, FC, Neut, Inhib, FuncS | Rabbit Fab |
| HPAB-0405-YJ-F(E) | Human Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-0405-YJ-F(E)) | ELISA, FC, Neut, Inhib, FuncS | Humanized Fab |
| HPAB-0406-YJ-F(E) | Rabbit Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-0406-YJ-F(E)) | ELISA, FC, Neut, Inhib, FuncS | Rabbit Fab |
| HPAB-0407-YJ-F(E) | Human Anti-TNFSF11 Recombinant Antibody; Fab Fragment (HPAB-0407-YJ-F(E)) | ELISA, FC, Neut, Inhib, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H18 | Afuco™ Anti-TNFSF11 Recombinant Antibody (AFC-TAB-H18), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0313-YC | Human Anti-TNFSF11 Recombinant Single Domain Antibody (HPAB-J0313-YC) | ELISA, Block | Human VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY258 | AbPlus™ Anti-TNFSF11 Magnetic Beads (VS-0424-XY258) | IP, Protein Purification | |
| VS-0724-YC1276 | AbPlus™ Anti-TNFSF11 Magnetic Beads (VS-0724-YC1276) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC646 | Recombinant Anti-TNFSF11 Vesicular Antibody, EV Displayed (VS-0425-YC646) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7388 | Anti-TNFSF11 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7389 | Anti-Mouse TNFSF11 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7390 | Anti-Human TNFSF11 Immunohistochemistry Kit | IHC |
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