Human Anti-TNFSF11 scFv-Fc Chimera (VS-0425-FY171) (CAT#: VS-0425-FY171)

• Immunogen
• The immunogen is human TNFSF11/CD254.

• Host Species
• Human

• Type
• Human IgG2, scFv-Fc

• Specificity
• Human TNFSF11

• Species Reactivity
• Human

• Applications
• ELISA

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• TNF Superfamily Member 11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF-Related Activation-Induced Cytokine; Osteoclast Differentiation Factor; Osteoprotegerin Ligand; TRANCE; RANKL; OPGL; ODF; Receptor Activator Of Nuclear Factor Kappa B Ligand; Receptor Activator Of Nuclear Factor Kappa-B Ligand

• Gene ID
• 8600

• UniProt ID
• O14788

• Long Name
• TNF Superfamily Member 11

• Sequence Similarities
• Belongs to the tumor necrosis factor family.

• Cellular Localization
• Cell membrane, Cytoplasm

• Post Translation Modifications
• The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
  The cleavage may be catalyzed by ADAM17.
  Glycosylation at Asn171 and Asn198
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 2 sites

• Protein Refseq
• XP_011533582.1; XP_016876291.1; XP_016876292.1; XP_047286663.1; XP_054231050.1

• Function
• Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK.
  Osteoclast differentiation and activation factor.
  Augments the ability of dendritic cells to stimulate naive T-cell proliferation.
  May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response.
  May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

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