Anti-Human RANKL Recombinant Antibody Fab Fragment

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Citations

1. Zhao, Wenbin, et al. "Synovial fibroblasts regulate the cytotoxicity and osteoclastogenic activity of synovial natural killer cells through the RANKL-RANK axis in osteoarthritis." Scandinavian Journal of Immunology 94.2 (2021): e13069. https://doi.org/10.1111/sji.13069
   This study investigates the role of the RANKL-RANK axis in modulating natural killer (NK) cell function in osteoarthritis (OA). Using a rat collagenase-induced OA model, the researchers found that compared to splenic NK cells, synovial NK cells showed reduced cytotoxicity and lower production of IFN-γ, perforin, and granzyme B when stimulated with IL-12, IL-15, and IL-18. The study reveals that synovial NK cells highly express RANK (receptor activator of nuclear factor-κB), while OA synovial fibroblasts (SFs) upregulate RANKL (RANK ligand) expression. Through co-culture experiments, the researchers demonstrated that OA SFs inhibit NK cell cytotoxicity but promote their osteoclastogenic activity through the RANKL-RANK signaling pathway.
   Creative Biolabs provided a RANKL neutralizing antibody (CAT# TAB-310CT-F(E)) that was crucial for demonstrating the involvement of RANKL in NK cell-mediated osteoclast formation. When this antibody was added to the NK cell-bone marrow cell co-cultures, it significantly suppressed osteoclast generation, confirming that RANKL plays a central role in the osteoclastogenic effect of NK cells. This finding helped establish a novel mechanism by which synovial fibroblasts modulate NK cell reactivity in OA, potentially opening new avenues for therapeutic interventions targeting the RANKL-RANK axis to address bone loss in osteoarthritis.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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