Recombinant Anti-TNFSF11 Vesicular Antibody, EV Displayed (VS-0425-YC646)
CAT#: VS-0425-YC646
The Recombinant Anti-TNFSF11 Vesicular Antibody, EV Displayed (VS-0425-YC646) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TNFSF11-expressed cells or tissues. TNFSF11 is a TNF cytokine family member regulating osteoclast differentiation, crucial for T-cell dependent immune response and bone homeostasis.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_B_7_5_val_selected.jpg
Normal Tissue
Figure 3 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9193/ihc_selected.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45142/114242_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HSkMC, NTERA-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120659-TNFSF11
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TNFSF11
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TNF superfamily member 11
- Biological Process
- Differentiation
- Molecular Function
- Cytokine, Developmental protein, Receptor
- Introduction
- This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
- Alternative Names
- CD254, ODF, OPGL, RANKL, TRANCE
- Gene ID
- 8600
- UniProt ID
- O14788
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| NEUT-2179CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL188) | IHC, Neut, WB | Mouse IgG2 |
| NEUT-2180CQ | Mouse Anti-TNFSF11 Recombinant Antibody (clone CBL488) | IHC, Neut | Mouse IgG2b |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3619 | Rabbit Anti-TNFSF11 Recombinant Antibody (clone DS3619AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0685-CN | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0685-CN) | Neut | Human IgG |
| HPAB-0686-CN | Human Anti-TNFSF11 Recombinant Antibody (HPAB-0686-CN) | Neut | Human IgG |
| HPAB-0334-YJ | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-1) | ELISA, FC, Block, FuncS | Human IgG4, κ |
| HPAB-0335-YJ | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-2) | ELISA, FC, Block, FuncS | Human IgG4, κ |
| VS7-0425-WR1023 | Mouse Anti-TNFSF11 Recombinant Antibody (clone 8A7B9) | WB, IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0727LY-S(P) | Mouse Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-0727LY-S(P)) | IHC, ICC, FC, WB, ELISA | Mouse scfv |
| HPAB-N0283-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody (clone Omut-10); scFv Fragment | ELISA | Human scFv |
| HPAB-N0284-YC-S(P) | Human Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-N0284-YC-S(P)) | ELISA, Neut, Inhib | Human scFv |
| HPAB-N0285-YC-S(P) | Mouse Anti-TNFSF11 Recombinant Antibody; scFv Fragment (HPAB-N0285-YC-S(P)) | Neut, FuncS | Mouse scFv |
| HPAB-1186WJ-S(P) | Mouse Anti-TNFSF11 Recombinant Antibody (clone 14F3); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H18 | Afuco™ Anti-TNFSF11 Recombinant Antibody (AFC-TAB-H18), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0334-YJ-F(E) | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-1); Fab Fragment | ELISA, FC, Block, Inhib, FuncS | Human Fab |
| HPAB-0335-YJ-F(E) | Human Anti-TNFSF11 Recombinant Antibody (clone BA05-2); Fab Fragment | ELISA, FC, Block, Inhib, FuncS | Human Fab |
| HPAB-AP830-YC-F(E) | Mouse Anti-TNFSF11 Recombinant Antibody (clone FLG5); Fab Fragment | Inhib, FuncS | Mouse Fab |
| HPAB-AP831-YC-F(E) | Mouse Anti-TNFSF11 Recombinant Antibody (clone 3F1); Fab Fragment | Inhib, FuncS | Mouse Fab |
| HPAB-AP832-YC-F(E) | Mouse Anti-TNFSF11 Recombinant Antibody (clone 4A5); Fab Fragment | Inhib, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0313-YC | Human Anti-TNFSF11 Recombinant Single Domain Antibody (HPAB-J0313-YC) | ELISA, Block | Human VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY258 | AbPlus™ Anti-TNFSF11 Magnetic Beads (VS-0424-XY258) | IP, Protein Purification | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY171 | Human Anti-TNFSF11 scFv-Fc Chimera (VS-0425-FY171) | ELISA | Human IgG2, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7388 | Anti-TNFSF11 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7389 | Anti-Mouse TNFSF11 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7390 | Anti-Human TNFSF11 Immunohistochemistry Kit | IHC |
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