Mouse Anti-WAS Recombinant Antibody (clone 7B10E4)
CAT#: VS7-0425-WR1122
This product is a mouse IgG2a antibody that binds to human WAS. The antibody 7B10E4 recognizes specific amino acid domain of human WAS (AA: 57-170). It can be used for IHC and FC assays.






Specifications
- Immunogen
- Recombinant human WAS (AA: 57-170) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human WAS
- Species Reactivity
- Human
- Clone
- 7B10E4
- Molecule Class
- Wiskott-Aldrich Syndrome (WAS) Family
- Applications
- IHC, FC
- Conjugate
- Unconjugated
- Related Disease
- Wiskott-Aldrich syndrome (WAS); Thrombocytopenia 1 (THC1); Neutropenia, severe congenital, X-linked (XLN)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry-Paraffin: 1:200 - 1:1000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- WAS; Thrombocytopenia 1 (X-Linked); THC1; WASP; Wiskott-Aldrich Syndrome (Eczema-Thrombocytopenia); Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein; IMD2; THC; Eczema-Thrombocytopenia; SCNX
- Gene ID
- 7454
- UniProt ID
- P42768
- Long Name
- Wiskott-Aldrich Syndrome
- Cellular Localization
- Cytoplasm; Cytoskeleton; Nucleus
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- NP_000368.1
- Function
- Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905).; Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410).; Possible regulator of lymphocyte and platelet function (PubMed:9405671).; Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809).; In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068).; Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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