Anti-Notch3 (clone ch28)-mc-MMAE ADC
CAT#: ADC-010CL
This ADC product is composed of an anti-Notch3 antibody (clone ch28) conjugated via mc linker to MMAE (ch28-mc-MMAE). It has demonstrated a response in Notch3 expressing cancer treatment.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong nuclear and moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AF22, MCF7, RT4, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074181-NOTCH3
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Specifications
- Antibody Overview
- Rat-Human Chimeric Anti-Notch3 Antibody, , ch28
- Clone
- ch28
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- 2-Methylalanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
Target
- Introduction
- This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
- Alternative Names
- NOTCH3; notch 3; IMF2; CASIL; CADASIL; neurogenic locus notch homolog protein 3; Notch homolog 3;
- Gene ID
- 4854
- UniProt ID
- Q9UM47
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Related Diseases
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Datasheet
MSDS
COA
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See other products for "Clone ch28"
- CAT
- Product Name
See other products for "NOTCH3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1929z | Mouse Anti-NOTCH3 Recombinant Antibody (clone 22H2) | WB, ELISA | Mouse IgG2a |
| HPAB-0282-YC | Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23) | ELISA, IHC, WB | Mouse IgG |
| HPAB-0283-YC | Mouse Anti-NOTCH3 Recombinant Antibody (HPAB-0283-YC) | ELISA, IHC, WB | Mouse IgG |
| HPAB-0284-YC | Mouse Anti-NOTCH3 Recombinant Antibody (HPAB-0284-YC) | ELISA, IHC, WB | Mouse IgG |
| HPAB-0754-WJ | Human Anti-NOTCH3 Recombinant Antibody (clone N37) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-556MZ | Mouse Anti-NOTCH3 Recombinant Antibody (TAB-556MZ) | ELISA, Inhib, WB, Neut | Mouse IgG1, κ |
| TAB-562MZ | Anti-Human NOTCH3 Recombinant Antibody (TAB-562MZ) | ELISA, FuncS | |
| TAB-563MZ | Anti-Human NOTCH3 Recombinant Antibody (TAB-563MZ) | ELISA, FuncS | |
| TAB-556MZ-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-556MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-562MZ-S(P) | Anti-Human NOTCH3 Recombinant Antibody scFv Fragment (TAB-562MZ-S(P)) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-557MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-557MZ) | Inhib, Neut | Chimeric (mouse/human) IgG1 |
| TAB-557MZ-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-557MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-557MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-557MZ-F(E)) | ELISA, WB | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-558MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-558MZ) | Inhib, Neut | Humanized IgG1 |
| TAB-558MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-558MZ-S(P)) | ELISA, WB | Humanized scFv |
| TAB-558MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-558MZ-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-554MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-554MZ-S(P)) | ELISA | Human scFv |
| TAB-555MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-555MZ-S(P)) | ELISA | Human scFv |
| TAB-560MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-560MZ-S(P)) | FC | Human scFv |
| TAB-561MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-561MZ-S(P)) | FC | Human scFv |
| TAB-554MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-554MZ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0577-YC-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (HPAB-M0577-YC-S(P)) | FC, WB, Inhib | Human scFv |
| HPAB-1010WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N3WCR3P1B12); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-1011WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone hN3S2_160); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-1012WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N3LHCS_18); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-1013WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N1wc561); scFv Fragment | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0577-YC-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-M0577-YC-F(E)) | FC, WB, Inhib | Human Fab |
| HPAB-1010WJ-F(E) | Human Anti-NOTCH3 Recombinant Antibody (clone N3WCR3P1B12); Fab Fragment | ELISA, WB, FC | Human Fab |
| HPAB-1011WJ-F(E) | Human Anti-NOTCH3 Recombinant Antibody (clone hN3S2_160); Fab Fragment | ELISA, WB, FC | Human Fab |
| HPAB-1012WJ-F(E) | Human Anti-NOTCH3 Recombinant Antibody (clone N3LHCS_18); Fab Fragment | ELISA, WB, FC | Human Fab |
| HPAB-1013WJ-F(E) | Human Anti-NOTCH3 Recombinant Antibody (clone N1wc561); Fab Fragment | ELISA, WB, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC81 | Rabbit Anti-NOTCH3 Antibody (VS-0924-YC81) - Cancer Stem Cell Marker | IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY161 | Human Anti-NOTCH3 scFv-Fc Chimera (VS-0425-FY161) | ELISA, FC, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC122 | Recombinant Anti-NOTCH3 Vesicular Antibody, EV Displayed (VS-0425-YC122) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4910 | Anti-NOTCH3 Immunohistochemistry Kit | IHC |
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